6WS1
Crystal structure of human phenylethanolamine N-methyltransferase (PNMT) in complex with (2S)-2-amino-4-((((2R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(3-(7,8-dichloro-1,2,3,4-tetrahydroisoquinolin-4-yl)propyl)amino)butanoic acid and AdoHcy (SAH)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004603 | molecular_function | phenylethanolamine N-methyltransferase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0032259 | biological_process | methylation |
| A | 0042418 | biological_process | epinephrine biosynthetic process |
| A | 0042423 | biological_process | catecholamine biosynthetic process |
| B | 0004603 | molecular_function | phenylethanolamine N-methyltransferase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0008168 | molecular_function | methyltransferase activity |
| B | 0032259 | biological_process | methylation |
| B | 0042418 | biological_process | epinephrine biosynthetic process |
| B | 0042423 | biological_process | catecholamine biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | binding site for residue SAH A 301 |
| Chain | Residue |
| A | TYR27 |
| A | PHE102 |
| A | ASN106 |
| A | ASP158 |
| A | VAL159 |
| A | ALA181 |
| A | PHE182 |
| A | VAL187 |
| A | TYR35 |
| A | TYR40 |
| A | GLY79 |
| A | SER80 |
| A | GLY81 |
| A | THR83 |
| A | TYR85 |
| A | ASP101 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 302 |
| Chain | Residue |
| A | ILE133 |
| A | EDO303 |
| site_id | AC3 |
| Number of Residues | 1 |
| Details | binding site for residue EDO A 303 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | binding site for residue CD A 304 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | binding site for residue K A 305 |
| site_id | AC6 |
| Number of Residues | 20 |
| Details | binding site for residue U87 B 301 |
| Chain | Residue |
| B | TYR27 |
| B | TYR35 |
| B | TYR40 |
| B | GLY79 |
| B | SER80 |
| B | GLY81 |
| B | THR83 |
| B | TYR85 |
| B | ASP101 |
| B | PHE102 |
| B | LEU103 |
| B | ASN106 |
| B | ILE157 |
| B | ASP158 |
| B | VAL159 |
| B | HIS160 |
| B | ALA181 |
| B | PHE182 |
| B | VAL187 |
| B | GLU219 |
| site_id | AC7 |
| Number of Residues | 1 |
| Details | binding site for residue EDO B 302 |
Functional Information from PROSITE/UniProt
| site_id | PS01100 |
| Number of Residues | 17 |
| Details | NNMT_PNMT_TEMT NNMT/PNMT/TEMT family of methyltransferases signature. LIDIGSGPTVYQLLSAC |
| Chain | Residue | Details |
| A | LEU75-CYS91 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| B | ASN106 | |
| B | ALA181 | |
| A | ALA181 | |
| B | TYR35 | |
| B | TYR40 | |
| B | TYR85 | |
| B | ASP101 | |
| A | TYR35 | |
| A | TYR40 | |
| A | TYR85 | |
| A | ASP101 | |
| A | ASN106 | |
| Chain | Residue | Details |
| B | GLY79 | |
| B | ASP158 | |
| A | ASP158 | |
| A | GLY79 | |
| Chain | Residue | Details |
| B | GLU219 | |
| B | ASP267 | |
| A | ASP267 | |
| A | GLU219 | |
| Chain | Residue | Details |
| B | SER7 | |
| A | SER7 | |
