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6WRH

The crystal structure of Papain-Like Protease of SARS CoV-2 , C111S mutant

Functional Information from GO Data
ChainGOidnamespacecontents
A0006508biological_processproteolysis
A0008234molecular_functioncysteine-type peptidase activity
Functional Information from PDB Data
site_idAC1
Number of Residues4
Detailsbinding site for residue ZN A 501
ChainResidue
ACYS189
ACYS192
ACYS224
ACYS226

site_idAC2
Number of Residues10
Detailsbinding site for residue PO4 A 502
ChainResidue
AGLY271
AHIS272
AHOH692
AHOH751
AHOH884
ATRP106
AASN109
AASN110
ASER111
ALYS228

site_idAC3
Number of Residues4
Detailsbinding site for residue PO4 A 503
ChainResidue
AGLU1
AHIS47
ASER49
AHOH616

site_idAC4
Number of Residues7
Detailsbinding site for residue PO4 A 504
ChainResidue
AHIS73
AASN128
APRO129
AGLN174
AHIS175
AGLU203
AHOH637

site_idAC5
Number of Residues3
Detailsbinding site for residue CL A 505
ChainResidue
APHE127
AHOH708
AHOH901

site_idAC6
Number of Residues5
Detailsbinding site for residue CL A 506
ChainResidue
ATHR10
AVAL11
AASP12
AASN15
AGLU67

site_idAC7
Number of Residues5
Detailsbinding site for residue GOL A 507
ChainResidue
ASER85
AASN88
AHIS89
AHOH636
AHOH790

site_idAC8
Number of Residues7
Detailsbinding site for residue GOL A 508
ChainResidue
AARG65
AASP164
ATYR264
ATYR273
ATHR301
AHOH611
AHOH642

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues37
DetailsZN_FING: C4-type => ECO:0000255|PROSITE-ProRule:PRU00444
ChainResidueDetails
ACYS189-CYS226

site_idSWS_FT_FI2
Number of Residues1
DetailsACT_SITE: For PL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00444, ECO:0000269|PubMed:32726803
ChainResidueDetails
ASER111

site_idSWS_FT_FI3
Number of Residues2
DetailsACT_SITE: For PL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00444
ChainResidueDetails
AHIS272
AASP286

site_idSWS_FT_FI4
Number of Residues4
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00444
ChainResidueDetails
ACYS189
ACYS192
ACYS224
ACYS226

226707

PDB entries from 2024-10-30

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