6WR4
Structure of human ATG9A, the only transmembrane protein of the core autophagy machinery
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000045 | biological_process | autophagosome assembly |
| A | 0000139 | cellular_component | Golgi membrane |
| A | 0000407 | cellular_component | phagophore assembly site |
| A | 0000421 | cellular_component | autophagosome membrane |
| A | 0005515 | molecular_function | protein binding |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005768 | cellular_component | endosome |
| A | 0005770 | cellular_component | late endosome |
| A | 0005776 | cellular_component | autophagosome |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0005794 | cellular_component | Golgi apparatus |
| A | 0005802 | cellular_component | trans-Golgi network |
| A | 0006869 | biological_process | lipid transport |
| A | 0006914 | biological_process | autophagy |
| A | 0016020 | cellular_component | membrane |
| A | 0017121 | biological_process | plasma membrane phospholipid scrambling |
| A | 0017128 | molecular_function | phospholipid scramblase activity |
| A | 0031902 | cellular_component | late endosome membrane |
| A | 0031966 | cellular_component | mitochondrial membrane |
| A | 0034045 | cellular_component | phagophore assembly site membrane |
| A | 0034497 | biological_process | protein localization to phagophore assembly site |
| A | 0034727 | biological_process | piecemeal microautophagy of the nucleus |
| A | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| A | 0055037 | cellular_component | recycling endosome |
| A | 0055038 | cellular_component | recycling endosome membrane |
| A | 0060349 | biological_process | bone morphogenesis |
| A | 0061709 | biological_process | reticulophagy |
| A | 0097300 | biological_process | programmed necrotic cell death |
| B | 0000045 | biological_process | autophagosome assembly |
| B | 0000139 | cellular_component | Golgi membrane |
| B | 0000407 | cellular_component | phagophore assembly site |
| B | 0000421 | cellular_component | autophagosome membrane |
| B | 0005515 | molecular_function | protein binding |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005768 | cellular_component | endosome |
| B | 0005770 | cellular_component | late endosome |
| B | 0005776 | cellular_component | autophagosome |
| B | 0005783 | cellular_component | endoplasmic reticulum |
| B | 0005789 | cellular_component | endoplasmic reticulum membrane |
| B | 0005794 | cellular_component | Golgi apparatus |
| B | 0005802 | cellular_component | trans-Golgi network |
| B | 0006869 | biological_process | lipid transport |
| B | 0006914 | biological_process | autophagy |
| B | 0016020 | cellular_component | membrane |
| B | 0017121 | biological_process | plasma membrane phospholipid scrambling |
| B | 0017128 | molecular_function | phospholipid scramblase activity |
| B | 0031902 | cellular_component | late endosome membrane |
| B | 0031966 | cellular_component | mitochondrial membrane |
| B | 0034045 | cellular_component | phagophore assembly site membrane |
| B | 0034497 | biological_process | protein localization to phagophore assembly site |
| B | 0034727 | biological_process | piecemeal microautophagy of the nucleus |
| B | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| B | 0055037 | cellular_component | recycling endosome |
| B | 0055038 | cellular_component | recycling endosome membrane |
| B | 0060349 | biological_process | bone morphogenesis |
| B | 0061709 | biological_process | reticulophagy |
| B | 0097300 | biological_process | programmed necrotic cell death |
| C | 0000045 | biological_process | autophagosome assembly |
| C | 0000139 | cellular_component | Golgi membrane |
| C | 0000407 | cellular_component | phagophore assembly site |
| C | 0000421 | cellular_component | autophagosome membrane |
| C | 0005515 | molecular_function | protein binding |
| C | 0005739 | cellular_component | mitochondrion |
| C | 0005768 | cellular_component | endosome |
| C | 0005770 | cellular_component | late endosome |
| C | 0005776 | cellular_component | autophagosome |
| C | 0005783 | cellular_component | endoplasmic reticulum |
| C | 0005789 | cellular_component | endoplasmic reticulum membrane |
| C | 0005794 | cellular_component | Golgi apparatus |
| C | 0005802 | cellular_component | trans-Golgi network |
| C | 0006869 | biological_process | lipid transport |
| C | 0006914 | biological_process | autophagy |
| C | 0016020 | cellular_component | membrane |
| C | 0017121 | biological_process | plasma membrane phospholipid scrambling |
| C | 0017128 | molecular_function | phospholipid scramblase activity |
| C | 0031902 | cellular_component | late endosome membrane |
| C | 0031966 | cellular_component | mitochondrial membrane |
| C | 0034045 | cellular_component | phagophore assembly site membrane |
| C | 0034497 | biological_process | protein localization to phagophore assembly site |
| C | 0034727 | biological_process | piecemeal microautophagy of the nucleus |
| C | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| C | 0055037 | cellular_component | recycling endosome |
| C | 0055038 | cellular_component | recycling endosome membrane |
| C | 0060349 | biological_process | bone morphogenesis |
| C | 0061709 | biological_process | reticulophagy |
| C | 0097300 | biological_process | programmed necrotic cell death |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | binding site for residue LMN A 901 |
| Chain | Residue |
| A | ARG245 |
| A | GLY246 |
| A | TYR249 |
| A | GLU252 |
| A | TRP257 |
| A | ASN297 |
| A | TRP307 |
| A | TYR311 |
| A | LMN902 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue LMN A 902 |
| Chain | Residue |
| A | PHE142 |
| A | TYR249 |
| A | LEU253 |
| A | TRP257 |
| A | GLU266 |
| A | LEU300 |
| A | LMN901 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | binding site for residue LMN B 901 |
| Chain | Residue |
| B | ARG245 |
| B | GLY246 |
| B | TYR249 |
| B | GLU252 |
| B | TRP257 |
| B | ASN297 |
| B | TRP307 |
| B | TYR311 |
| B | LMN902 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue LMN B 902 |
| Chain | Residue |
| B | PHE142 |
| B | TYR249 |
| B | LEU253 |
| B | TRP257 |
| B | GLU266 |
| B | LEU300 |
| B | LMN901 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | binding site for residue LMN C 901 |
| Chain | Residue |
| C | ARG245 |
| C | GLY246 |
| C | TYR249 |
| C | GLU252 |
| C | TRP257 |
| C | ASN297 |
| C | TRP307 |
| C | TYR311 |
| C | LMN902 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue LMN C 902 |
| Chain | Residue |
| C | PHE142 |
| C | TYR249 |
| C | LEU253 |
| C | TRP257 |
| C | GLU266 |
| C | LEU300 |
| C | LMN901 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1938 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305 |
| Chain | Residue | Details |
| A | ALA2-CYS61 | |
| B | PRO302-VAL319 | |
| B | ALA329-PRO371 | |
| B | ILE425-GLN470 | |
| B | LEU481-PRO483 | |
| B | CYS493-VAL839 | |
| C | ALA2-CYS61 | |
| C | CYS155-ILE290 | |
| C | PRO302-VAL319 | |
| C | ALA329-PRO371 | |
| C | ILE425-GLN470 | |
| A | CYS155-ILE290 | |
| C | LEU481-PRO483 | |
| C | CYS493-VAL839 | |
| A | PRO302-VAL319 | |
| A | ALA329-PRO371 | |
| A | ILE425-GLN470 | |
| A | LEU481-PRO483 | |
| A | CYS493-VAL839 | |
| B | ALA2-CYS61 | |
| B | CYS155-ILE290 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 267 |
| Details | TRANSMEM: Helical => ECO:0000269|PubMed:32610138, ECO:0000269|PubMed:33106659, ECO:0007744|PDB:6WQZ, ECO:0007744|PDB:6WR4, ECO:0007744|PDB:7JLO, ECO:0007744|PDB:7JLP, ECO:0007744|PDB:7JLQ |
| Chain | Residue | Details |
| A | MET62-VAL84 | |
| C | ASN129-ILE154 | |
| C | LEU372-TYR397 | |
| C | VAL407-PHE424 | |
| A | ASN129-ILE154 | |
| A | LEU372-TYR397 | |
| A | VAL407-PHE424 | |
| B | MET62-VAL84 | |
| B | ASN129-ILE154 | |
| B | LEU372-TYR397 | |
| B | VAL407-PHE424 | |
| C | MET62-VAL84 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 153 |
| Details | TOPO_DOM: Lumenal => ECO:0000305 |
| Chain | Residue | Details |
| A | SER85-GLU128 | |
| A | ASP398-HIS406 | |
| B | SER85-GLU128 | |
| B | ASP398-HIS406 | |
| C | SER85-GLU128 | |
| C | ASP398-HIS406 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 30 |
| Details | INTRAMEM: INTRAMEM => ECO:0000269|PubMed:32610138, ECO:0000269|PubMed:33106659, ECO:0007744|PDB:6WQZ, ECO:0007744|PDB:6WR4, ECO:0007744|PDB:7JLP, ECO:0007744|PDB:7JLQ |
| Chain | Residue | Details |
| A | LEU291-CYS301 | |
| B | LEU291-CYS301 | |
| C | LEU291-CYS301 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 24 |
| Details | INTRAMEM: INTRAMEM => ECO:0000269|PubMed:32610138, ECO:0000269|PubMed:33106659, ECO:0007744|PDB:6WQZ, ECO:0007744|PDB:6WR4, ECO:0007744|PDB:7JLO, ECO:0007744|PDB:7JLP, ECO:0007744|PDB:7JLQ |
| Chain | Residue | Details |
| A | LEU320-GLY328 | |
| B | LEU320-GLY328 | |
| C | LEU320-GLY328 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 27 |
| Details | INTRAMEM: INTRAMEM => ECO:0000269|PubMed:32610138, ECO:0007744|PDB:6WQZ |
| Chain | Residue | Details |
| A | TYR471-LEU480 | |
| B | TYR471-LEU480 | |
| C | TYR471-LEU480 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 24 |
| Details | INTRAMEM: INTRAMEM => ECO:0000269|PubMed:32610138, ECO:0000269|PubMed:33106659, ECO:0007744|PDB:6WQZ, ECO:0007744|PDB:7JLP |
| Chain | Residue | Details |
| A | ILE484-PHE492 | |
| B | ILE484-PHE492 | |
| C | ILE484-PHE492 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 3 |
| Details | MOD_RES: N-acetylalanine => ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378 |
| Chain | Residue | Details |
| A | ALA2 | |
| B | ALA2 | |
| C | ALA2 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 3 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER14 | |
| B | SER14 | |
| C | SER14 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 3 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q68FE2 |
| Chain | Residue | Details |
| A | SER16 | |
| B | SER16 | |
| C | SER16 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 6 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER18 | |
| A | SER656 | |
| B | SER18 | |
| B | SER656 | |
| C | SER18 | |
| C | SER656 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 3 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER735 | |
| B | SER735 | |
| C | SER735 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 6 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692 |
| Chain | Residue | Details |
| A | SER738 | |
| A | SER741 | |
| B | SER738 | |
| B | SER741 | |
| C | SER738 | |
| C | SER741 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 3 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER828 | |
| B | SER828 | |
| C | SER828 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16940348, ECO:0000269|PubMed:27316455 |
| Chain | Residue | Details |
| A | ASN99 | |
| B | ASN99 | |
| C | ASN99 |
