6WR4

Structure of human ATG9A, the only transmembrane protein of the core autophagy machinery

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000045	biological_process	autophagosome assembly
A	0000139	cellular_component	Golgi membrane
A	0000407	cellular_component	phagophore assembly site
A	0000421	cellular_component	autophagosome membrane
A	0000423	biological_process	mitophagy
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005768	cellular_component	endosome
A	0005770	cellular_component	late endosome
A	0005776	cellular_component	autophagosome
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005794	cellular_component	Golgi apparatus
A	0005802	cellular_component	trans-Golgi network
A	0006869	biological_process	lipid transport
A	0006914	biological_process	autophagy
A	0016020	cellular_component	membrane
A	0017121	biological_process	plasma membrane phospholipid scrambling
A	0017128	molecular_function	phospholipid scramblase activity
A	0031410	cellular_component	cytoplasmic vesicle
A	0031902	cellular_component	late endosome membrane
A	0031966	cellular_component	mitochondrial membrane
A	0034045	cellular_component	phagophore assembly site membrane
A	0034497	biological_process	protein localization to phagophore assembly site
A	0034727	biological_process	piecemeal microautophagy of the nucleus
A	0055037	cellular_component	recycling endosome
A	0055038	cellular_component	recycling endosome membrane
A	0060349	biological_process	bone morphogenesis
A	0061709	biological_process	reticulophagy
A	0097060	cellular_component	synaptic membrane
A	0097300	biological_process	programmed necrotic cell death
B	0000045	biological_process	autophagosome assembly
B	0000139	cellular_component	Golgi membrane
B	0000407	cellular_component	phagophore assembly site
B	0000421	cellular_component	autophagosome membrane
B	0000423	biological_process	mitophagy
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005768	cellular_component	endosome
B	0005770	cellular_component	late endosome
B	0005776	cellular_component	autophagosome
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0005794	cellular_component	Golgi apparatus
B	0005802	cellular_component	trans-Golgi network
B	0006869	biological_process	lipid transport
B	0006914	biological_process	autophagy
B	0016020	cellular_component	membrane
B	0017121	biological_process	plasma membrane phospholipid scrambling
B	0017128	molecular_function	phospholipid scramblase activity
B	0031410	cellular_component	cytoplasmic vesicle
B	0031902	cellular_component	late endosome membrane
B	0031966	cellular_component	mitochondrial membrane
B	0034045	cellular_component	phagophore assembly site membrane
B	0034497	biological_process	protein localization to phagophore assembly site
B	0034727	biological_process	piecemeal microautophagy of the nucleus
B	0055037	cellular_component	recycling endosome
B	0055038	cellular_component	recycling endosome membrane
B	0060349	biological_process	bone morphogenesis
B	0061709	biological_process	reticulophagy
B	0097060	cellular_component	synaptic membrane
B	0097300	biological_process	programmed necrotic cell death
C	0000045	biological_process	autophagosome assembly
C	0000139	cellular_component	Golgi membrane
C	0000407	cellular_component	phagophore assembly site
C	0000421	cellular_component	autophagosome membrane
C	0000423	biological_process	mitophagy
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005768	cellular_component	endosome
C	0005770	cellular_component	late endosome
C	0005776	cellular_component	autophagosome
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0005794	cellular_component	Golgi apparatus
C	0005802	cellular_component	trans-Golgi network
C	0006869	biological_process	lipid transport
C	0006914	biological_process	autophagy
C	0016020	cellular_component	membrane
C	0017121	biological_process	plasma membrane phospholipid scrambling
C	0017128	molecular_function	phospholipid scramblase activity
C	0031410	cellular_component	cytoplasmic vesicle
C	0031902	cellular_component	late endosome membrane
C	0031966	cellular_component	mitochondrial membrane
C	0034045	cellular_component	phagophore assembly site membrane
C	0034497	biological_process	protein localization to phagophore assembly site
C	0034727	biological_process	piecemeal microautophagy of the nucleus
C	0055037	cellular_component	recycling endosome
C	0055038	cellular_component	recycling endosome membrane
C	0060349	biological_process	bone morphogenesis
C	0061709	biological_process	reticulophagy
C	0097060	cellular_component	synaptic membrane
C	0097300	biological_process	programmed necrotic cell death

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	binding site for residue LMN A 901

Chain	Residue
A	ARG245
A	GLY246
A	TYR249
A	GLU252
A	TRP257
A	ASN297
A	TRP307
A	TYR311
A	LMN902

---

site_id	AC2
Number of Residues	7
Details	binding site for residue LMN A 902

Chain	Residue
A	PHE142
A	TYR249
A	LEU253
A	TRP257
A	GLU266
A	LEU300
A	LMN901

---

site_id	AC3
Number of Residues	9
Details	binding site for residue LMN B 901

Chain	Residue
B	ARG245
B	GLY246
B	TYR249
B	GLU252
B	TRP257
B	ASN297
B	TRP307
B	TYR311
B	LMN902

---

site_id	AC4
Number of Residues	7
Details	binding site for residue LMN B 902

Chain	Residue
B	PHE142
B	TYR249
B	LEU253
B	TRP257
B	GLU266
B	LEU300
B	LMN901

---

site_id	AC5
Number of Residues	9
Details	binding site for residue LMN C 901

Chain	Residue
C	ARG245
C	GLY246
C	TYR249
C	GLU252
C	TRP257
C	ASN297
C	TRP307
C	TYR311
C	LMN902

---

site_id	AC6
Number of Residues	7
Details	binding site for residue LMN C 902

Chain	Residue
C	PHE142
C	TYR249
C	LEU253
C	TRP257
C	GLU266
C	LEU300
C	LMN901

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	267
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"32610138","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33106659","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WQZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WR4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7JLO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7JLP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7JLQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	30
Details	Intramembrane: {"evidences":[{"source":"PubMed","id":"32610138","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33106659","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WQZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WR4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7JLP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7JLQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	318
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	24
Details	Intramembrane: {"evidences":[{"source":"PubMed","id":"32610138","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33106659","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WQZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WR4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7JLO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7JLP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7JLQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	24
Details	Topological domain: {"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	27
Details	Intramembrane: {"evidences":[{"source":"PubMed","id":"32610138","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WQZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	24
Details	Intramembrane: {"evidences":[{"source":"PubMed","id":"32610138","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33106659","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WQZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7JLP","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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