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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6WQZ

Structure of human ATG9A, the only transmembrane protein of the core autophagy machinery

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006914	biological_process	autophagy
B	0006914	biological_process	autophagy
C	0006914	biological_process	autophagy
D	0006914	biological_process	autophagy
E	0006914	biological_process	autophagy
F	0006914	biological_process	autophagy

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	binding site for residue LMN C 801

Chain	Residue
C	ILE135
C	ARG245
C	TYR249
C	ASN297
C	LEU300
C	ILE304
C	TRP307
C	TYR311
C	LMN802

site_id	AC2
Number of Residues	4
Details	binding site for residue LMN C 802

Chain	Residue
C	LEU45
C	TYR249
C	TRP257
C	LMN801

site_id	AC3
Number of Residues	9
Details	binding site for residue LMN B 801

Chain	Residue
B	ILE135
B	ARG245
B	TYR249
B	ASN297
B	LEU300
B	ILE304
B	TRP307
B	TYR311
B	LMN802

site_id	AC4
Number of Residues	4
Details	binding site for residue LMN B 802

Chain	Residue
B	LEU45
B	TYR249
B	TRP257
B	LMN801

site_id	AC5
Number of Residues	9
Details	binding site for residue LMN A 801

Chain	Residue
A	ILE135
A	ARG245
A	TYR249
A	ASN297
A	LEU300
A	ILE304
A	TRP307
A	TYR311
A	LMN802

site_id	AC6
Number of Residues	4
Details	binding site for residue LMN A 802

Chain	Residue
A	LEU45
A	TYR249
A	TRP257
A	LMN801

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1800
Details	TOPO_DOM: Cytoplasmic => ECO:0000305

Chain	Residue	Details
C	ALA2-CYS61
F	ALA329-PRO371
F	ILE425-GLN470
F	LEU481-PRO483
B	ALA2-CYS61
B	CYS155-ILE290
B	PRO302-VAL319
B	ALA329-PRO371
B	ILE425-GLN470
B	LEU481-PRO483
A	ALA2-CYS61
C	CYS155-ILE290
A	CYS155-ILE290
A	PRO302-VAL319
A	ALA329-PRO371
A	ILE425-GLN470
A	LEU481-PRO483
E	ALA2-CYS61
E	CYS155-ILE290
E	PRO302-VAL319
E	ALA329-PRO371
E	ILE425-GLN470
C	PRO302-VAL319
E	LEU481-PRO483
D	ALA2-CYS61
D	CYS155-ILE290
D	PRO302-VAL319
D	ALA329-PRO371
D	ILE425-GLN470
D	LEU481-PRO483
C	ALA329-PRO371
C	ILE425-GLN470
C	LEU481-PRO483
F	ALA2-CYS61
F	CYS155-ILE290
F	PRO302-VAL319

site_id	SWS_FT_FI2
Number of Residues	534
Details	TRANSMEM: Helical => ECO:0000269\|PubMed:32610138, ECO:0000269\|PubMed:33106659, ECO:0007744\|PDB:6WQZ, ECO:0007744\|PDB:6WR4, ECO:0007744\|PDB:7JLO, ECO:0007744\|PDB:7JLP, ECO:0007744\|PDB:7JLQ

Chain	Residue	Details
C	MET62-VAL84
B	ASN129-ILE154
B	LEU372-TYR397
B	VAL407-PHE424
A	MET62-VAL84
A	ASN129-ILE154
A	LEU372-TYR397
A	VAL407-PHE424
E	MET62-VAL84
E	ASN129-ILE154
E	LEU372-TYR397
C	ASN129-ILE154
E	VAL407-PHE424
D	MET62-VAL84
D	ASN129-ILE154
D	LEU372-TYR397
D	VAL407-PHE424
C	LEU372-TYR397
C	VAL407-PHE424
F	MET62-VAL84
F	ASN129-ILE154
F	LEU372-TYR397
F	VAL407-PHE424
B	MET62-VAL84

site_id	SWS_FT_FI3
Number of Residues	306
Details	TOPO_DOM: Lumenal => ECO:0000305

Chain	Residue	Details
C	SER85-GLU128
E	ASP398-HIS406
D	SER85-GLU128
D	ASP398-HIS406
C	ASP398-HIS406
F	SER85-GLU128
F	ASP398-HIS406
B	SER85-GLU128
B	ASP398-HIS406
A	SER85-GLU128
A	ASP398-HIS406
E	SER85-GLU128

site_id	SWS_FT_FI4
Number of Residues	60
Details	INTRAMEM: INTRAMEM => ECO:0000269\|PubMed:32610138, ECO:0000269\|PubMed:33106659, ECO:0007744\|PDB:6WQZ, ECO:0007744\|PDB:6WR4, ECO:0007744\|PDB:7JLP, ECO:0007744\|PDB:7JLQ

Chain	Residue	Details
C	LEU291-CYS301
F	LEU291-CYS301
B	LEU291-CYS301
A	LEU291-CYS301
E	LEU291-CYS301
D	LEU291-CYS301

site_id	SWS_FT_FI5
Number of Residues	48
Details	INTRAMEM: INTRAMEM => ECO:0000269\|PubMed:32610138, ECO:0000269\|PubMed:33106659, ECO:0007744\|PDB:6WQZ, ECO:0007744\|PDB:6WR4, ECO:0007744\|PDB:7JLO, ECO:0007744\|PDB:7JLP, ECO:0007744\|PDB:7JLQ

Chain	Residue	Details
C	LEU320-GLY328
F	LEU320-GLY328
B	LEU320-GLY328
A	LEU320-GLY328
E	LEU320-GLY328
D	LEU320-GLY328

site_id	SWS_FT_FI6
Number of Residues	54
Details	INTRAMEM: INTRAMEM => ECO:0000269\|PubMed:32610138, ECO:0007744\|PDB:6WQZ

Chain	Residue	Details
C	TYR471-LEU480
F	TYR471-LEU480
B	TYR471-LEU480
A	TYR471-LEU480
E	TYR471-LEU480
D	TYR471-LEU480

site_id	SWS_FT_FI7
Number of Residues	48
Details	INTRAMEM: INTRAMEM => ECO:0000269\|PubMed:32610138, ECO:0000269\|PubMed:33106659, ECO:0007744\|PDB:6WQZ, ECO:0007744\|PDB:7JLP

Chain	Residue	Details
C	ILE484-PHE492
F	ILE484-PHE492
B	ILE484-PHE492
A	ILE484-PHE492
E	ILE484-PHE492
D	ILE484-PHE492

site_id	SWS_FT_FI8
Number of Residues	6
Details	MOD_RES: N-acetylalanine => ECO:0007744\|PubMed:22223895, ECO:0007744\|PubMed:22814378

Chain	Residue	Details
C	ALA2
F	ALA2
B	ALA2
A	ALA2
E	ALA2
D	ALA2

site_id	SWS_FT_FI9
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
C	SER14
F	SER14
B	SER14
A	SER14
E	SER14
D	SER14

site_id	SWS_FT_FI10
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:Q68FE2

Chain	Residue	Details
C	SER16
F	SER16
B	SER16
A	SER16
E	SER16
D	SER16

site_id	SWS_FT_FI11
Number of Residues	12
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:18669648, ECO:0007744\|PubMed:23186163

Chain	Residue	Details
C	SER18
E	SER656
D	SER18
D	SER656
C	SER656
F	SER18
F	SER656
B	SER18
B	SER656
A	SER18
A	SER656
E	SER18

site_id	SWS_FT_FI12
Number of Residues	6
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:16940348, ECO:0000269\|PubMed:27316455

Chain	Residue	Details
C	ASN99
F	ASN99
B	ASN99
A	ASN99
E	ASN99
D	ASN99

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PDB entries from 2024-07-17

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