6WQZ

Structure of human ATG9A, the only transmembrane protein of the core autophagy machinery

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006914	biological_process	autophagy
B	0006914	biological_process	autophagy
C	0006914	biological_process	autophagy
D	0006914	biological_process	autophagy
E	0006914	biological_process	autophagy
F	0006914	biological_process	autophagy

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	binding site for residue LMN C 801

Chain	Residue
C	ILE135
C	ARG245
C	TYR249
C	ASN297
C	LEU300
C	ILE304
C	TRP307
C	TYR311
C	LMN802

---

site_id	AC2
Number of Residues	4
Details	binding site for residue LMN C 802

Chain	Residue
C	LEU45
C	TYR249
C	TRP257
C	LMN801

---

site_id	AC3
Number of Residues	9
Details	binding site for residue LMN B 801

Chain	Residue
B	ILE135
B	ARG245
B	TYR249
B	ASN297
B	LEU300
B	ILE304
B	TRP307
B	TYR311
B	LMN802

---

site_id	AC4
Number of Residues	4
Details	binding site for residue LMN B 802

Chain	Residue
B	LEU45
B	TYR249
B	TRP257
B	LMN801

---

site_id	AC5
Number of Residues	9
Details	binding site for residue LMN A 801

Chain	Residue
A	ILE135
A	ARG245
A	TYR249
A	ASN297
A	LEU300
A	ILE304
A	TRP307
A	TYR311
A	LMN802

---

site_id	AC6
Number of Residues	4
Details	binding site for residue LMN A 802

Chain	Residue
A	LEU45
A	TYR249
A	TRP257
A	LMN801

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	267
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"32610138","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33106659","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WQZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WR4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7JLO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7JLP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7JLQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	723
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	30
Details	Intramembrane: {"evidences":[{"source":"PubMed","id":"32610138","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33106659","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WQZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WR4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7JLP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7JLQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	24
Details	Intramembrane: {"evidences":[{"source":"PubMed","id":"32610138","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33106659","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WQZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WR4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7JLO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7JLP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7JLQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	24
Details	Topological domain: {"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	27
Details	Intramembrane: {"evidences":[{"source":"PubMed","id":"32610138","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WQZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	24
Details	Intramembrane: {"evidences":[{"source":"PubMed","id":"32610138","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33106659","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WQZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7JLP","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---