6WP2
The Crystal Structure of Apo Zinc-Bound Domain Swapped-Trimer Q108K:K40D:T53A:R58L:Q38F:Q4F:F57H Variant of HCRBPII
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001523 | biological_process | retinoid metabolic process |
| A | 0005501 | molecular_function | retinoid binding |
| A | 0005504 | molecular_function | fatty acid binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006776 | biological_process | vitamin A metabolic process |
| A | 0008289 | molecular_function | lipid binding |
| A | 0008544 | biological_process | epidermis development |
| A | 0015908 | biological_process | fatty acid transport |
| A | 0016918 | molecular_function | retinal binding |
| A | 0019432 | biological_process | triglyceride biosynthetic process |
| A | 0019841 | molecular_function | retinol binding |
| A | 0140104 | molecular_function | molecular carrier activity |
| B | 0001523 | biological_process | retinoid metabolic process |
| B | 0005501 | molecular_function | retinoid binding |
| B | 0005504 | molecular_function | fatty acid binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006776 | biological_process | vitamin A metabolic process |
| B | 0008289 | molecular_function | lipid binding |
| B | 0008544 | biological_process | epidermis development |
| B | 0015908 | biological_process | fatty acid transport |
| B | 0016918 | molecular_function | retinal binding |
| B | 0019432 | biological_process | triglyceride biosynthetic process |
| B | 0019841 | molecular_function | retinol binding |
| B | 0140104 | molecular_function | molecular carrier activity |
| C | 0001523 | biological_process | retinoid metabolic process |
| C | 0005501 | molecular_function | retinoid binding |
| C | 0005504 | molecular_function | fatty acid binding |
| C | 0005634 | cellular_component | nucleus |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006776 | biological_process | vitamin A metabolic process |
| C | 0008289 | molecular_function | lipid binding |
| C | 0008544 | biological_process | epidermis development |
| C | 0015908 | biological_process | fatty acid transport |
| C | 0016918 | molecular_function | retinal binding |
| C | 0019432 | biological_process | triglyceride biosynthetic process |
| C | 0019841 | molecular_function | retinol binding |
| C | 0140104 | molecular_function | molecular carrier activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue ZN A 201 |
| Chain | Residue |
| A | HIS57 |
| A | ZN203 |
| A | ZN204 |
| B | HIS57 |
| C | HIS57 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 203 |
| Chain | Residue |
| A | HIS57 |
| A | ZN201 |
| B | HIS57 |
| C | HIS57 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue ZN A 204 |
| Chain | Residue |
| A | ILE32 |
| A | HIS57 |
| A | ZN201 |
| B | HIS57 |
| C | ILE32 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | binding site for residue ZN A 205 |
| Chain | Residue |
| A | MET10 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 206 |
| Chain | Residue |
| A | TYR60 |
| A | GLU72 |
| A | TRP106 |
| A | LYS108 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | binding site for residue GOL A 207 |
| Chain | Residue |
| A | ASN13 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 201 |
| Chain | Residue |
| A | PHE27 |
| A | ALA28 |
| B | ARG2 |
| B | PHE27 |
| B | GLN44 |
| C | ZN201 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 202 |
| Chain | Residue |
| B | MET10 |
| B | GLU11 |
| B | SER12 |
| B | ASN13 |
| B | LEU36 |
| B | THR37 |
| B | LEU58 |
| site_id | AC9 |
| Number of Residues | 1 |
| Details | binding site for residue ZN C 201 |
| Chain | Residue |
| B | GOL201 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue ACT C 203 |
| Chain | Residue |
| C | MET10 |
| C | GLU11 |
| C | THR37 |
| C | LEU58 |
Functional Information from PROSITE/UniProt
| site_id | PS00214 |
| Number of Residues | 18 |
| Details | FABP Cytosolic fatty-acid binding proteins signature. GTWeMesNeNFEgYMKAL |
| Chain | Residue | Details |
| A | GLY6-LEU23 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"18076076","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
