6WNG
Crystal structure of an aspartate ammonia-lyase from Elizabethkingia anophelis NUHP1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0006099 | biological_process | tricarboxylic acid cycle |
| A | 0006520 | biological_process | amino acid metabolic process |
| A | 0006531 | biological_process | aspartate metabolic process |
| A | 0008797 | molecular_function | aspartate ammonia-lyase activity |
| A | 0016829 | molecular_function | lyase activity |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0006099 | biological_process | tricarboxylic acid cycle |
| B | 0006520 | biological_process | amino acid metabolic process |
| B | 0006531 | biological_process | aspartate metabolic process |
| B | 0008797 | molecular_function | aspartate ammonia-lyase activity |
| B | 0016829 | molecular_function | lyase activity |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0006099 | biological_process | tricarboxylic acid cycle |
| C | 0006520 | biological_process | amino acid metabolic process |
| C | 0006531 | biological_process | aspartate metabolic process |
| C | 0008797 | molecular_function | aspartate ammonia-lyase activity |
| C | 0016829 | molecular_function | lyase activity |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0006099 | biological_process | tricarboxylic acid cycle |
| D | 0006520 | biological_process | amino acid metabolic process |
| D | 0006531 | biological_process | aspartate metabolic process |
| D | 0008797 | molecular_function | aspartate ammonia-lyase activity |
| D | 0016829 | molecular_function | lyase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | binding site for residue TRS A 501 |
| Chain | Residue |
| A | ALA308 |
| A | HOH734 |
| A | HOH768 |
| A | HOH926 |
| A | ASN319 |
| A | LEU320 |
| A | LYS322 |
| A | VAL334 |
| A | ASN335 |
| A | PRO336 |
| A | HOH603 |
| A | HOH673 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | binding site for residue FUM A 502 |
| Chain | Residue |
| A | GLY326 |
| A | SER327 |
| A | SER328 |
| A | ILE329 |
| A | MET330 |
| A | LYS333 |
| A | ASN335 |
| B | THR110 |
| B | SER149 |
| B | THR150 |
| B | ASN151 |
| D | THR196 |
| D | GLN197 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 503 |
| Chain | Residue |
| A | GLU15 |
| A | SER16 |
| A | VAL32 |
| A | GLN33 |
| A | GLU118 |
| A | TYR135 |
| A | HOH767 |
| A | HOH901 |
| A | HOH932 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue CL A 504 |
| Chain | Residue |
| A | GLN197 |
| C | HOH770 |
| D | ARG305 |
| D | GLU340 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 505 |
| Chain | Residue |
| A | ARG383 |
| A | LYS386 |
| A | HOH778 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue CL A 506 |
| Chain | Residue |
| A | HIS51 |
| A | PRO52 |
| A | GLU53 |
| A | HOH706 |
| A | HOH1043 |
| site_id | AC7 |
| Number of Residues | 12 |
| Details | binding site for residue TRS B 501 |
| Chain | Residue |
| B | ALA308 |
| B | ILE318 |
| B | ASN319 |
| B | LEU320 |
| B | VAL334 |
| B | ASN335 |
| B | PRO336 |
| B | HOH601 |
| B | HOH669 |
| B | HOH734 |
| B | HOH765 |
| C | GLN199 |
| site_id | AC8 |
| Number of Residues | 13 |
| Details | binding site for residue FUM B 502 |
| Chain | Residue |
| A | THR110 |
| A | SER149 |
| A | THR150 |
| A | ASN151 |
| B | GLY326 |
| B | SER327 |
| B | SER328 |
| B | ILE329 |
| B | MET330 |
| B | LYS333 |
| B | ASN335 |
| C | THR196 |
| C | GLN197 |
| site_id | AC9 |
| Number of Residues | 8 |
| Details | binding site for residue GOL B 503 |
| Chain | Residue |
| B | SER16 |
| B | ASP17 |
| B | GLN33 |
| B | GLU118 |
| B | TYR135 |
| B | HOH650 |
| B | HOH743 |
| B | HOH983 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue CL B 504 |
| Chain | Residue |
| B | GLN197 |
| C | ARG305 |
| C | GLU340 |
| D | HOH655 |
| site_id | AD2 |
| Number of Residues | 3 |
| Details | binding site for residue CL B 505 |
| Chain | Residue |
| B | ARG383 |
| B | LYS386 |
| B | HOH837 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue CL B 506 |
| Chain | Residue |
| B | HIS51 |
| B | PRO52 |
| B | GLU53 |
| B | HOH771 |
| B | HOH1047 |
| site_id | AD4 |
| Number of Residues | 12 |
| Details | binding site for residue TRS C 601 |
| Chain | Residue |
| C | HOH701 |
| C | HOH781 |
| C | HOH932 |
| C | HOH962 |
| B | GLN199 |
| C | ALA308 |
| C | ILE318 |
| C | ASN319 |
| C | LEU320 |
| C | VAL334 |
| C | ASN335 |
| C | PRO336 |
| site_id | AD5 |
| Number of Residues | 13 |
| Details | binding site for residue FUM C 602 |
| Chain | Residue |
| B | THR196 |
| B | GLN197 |
| C | GLY326 |
| C | SER327 |
| C | SER328 |
| C | ILE329 |
| C | MET330 |
| C | LYS333 |
| C | ASN335 |
| D | THR110 |
| D | SER149 |
| D | THR150 |
| D | ASN151 |
| site_id | AD6 |
| Number of Residues | 9 |
| Details | binding site for residue GOL C 603 |
| Chain | Residue |
| C | SER16 |
| C | ASP17 |
| C | GLN33 |
| C | MET114 |
| C | GLU118 |
| C | TYR135 |
| C | HOH721 |
| C | HOH779 |
| C | HOH1050 |
| site_id | AD7 |
| Number of Residues | 4 |
| Details | binding site for residue CL C 604 |
| Chain | Residue |
| A | HOH676 |
| B | ARG305 |
| B | GLU340 |
| C | GLN197 |
| site_id | AD8 |
| Number of Residues | 3 |
| Details | binding site for residue CL C 605 |
| Chain | Residue |
| C | ARG383 |
| C | LYS386 |
| C | HOH934 |
| site_id | AD9 |
| Number of Residues | 5 |
| Details | binding site for residue CL C 606 |
| Chain | Residue |
| C | HIS51 |
| C | PRO52 |
| C | GLU53 |
| C | HOH832 |
| C | HOH1148 |
| site_id | AE1 |
| Number of Residues | 14 |
| Details | binding site for residue TRS D 501 |
| Chain | Residue |
| A | GLN199 |
| D | ALA308 |
| D | ILE318 |
| D | ASN319 |
| D | LEU320 |
| D | LYS322 |
| D | VAL334 |
| D | ASN335 |
| D | PRO336 |
| D | HOH601 |
| D | HOH625 |
| D | HOH797 |
| D | HOH803 |
| D | HOH850 |
| site_id | AE2 |
| Number of Residues | 13 |
| Details | binding site for residue FUM D 502 |
| Chain | Residue |
| A | THR196 |
| A | GLN197 |
| C | THR110 |
| C | SER149 |
| C | THR150 |
| C | ASN151 |
| D | GLY326 |
| D | SER327 |
| D | SER328 |
| D | ILE329 |
| D | MET330 |
| D | LYS333 |
| D | ASN335 |
| site_id | AE3 |
| Number of Residues | 9 |
| Details | binding site for residue GOL D 503 |
| Chain | Residue |
| D | SER16 |
| D | ASP17 |
| D | GLN33 |
| D | MET114 |
| D | GLU118 |
| D | TYR135 |
| D | HOH662 |
| D | HOH783 |
| D | HOH852 |
| site_id | AE4 |
| Number of Residues | 4 |
| Details | binding site for residue CL D 504 |
| Chain | Residue |
| A | ARG305 |
| A | GLU340 |
| B | HOH656 |
| D | GLN197 |
| site_id | AE5 |
| Number of Residues | 3 |
| Details | binding site for residue CL D 505 |
| Chain | Residue |
| D | ARG383 |
| D | LYS386 |
| D | HOH840 |
| site_id | AE6 |
| Number of Residues | 5 |
| Details | binding site for residue CL D 506 |
| Chain | Residue |
| D | HIS51 |
| D | PRO52 |
| D | GLU53 |
| D | HOH787 |
| D | HOH1013 |
Functional Information from PROSITE/UniProt
| site_id | PS00163 |
| Number of Residues | 10 |
| Details | FUMARATE_LYASES Fumarate lyases signature. GSsiMpGKvN |
| Chain | Residue | Details |
| A | GLY326-ASN335 |
