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6WML

Human TLR8 bound to the potent agonist, GS-9688 (Selgantolimod)

Functional Information from GO Data
ChainGOidnamespacecontents
A0002224biological_processtoll-like receptor signaling pathway
A0004888molecular_functiontransmembrane signaling receptor activity
A0006955biological_processimmune response
A0016020cellular_componentmembrane
B0002224biological_processtoll-like receptor signaling pathway
B0004888molecular_functiontransmembrane signaling receptor activity
B0006955biological_processimmune response
B0016020cellular_componentmembrane
C0002224biological_processtoll-like receptor signaling pathway
C0004888molecular_functiontransmembrane signaling receptor activity
C0006955biological_processimmune response
C0016020cellular_componentmembrane
D0002224biological_processtoll-like receptor signaling pathway
D0004888molecular_functiontransmembrane signaling receptor activity
D0006955biological_processimmune response
D0016020cellular_componentmembrane
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218
ChainResidueDetails
AGLY62
ALEU70
BGLY62
BLEU70
CGLY62
CLEU70
DGLY62
DLEU70

site_idSWS_FT_FI2
Number of Residues40
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN97
AGLU734
BASN97
BSER142
BLEU229
BCYS267
BGLU340
BLEU344
BTHR398
BLEU425
BASN564
ASER142
BGLU734
CASN97
CSER142
CLEU229
CCYS267
CGLU340
CLEU344
CTHR398
CLEU425
CASN564
ALEU229
CGLU734
DASN97
DSER142
DLEU229
DCYS267
DGLU340
DLEU344
DTHR398
DLEU425
DASN564
ACYS267
DGLU734
AGLU340
ALEU344
ATHR398
ALEU425
AASN564

site_idSWS_FT_FI3
Number of Residues28
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:23520111
ChainResidueDetails
ASER275
BILE493
BALA528
BGLY572
BILE622
BLEU662
CSER275
CTYR377
CILE493
CALA528
CGLY572
ATYR377
CILE622
CLEU662
DSER275
DTYR377
DILE493
DALA528
DGLY572
DILE622
DLEU662
AILE493
AALA528
AGLY572
AILE622
ALEU662
BSER275
BTYR377

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PDB entries from 2024-11-06

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