6WML
Human TLR8 bound to the potent agonist, GS-9688 (Selgantolimod)
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0002224 | biological_process | toll-like receptor signaling pathway |
A | 0004888 | molecular_function | transmembrane signaling receptor activity |
A | 0006955 | biological_process | immune response |
A | 0016020 | cellular_component | membrane |
B | 0002224 | biological_process | toll-like receptor signaling pathway |
B | 0004888 | molecular_function | transmembrane signaling receptor activity |
B | 0006955 | biological_process | immune response |
B | 0016020 | cellular_component | membrane |
C | 0002224 | biological_process | toll-like receptor signaling pathway |
C | 0004888 | molecular_function | transmembrane signaling receptor activity |
C | 0006955 | biological_process | immune response |
C | 0016020 | cellular_component | membrane |
D | 0002224 | biological_process | toll-like receptor signaling pathway |
D | 0004888 | molecular_function | transmembrane signaling receptor activity |
D | 0006955 | biological_process | immune response |
D | 0016020 | cellular_component | membrane |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 8 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218 |
Chain | Residue | Details |
A | GLY62 | |
A | LEU70 | |
B | GLY62 | |
B | LEU70 | |
C | GLY62 | |
C | LEU70 | |
D | GLY62 | |
D | LEU70 |
site_id | SWS_FT_FI2 |
Number of Residues | 40 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
Chain | Residue | Details |
A | ASN97 | |
A | GLU734 | |
B | ASN97 | |
B | SER142 | |
B | LEU229 | |
B | CYS267 | |
B | GLU340 | |
B | LEU344 | |
B | THR398 | |
B | LEU425 | |
B | ASN564 | |
A | SER142 | |
B | GLU734 | |
C | ASN97 | |
C | SER142 | |
C | LEU229 | |
C | CYS267 | |
C | GLU340 | |
C | LEU344 | |
C | THR398 | |
C | LEU425 | |
C | ASN564 | |
A | LEU229 | |
C | GLU734 | |
D | ASN97 | |
D | SER142 | |
D | LEU229 | |
D | CYS267 | |
D | GLU340 | |
D | LEU344 | |
D | THR398 | |
D | LEU425 | |
D | ASN564 | |
A | CYS267 | |
D | GLU734 | |
A | GLU340 | |
A | LEU344 | |
A | THR398 | |
A | LEU425 | |
A | ASN564 |
site_id | SWS_FT_FI3 |
Number of Residues | 28 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:23520111 |
Chain | Residue | Details |
A | SER275 | |
B | ILE493 | |
B | ALA528 | |
B | GLY572 | |
B | ILE622 | |
B | LEU662 | |
C | SER275 | |
C | TYR377 | |
C | ILE493 | |
C | ALA528 | |
C | GLY572 | |
A | TYR377 | |
C | ILE622 | |
C | LEU662 | |
D | SER275 | |
D | TYR377 | |
D | ILE493 | |
D | ALA528 | |
D | GLY572 | |
D | ILE622 | |
D | LEU662 | |
A | ILE493 | |
A | ALA528 | |
A | GLY572 | |
A | ILE622 | |
A | LEU662 | |
B | SER275 | |
B | TYR377 |