6WJV

Structure of the Saccharomyces cerevisiae polymerase epsilon holoenzyme

Functional Information from GO Data

Chain	GOid	namespace	contents
2	0003677	molecular_function	DNA binding
2	0003690	molecular_function	double-stranded DNA binding
2	0003697	molecular_function	single-stranded DNA binding
2	0003887	molecular_function	DNA-directed DNA polymerase activity
2	0005515	molecular_function	protein binding
2	0005634	cellular_component	nucleus
2	0005737	cellular_component	cytoplasm
2	0006260	biological_process	DNA replication
2	0006261	biological_process	DNA-templated DNA replication
2	0008622	cellular_component	epsilon DNA polymerase complex
2	0030337	molecular_function	DNA polymerase processivity factor activity
2	0042276	biological_process	error-prone translesion synthesis
2	0043596	cellular_component	nuclear replication fork
2	0045005	biological_process	DNA-templated DNA replication maintenance of fidelity
3	0003690	molecular_function	double-stranded DNA binding
3	0003697	molecular_function	single-stranded DNA binding
3	0005515	molecular_function	protein binding
3	0005634	cellular_component	nucleus
3	0006260	biological_process	DNA replication
3	0006261	biological_process	DNA-templated DNA replication
3	0006272	biological_process	leading strand elongation
3	0008310	molecular_function	single-stranded DNA 3'-5' DNA exonuclease activity
3	0008622	cellular_component	epsilon DNA polymerase complex
3	0008623	cellular_component	CHRAC
3	0030337	molecular_function	DNA polymerase processivity factor activity
3	0032991	cellular_component	protein-containing complex
3	0042276	biological_process	error-prone translesion synthesis
3	0043596	cellular_component	nuclear replication fork
3	0046982	molecular_function	protein heterodimerization activity
4	0003690	molecular_function	double-stranded DNA binding
4	0003697	molecular_function	single-stranded DNA binding
4	0005515	molecular_function	protein binding
4	0005634	cellular_component	nucleus
4	0006260	biological_process	DNA replication
4	0006261	biological_process	DNA-templated DNA replication
4	0006272	biological_process	leading strand elongation
4	0006338	biological_process	chromatin remodeling
4	0006355	biological_process	regulation of DNA-templated transcription
4	0006974	biological_process	DNA damage response
4	0008310	molecular_function	single-stranded DNA 3'-5' DNA exonuclease activity
4	0008622	cellular_component	epsilon DNA polymerase complex
4	0008623	cellular_component	CHRAC
4	0030337	molecular_function	DNA polymerase processivity factor activity
4	0031490	molecular_function	chromatin DNA binding
4	0031492	molecular_function	nucleosomal DNA binding
4	0031507	biological_process	heterochromatin formation
4	0032991	cellular_component	protein-containing complex
4	0042276	biological_process	error-prone translesion synthesis
4	0043596	cellular_component	nuclear replication fork
4	0046982	molecular_function	protein heterodimerization activity
4	1903775	biological_process	regulation of DNA double-strand break processing
A	0000166	molecular_function	nucleotide binding
A	0000278	biological_process	mitotic cell cycle
A	0003676	molecular_function	nucleic acid binding
A	0003677	molecular_function	DNA binding
A	0003690	molecular_function	double-stranded DNA binding
A	0003697	molecular_function	single-stranded DNA binding
A	0003729	molecular_function	mRNA binding
A	0003887	molecular_function	DNA-directed DNA polymerase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005657	cellular_component	replication fork
A	0006260	biological_process	DNA replication
A	0006261	biological_process	DNA-templated DNA replication
A	0006272	biological_process	leading strand elongation
A	0006281	biological_process	DNA repair
A	0006284	biological_process	base-excision repair
A	0006287	biological_process	base-excision repair, gap-filling
A	0006297	biological_process	nucleotide-excision repair, DNA gap filling
A	0006302	biological_process	double-strand break repair
A	0006303	biological_process	double-strand break repair via nonhomologous end joining
A	0007064	biological_process	mitotic sister chromatid cohesion
A	0008270	molecular_function	zinc ion binding
A	0008310	molecular_function	single-stranded DNA 3'-5' DNA exonuclease activity
A	0008622	cellular_component	epsilon DNA polymerase complex
A	0016787	molecular_function	hydrolase activity
A	0031573	biological_process	mitotic intra-S DNA damage checkpoint signaling
A	0032183	molecular_function	SUMO binding
A	0033314	biological_process	mitotic DNA replication checkpoint signaling
A	0035822	biological_process	gene conversion
A	0042276	biological_process	error-prone translesion synthesis
A	0043231	cellular_component	intracellular membrane-bounded organelle
A	0043596	cellular_component	nuclear replication fork
A	0045004	biological_process	DNA replication proofreading
A	0046872	molecular_function	metal ion binding
A	0051539	molecular_function	4 iron, 4 sulfur cluster binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 3001

Chain	Residue
A	CYS2108
A	CYS2111
A	CYS2130
A	CYS2133

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Phosphoserine; by ATM or ATR => ECO:0007744|PubMed:18407956

Chain	Residue	Details
4	SER183

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site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19779198

Chain	Residue	Details
3	SER188
3	SER189
A	CYS2130
A	CYS2133
A	CYS2164
A	CYS2167
A	CYS2179
A	CYS2181

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:14747467

Chain	Residue	Details
2	SER613

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