6WHG

PI3P and calcium bound full-length TRPY1 in detergent

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000324	cellular_component	fungal-type vacuole
A	0000329	cellular_component	fungal-type vacuole membrane
A	0005227	molecular_function	calcium-activated cation channel activity
A	0005244	molecular_function	voltage-gated monoatomic ion channel activity
A	0005262	molecular_function	calcium channel activity
A	0005267	molecular_function	potassium channel activity
A	0005272	molecular_function	sodium channel activity
A	0005774	cellular_component	vacuolar membrane
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006816	biological_process	calcium ion transport
A	0030003	biological_process	intracellular monoatomic cation homeostasis
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0035725	biological_process	sodium ion transmembrane transport
A	0070588	biological_process	calcium ion transmembrane transport
A	0071805	biological_process	potassium ion transmembrane transport
A	0097553	biological_process	calcium ion transmembrane import into cytosol
A	0098703	biological_process	calcium ion import across plasma membrane
A	1990816	cellular_component	vacuole-mitochondrion membrane contact site
B	0000324	cellular_component	fungal-type vacuole
B	0000329	cellular_component	fungal-type vacuole membrane
B	0005227	molecular_function	calcium-activated cation channel activity
B	0005244	molecular_function	voltage-gated monoatomic ion channel activity
B	0005262	molecular_function	calcium channel activity
B	0005267	molecular_function	potassium channel activity
B	0005272	molecular_function	sodium channel activity
B	0005774	cellular_component	vacuolar membrane
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0006816	biological_process	calcium ion transport
B	0030003	biological_process	intracellular monoatomic cation homeostasis
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0035725	biological_process	sodium ion transmembrane transport
B	0070588	biological_process	calcium ion transmembrane transport
B	0071805	biological_process	potassium ion transmembrane transport
B	0097553	biological_process	calcium ion transmembrane import into cytosol
B	0098703	biological_process	calcium ion import across plasma membrane
B	1990816	cellular_component	vacuole-mitochondrion membrane contact site
C	0000324	cellular_component	fungal-type vacuole
C	0000329	cellular_component	fungal-type vacuole membrane
C	0005227	molecular_function	calcium-activated cation channel activity
C	0005244	molecular_function	voltage-gated monoatomic ion channel activity
C	0005262	molecular_function	calcium channel activity
C	0005267	molecular_function	potassium channel activity
C	0005272	molecular_function	sodium channel activity
C	0005774	cellular_component	vacuolar membrane
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0006816	biological_process	calcium ion transport
C	0030003	biological_process	intracellular monoatomic cation homeostasis
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0035725	biological_process	sodium ion transmembrane transport
C	0070588	biological_process	calcium ion transmembrane transport
C	0071805	biological_process	potassium ion transmembrane transport
C	0097553	biological_process	calcium ion transmembrane import into cytosol
C	0098703	biological_process	calcium ion import across plasma membrane
C	1990816	cellular_component	vacuole-mitochondrion membrane contact site
D	0000324	cellular_component	fungal-type vacuole
D	0000329	cellular_component	fungal-type vacuole membrane
D	0005227	molecular_function	calcium-activated cation channel activity
D	0005244	molecular_function	voltage-gated monoatomic ion channel activity
D	0005262	molecular_function	calcium channel activity
D	0005267	molecular_function	potassium channel activity
D	0005272	molecular_function	sodium channel activity
D	0005774	cellular_component	vacuolar membrane
D	0005886	cellular_component	plasma membrane
D	0006811	biological_process	monoatomic ion transport
D	0006816	biological_process	calcium ion transport
D	0030003	biological_process	intracellular monoatomic cation homeostasis
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0035725	biological_process	sodium ion transmembrane transport
D	0070588	biological_process	calcium ion transmembrane transport
D	0071805	biological_process	potassium ion transmembrane transport
D	0097553	biological_process	calcium ion transmembrane import into cytosol
D	0098703	biological_process	calcium ion import across plasma membrane
D	1990816	cellular_component	vacuole-mitochondrion membrane contact site

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue CA A 701

Chain	Residue
A	ASP398
A	ASP401
A	LYS403
A	ASP405

---

site_id	AC2
Number of Residues	5
Details	binding site for residue CA A 702

Chain	Residue
A	ASP562
A	THR563
A	ASP566
A	ASP569
D	ASN161

---

site_id	AC3
Number of Residues	15
Details	binding site for residue PWE A 703

Chain	Residue
A	SER297
A	PHE298
A	TRP299
A	ASN300
A	PRO346
A	PHE347
A	SER350
A	LEU354
A	GLU357
A	LEU366
A	LYS370
A	LEU476
A	GLN479
A	ARG483
D	PHE390

---

site_id	AC4
Number of Residues	4
Details	binding site for residue CA B 701

Chain	Residue
B	ASP398
B	ASP401
B	LYS403
B	ASP405

---

site_id	AC5
Number of Residues	5
Details	binding site for residue CA B 702

Chain	Residue
A	ASN161
B	ASP562
B	THR563
B	ASP566
B	ASP569

---

site_id	AC6
Number of Residues	16
Details	binding site for residue PWE B 703

Chain	Residue
A	PHE390
A	ILE445
B	SER297
B	PHE298
B	TRP299
B	ASN300
B	PRO346
B	PHE347
B	SER350
B	LEU354
B	GLU357
B	LEU366
B	LYS370
B	LEU476
B	GLN479
B	ARG483

---

site_id	AC7
Number of Residues	4
Details	binding site for residue CA C 701

Chain	Residue
C	ASP398
C	ASP401
C	LYS403
C	ASP405

---

site_id	AC8
Number of Residues	5
Details	binding site for residue CA C 702

Chain	Residue
B	ASN161
C	ASP562
C	THR563
C	ASP566
C	ASP569

---

site_id	AC9
Number of Residues	15
Details	binding site for residue PWE C 703

Chain	Residue
B	PHE390
C	SER297
C	PHE298
C	TRP299
C	ASN300
C	PRO346
C	PHE347
C	SER350
C	LEU354
C	GLU357
C	LEU366
C	LYS370
C	LEU476
C	GLN479
C	ARG483

---

site_id	AD1
Number of Residues	4
Details	binding site for residue CA D 701

Chain	Residue
D	ASP398
D	ASP401
D	LYS403
D	ASP405

---

site_id	AD2
Number of Residues	5
Details	binding site for residue CA D 702

Chain	Residue
C	ASN161
D	ASP562
D	THR563
D	ASP566
D	ASP569

---

site_id	AD3
Number of Residues	15
Details	binding site for residue PWE D 703

Chain	Residue
C	PHE390
D	SER297
D	PHE298
D	TRP299
D	ASN300
D	PRO346
D	PHE347
D	SER350
D	LEU354
D	GLU357
D	LEU366
D	LYS370
D	LEU476
D	GLN479
D	ARG483

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	476
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	264
Details	Topological domain: {"description":"Vacuolar","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	28
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---