6WH5

Mycobacterium tuberculosis pduO-type ATP:cobalamin adenosyltransferase bound to cob(II)alamin and PPPi

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0006779	biological_process	porphyrin-containing compound biosynthetic process
A	0008817	molecular_function	corrinoid adenosyltransferase activity
A	0009236	biological_process	cobalamin biosynthetic process
A	0016740	molecular_function	transferase activity
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0006779	biological_process	porphyrin-containing compound biosynthetic process
B	0008817	molecular_function	corrinoid adenosyltransferase activity
B	0009236	biological_process	cobalamin biosynthetic process
B	0016740	molecular_function	transferase activity
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0006779	biological_process	porphyrin-containing compound biosynthetic process
C	0008817	molecular_function	corrinoid adenosyltransferase activity
C	0009236	biological_process	cobalamin biosynthetic process
C	0016740	molecular_function	transferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue K A 201

Chain	Residue
A	ASP167
C	ILE8
C	3PO203
C	B12205

---

site_id	AC2
Number of Residues	4
Details	binding site for residue MG A 202

Chain	Residue
A	ASN163
A	HOH317
A	HOH326
C	3PO203

---

site_id	AC3
Number of Residues	19
Details	binding site for residue 3PO A 203

Chain	Residue
A	ARG11
A	THR12
A	GLY13
A	THR17
A	THR18
A	LYS28
A	B12204
A	HOH303
A	HOH307
A	HOH324
B	ARG137
B	ASN163
B	ASP167
B	K201
B	MG202
B	HOH307
B	HOH317
B	HOH329
A	THR10

---

site_id	AC4
Number of Residues	28
Details	binding site for residue B12 A 204

Chain	Residue
A	VAL3
A	HIS4
A	LEU5
A	THR6
A	ARG7
A	ILE8
A	GLY19
A	SER21
A	MET23
A	TYR36
A	PHE71
A	GLY74
A	ALA75
A	SER78
A	PRO88
A	PRO89
A	LEU90
A	3PO203
A	HOH337
B	ARG7
B	PHE117
B	VAL118
B	ARG133
B	ARG137
B	SER166
B	ASP167
B	PHE170
B	K201

---

site_id	AC5
Number of Residues	4
Details	binding site for residue K B 201

Chain	Residue
A	ILE8
A	3PO203
A	B12204
B	ASP167

---

site_id	AC6
Number of Residues	4
Details	binding site for residue MG B 202

Chain	Residue
A	3PO203
B	ASN163
B	HOH317
B	HOH329

---

site_id	AC7
Number of Residues	18
Details	binding site for residue 3PO B 203

Chain	Residue
B	THR10
B	ARG11
B	THR12
B	GLY13
B	THR18
B	LYS28
B	HOH305
B	HOH330
B	HOH336
C	ARG137
C	ASN163
C	ASP167
C	K201
C	MG202
C	B12204
C	HOH307
C	HOH309
C	HOH326

---

site_id	AC8
Number of Residues	4
Details	binding site for residue K C 201

Chain	Residue
B	ILE8
B	3PO203
C	ASP167
C	B12204

---

site_id	AC9
Number of Residues	4
Details	binding site for residue MG C 202

Chain	Residue
B	3PO203
C	ASN163
C	HOH307
C	HOH326

---

site_id	AD1
Number of Residues	19
Details	binding site for residue 3PO C 203

Chain	Residue
C	THR12
C	GLY13
C	THR17
C	THR18
C	LYS28
C	B12205
C	HOH310
C	HOH313
C	HOH319
A	ARG137
A	ASN163
A	ASP167
A	K201
A	MG202
A	HOH310
A	HOH317
A	HOH326
C	THR10
C	ARG11

---

site_id	AD2
Number of Residues	30
Details	binding site for residue B12 C 204

Chain	Residue
B	HIS4
B	LEU5
B	THR6
B	ARG7
B	ILE8
B	GLY19
B	SER21
B	MET23
B	TYR36
B	PHE71
B	GLY74
B	ALA75
B	SER78
B	THR79
B	PRO88
B	PRO89
B	LEU90
B	3PO203
B	HOH330
C	ARG7
C	PHE117
C	VAL118
C	ARG133
C	ARG137
C	SER166
C	ASP167
C	PHE170
C	K201
C	HOH301
C	HOH349

---

site_id	AD3
Number of Residues	31
Details	binding site for residue B12 C 205

Chain	Residue
A	ARG7
A	PHE117
A	VAL118
A	ARG133
A	ARG137
A	SER166
A	ASP167
A	PHE170
A	TRP184
A	K201
C	VAL3
C	HIS4
C	LEU5
C	THR6
C	ARG7
C	ILE8
C	GLY19
C	SER21
C	MET23
C	TYR36
C	PHE71
C	GLY74
C	ALA75
C	SER78
C	THR79
C	PRO88
C	PRO89
C	LEU90
C	3PO203
C	HOH362
C	HOH364

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	THR10
C	LYS28
C	ARG137
C	ASN163
A	LYS28
A	ARG137
A	ASN163
B	THR10
B	LYS28
B	ARG137
B	ASN163
C	THR10

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