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6WGC

Atomic model of semi-attached mutant OCCM-DNA complex (ORC-Cdc6-Cdt1-Mcm2-7 with Mcm6 WHD truncation)

Functional Information from GO Data
ChainGOidnamespacecontents
30000727biological_processdouble-strand break repair via break-induced replication
30000781cellular_componentchromosome, telomeric region
30003677molecular_functionDNA binding
30003682molecular_functionchromatin binding
30003688molecular_functionDNA replication origin binding
30003697molecular_functionsingle-stranded DNA binding
30004386molecular_functionhelicase activity
30005515molecular_functionprotein binding
30005524molecular_functionATP binding
30005634cellular_componentnucleus
30005654cellular_componentnucleoplasm
30005656cellular_componentnuclear pre-replicative complex
30005737cellular_componentcytoplasm
30006260biological_processDNA replication
30006267biological_processpre-replicative complex assembly involved in nuclear cell cycle DNA replication
30006268biological_processDNA unwinding involved in DNA replication
30006270biological_processDNA replication initiation
30006271biological_processDNA strand elongation involved in DNA replication
30006279biological_processpremeiotic DNA replication
30016787molecular_functionhydrolase activity
30016887molecular_functionATP hydrolysis activity
30017116molecular_functionsingle-stranded DNA helicase activity
30030466biological_processsilent mating-type cassette heterochromatin formation
30031261cellular_componentDNA replication preinitiation complex
30031298cellular_componentreplication fork protection complex
30031509biological_processsubtelomeric heterochromatin formation
30032508biological_processDNA duplex unwinding
30042555cellular_componentMCM complex
30043596cellular_componentnuclear replication fork
30071162cellular_componentCMG complex
31902975biological_processmitotic DNA replication initiation
31904931molecular_functionMCM complex binding
70000727biological_processdouble-strand break repair via break-induced replication
70000781cellular_componentchromosome, telomeric region
70003677molecular_functionDNA binding
70003678molecular_functionDNA helicase activity
70003682molecular_functionchromatin binding
70003688molecular_functionDNA replication origin binding
70003697molecular_functionsingle-stranded DNA binding
70004386molecular_functionhelicase activity
70005515molecular_functionprotein binding
70005524molecular_functionATP binding
70005634cellular_componentnucleus
70005654cellular_componentnucleoplasm
70005656cellular_componentnuclear pre-replicative complex
70005737cellular_componentcytoplasm
70006260biological_processDNA replication
70006267biological_processpre-replicative complex assembly involved in nuclear cell cycle DNA replication
70006268biological_processDNA unwinding involved in DNA replication
70006270biological_processDNA replication initiation
70006271biological_processDNA strand elongation involved in DNA replication
70006279biological_processpremeiotic DNA replication
70008270molecular_functionzinc ion binding
70009378molecular_functionfour-way junction helicase activity
70016787molecular_functionhydrolase activity
70016887molecular_functionATP hydrolysis activity
70017116molecular_functionsingle-stranded DNA helicase activity
70030466biological_processsilent mating-type cassette heterochromatin formation
70031261cellular_componentDNA replication preinitiation complex
70031298cellular_componentreplication fork protection complex
70031509biological_processsubtelomeric heterochromatin formation
70032508biological_processDNA duplex unwinding
70033260biological_processnuclear DNA replication
70042555cellular_componentMCM complex
70043138molecular_function3'-5' DNA helicase activity
70043596cellular_componentnuclear replication fork
70071162cellular_componentCMG complex
70097373cellular_componentMCM core complex
71904931molecular_functionMCM complex binding
90000082biological_processG1/S transition of mitotic cell cycle
90003682molecular_functionchromatin binding
90003688molecular_functionDNA replication origin binding
90003924molecular_functionGTPase activity
90004861molecular_functioncyclin-dependent protein serine/threonine kinase inhibitor activity
90005515molecular_functionprotein binding
90005524molecular_functionATP binding
90005525molecular_functionGTP binding
90005634cellular_componentnucleus
90005654cellular_componentnucleoplasm
90005656cellular_componentnuclear pre-replicative complex
90005694cellular_componentchromosome
90005737cellular_componentcytoplasm
90006260biological_processDNA replication
90006267biological_processpre-replicative complex assembly involved in nuclear cell cycle DNA replication
90006270biological_processDNA replication initiation
90016887molecular_functionATP hydrolysis activity
90030174biological_processregulation of DNA-templated DNA replication initiation
90031261cellular_componentDNA replication preinitiation complex
90033314biological_processmitotic DNA replication checkpoint signaling
90051301biological_processcell division
90140530biological_processMCM complex loading
A0003677molecular_functionDNA binding
A0003682molecular_functionchromatin binding
A0003688molecular_functionDNA replication origin binding
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005656cellular_componentnuclear pre-replicative complex
A0005664cellular_componentnuclear origin of replication recognition complex
A0005694cellular_componentchromosome
A0006260biological_processDNA replication
A0006267biological_processpre-replicative complex assembly involved in nuclear cell cycle DNA replication
A0006270biological_processDNA replication initiation
A0016887molecular_functionATP hydrolysis activity
A0030466biological_processsilent mating-type cassette heterochromatin formation
A0031261cellular_componentDNA replication preinitiation complex
A0031491molecular_functionnucleosome binding
A0032993cellular_componentprotein-DNA complex
A0033314biological_processmitotic DNA replication checkpoint signaling
A0034728biological_processnucleosome organization
A0043007biological_processmaintenance of rDNA
A0046872molecular_functionmetal ion binding
B0000781cellular_componentchromosome, telomeric region
B0000808cellular_componentorigin recognition complex
B0003682molecular_functionchromatin binding
B0003688molecular_functionDNA replication origin binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005656cellular_componentnuclear pre-replicative complex
B0005664cellular_componentnuclear origin of replication recognition complex
B0006260biological_processDNA replication
B0006267biological_processpre-replicative complex assembly involved in nuclear cell cycle DNA replication
B0006270biological_processDNA replication initiation
B0030466biological_processsilent mating-type cassette heterochromatin formation
B0031261cellular_componentDNA replication preinitiation complex
B0031509biological_processsubtelomeric heterochromatin formation
C0003677molecular_functionDNA binding
C0003682molecular_functionchromatin binding
C0003688molecular_functionDNA replication origin binding
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005656cellular_componentnuclear pre-replicative complex
C0005664cellular_componentnuclear origin of replication recognition complex
C0006260biological_processDNA replication
C0006267biological_processpre-replicative complex assembly involved in nuclear cell cycle DNA replication
C0006270biological_processDNA replication initiation
C0030466biological_processsilent mating-type cassette heterochromatin formation
C0031261cellular_componentDNA replication preinitiation complex
D0000808cellular_componentorigin recognition complex
D0003677molecular_functionDNA binding
D0003688molecular_functionDNA replication origin binding
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005656cellular_componentnuclear pre-replicative complex
D0005664cellular_componentnuclear origin of replication recognition complex
D0006260biological_processDNA replication
D0006267biological_processpre-replicative complex assembly involved in nuclear cell cycle DNA replication
D0006270biological_processDNA replication initiation
D0030466biological_processsilent mating-type cassette heterochromatin formation
D0031261cellular_componentDNA replication preinitiation complex
E0000808cellular_componentorigin recognition complex
E0003688molecular_functionDNA replication origin binding
E0005515molecular_functionprotein binding
E0005524molecular_functionATP binding
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0005656cellular_componentnuclear pre-replicative complex
E0005664cellular_componentnuclear origin of replication recognition complex
E0006260biological_processDNA replication
E0006267biological_processpre-replicative complex assembly involved in nuclear cell cycle DNA replication
E0006270biological_processDNA replication initiation
E0006275biological_processregulation of DNA replication
E0030466biological_processsilent mating-type cassette heterochromatin formation
E0031261cellular_componentDNA replication preinitiation complex
E0035361cellular_componentCul8-RING ubiquitin ligase complex
F0003677molecular_functionDNA binding
F0003688molecular_functionDNA replication origin binding
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005656cellular_componentnuclear pre-replicative complex
F0005664cellular_componentnuclear origin of replication recognition complex
F0006260biological_processDNA replication
F0006267biological_processpre-replicative complex assembly involved in nuclear cell cycle DNA replication
F0006270biological_processDNA replication initiation
F0030466biological_processsilent mating-type cassette heterochromatin formation
F0031261cellular_componentDNA replication preinitiation complex
Functional Information from PDB Data
site_idAC1
Number of Residues13
Detailsbinding site for residue AGS 9 2001
ChainResidue
9THR82
9ASP330
9LYS333
ASER615
AARG616
9PRO109
9PRO110
9GLY111
9GLY113
9LYS114
9THR115
9ALA116
9ILE299

site_idAC2
Number of Residues16
Detailsbinding site for residue AGS A 2001
ChainResidue
ASER432
ALEU449
APRO481
AGLY482
AVAL483
AGLY484
ALYS485
ATHR486
ALEU487
AGLU567
ATYR627
AILE635
AARG639
AALA703
AARG704
DARG267

site_idAC3
Number of Residues12
Detailsbinding site for residue AGS E 2001
ChainResidue
EALA9
ETYR38
ESER39
EGLY40
ETHR41
EGLY42
ELYS43
ETHR44
ETYR45
ETYR192
EILE200
EPHE256

site_idAC4
Number of Residues12
Detailsbinding site for residue AGS D 2001
ChainResidue
DARG104
DGLN105
DSER106
DTYR107
DLYS108
DTHR109
DTYR110
DASP217
DGLU218
DLYS338
ELYS151
ELYS158

Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DLNQSKKMNvsEF
ChainResidueDetails
CASP3-PHE15

site_idPS00847
Number of Residues9
DetailsMCM_1 MCM family signature. GVVCIDEFD
ChainResidueDetails
3GLY458-ASP466
7GLY519-ASP527

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P33993
ChainResidueDetails
7TYR423
7GLY463
7ALA465
7LYS466
7SER467
7ASN568
7ARG593
7ARG687

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:18407956
ChainResidueDetails
7THR811

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18407956
ChainResidueDetails
7SER819

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:19779198
ChainResidueDetails
7SER838

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:17330950
ChainResidueDetails
3THR858

226707

PDB entries from 2024-10-30

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