Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6WGC

Atomic model of semi-attached mutant OCCM-DNA complex (ORC-Cdc6-Cdt1-Mcm2-7 with Mcm6 WHD truncation)

Functional Information from GO Data

Chain	GOid	namespace	contents
3	0000166	molecular_function	nucleotide binding
3	0000727	biological_process	double-strand break repair via break-induced replication
3	0000781	cellular_component	chromosome, telomeric region
3	0003677	molecular_function	DNA binding
3	0003678	molecular_function	DNA helicase activity
3	0003682	molecular_function	chromatin binding
3	0003688	molecular_function	DNA replication origin binding
3	0003697	molecular_function	single-stranded DNA binding
3	0004386	molecular_function	helicase activity
3	0005515	molecular_function	protein binding
3	0005524	molecular_function	ATP binding
3	0005634	cellular_component	nucleus
3	0005654	cellular_component	nucleoplasm
3	0005656	cellular_component	nuclear pre-replicative complex
3	0005737	cellular_component	cytoplasm
3	0006260	biological_process	DNA replication
3	0006267	biological_process	pre-replicative complex assembly involved in nuclear cell cycle DNA replication
3	0006270	biological_process	DNA replication initiation
3	0006271	biological_process	DNA strand elongation involved in DNA replication
3	0006279	biological_process	premeiotic DNA replication
3	0016787	molecular_function	hydrolase activity
3	0016887	molecular_function	ATP hydrolysis activity
3	0017116	molecular_function	single-stranded DNA helicase activity
3	0030466	biological_process	silent mating-type cassette heterochromatin formation
3	0031261	cellular_component	DNA replication preinitiation complex
3	0031509	biological_process	subtelomeric heterochromatin formation
3	0042555	cellular_component	MCM complex
3	0043596	cellular_component	nuclear replication fork
3	0071162	cellular_component	CMG complex
3	1902975	biological_process	mitotic DNA replication initiation
3	1904931	molecular_function	MCM complex binding
7	0000166	molecular_function	nucleotide binding
7	0000727	biological_process	double-strand break repair via break-induced replication
7	0000781	cellular_component	chromosome, telomeric region
7	0003677	molecular_function	DNA binding
7	0003678	molecular_function	DNA helicase activity
7	0003682	molecular_function	chromatin binding
7	0003688	molecular_function	DNA replication origin binding
7	0003697	molecular_function	single-stranded DNA binding
7	0004386	molecular_function	helicase activity
7	0005515	molecular_function	protein binding
7	0005524	molecular_function	ATP binding
7	0005634	cellular_component	nucleus
7	0005654	cellular_component	nucleoplasm
7	0005656	cellular_component	nuclear pre-replicative complex
7	0005737	cellular_component	cytoplasm
7	0006260	biological_process	DNA replication
7	0006267	biological_process	pre-replicative complex assembly involved in nuclear cell cycle DNA replication
7	0006270	biological_process	DNA replication initiation
7	0006271	biological_process	DNA strand elongation involved in DNA replication
7	0006279	biological_process	premeiotic DNA replication
7	0008270	molecular_function	zinc ion binding
7	0009378	molecular_function	four-way junction helicase activity
7	0016787	molecular_function	hydrolase activity
7	0016887	molecular_function	ATP hydrolysis activity
7	0017116	molecular_function	single-stranded DNA helicase activity
7	0030466	biological_process	silent mating-type cassette heterochromatin formation
7	0031261	cellular_component	DNA replication preinitiation complex
7	0031509	biological_process	subtelomeric heterochromatin formation
7	0033260	biological_process	nuclear DNA replication
7	0042555	cellular_component	MCM complex
7	0043138	molecular_function	3'-5' DNA helicase activity
7	0043596	cellular_component	nuclear replication fork
7	0071162	cellular_component	CMG complex
7	0097373	cellular_component	MCM core complex
7	1904931	molecular_function	MCM complex binding
9	0000082	biological_process	G1/S transition of mitotic cell cycle
9	0000166	molecular_function	nucleotide binding
9	0003682	molecular_function	chromatin binding
9	0003688	molecular_function	DNA replication origin binding
9	0003924	molecular_function	GTPase activity
9	0004861	molecular_function	cyclin-dependent protein serine/threonine kinase inhibitor activity
9	0005515	molecular_function	protein binding
9	0005524	molecular_function	ATP binding
9	0005525	molecular_function	GTP binding
9	0005634	cellular_component	nucleus
9	0005654	cellular_component	nucleoplasm
9	0005656	cellular_component	nuclear pre-replicative complex
9	0005694	cellular_component	chromosome
9	0005737	cellular_component	cytoplasm
9	0006260	biological_process	DNA replication
9	0006267	biological_process	pre-replicative complex assembly involved in nuclear cell cycle DNA replication
9	0006270	biological_process	DNA replication initiation
9	0016887	molecular_function	ATP hydrolysis activity
9	0030174	biological_process	regulation of DNA-templated DNA replication initiation
9	0031261	cellular_component	DNA replication preinitiation complex
9	0033314	biological_process	mitotic DNA replication checkpoint signaling
9	0051301	biological_process	cell division
9	0140530	biological_process	MCM complex loading
A	0000166	molecular_function	nucleotide binding
A	0003677	molecular_function	DNA binding
A	0003682	molecular_function	chromatin binding
A	0003688	molecular_function	DNA replication origin binding
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005656	cellular_component	nuclear pre-replicative complex
A	0005664	cellular_component	nuclear origin of replication recognition complex
A	0005694	cellular_component	chromosome
A	0006260	biological_process	DNA replication
A	0006267	biological_process	pre-replicative complex assembly involved in nuclear cell cycle DNA replication
A	0006270	biological_process	DNA replication initiation
A	0016887	molecular_function	ATP hydrolysis activity
A	0030466	biological_process	silent mating-type cassette heterochromatin formation
A	0031261	cellular_component	DNA replication preinitiation complex
A	0031491	molecular_function	nucleosome binding
A	0033314	biological_process	mitotic DNA replication checkpoint signaling
A	0034728	biological_process	nucleosome organization
A	0043007	biological_process	maintenance of rDNA
A	0046872	molecular_function	metal ion binding
B	0000781	cellular_component	chromosome, telomeric region
B	0000808	cellular_component	origin recognition complex
B	0003682	molecular_function	chromatin binding
B	0003688	molecular_function	DNA replication origin binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005656	cellular_component	nuclear pre-replicative complex
B	0005664	cellular_component	nuclear origin of replication recognition complex
B	0006260	biological_process	DNA replication
B	0006267	biological_process	pre-replicative complex assembly involved in nuclear cell cycle DNA replication
B	0006270	biological_process	DNA replication initiation
B	0030466	biological_process	silent mating-type cassette heterochromatin formation
B	0031261	cellular_component	DNA replication preinitiation complex
B	0031509	biological_process	subtelomeric heterochromatin formation
C	0003677	molecular_function	DNA binding
C	0003682	molecular_function	chromatin binding
C	0003688	molecular_function	DNA replication origin binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005656	cellular_component	nuclear pre-replicative complex
C	0005664	cellular_component	nuclear origin of replication recognition complex
C	0006260	biological_process	DNA replication
C	0006267	biological_process	pre-replicative complex assembly involved in nuclear cell cycle DNA replication
C	0006270	biological_process	DNA replication initiation
C	0030466	biological_process	silent mating-type cassette heterochromatin formation
C	0031261	cellular_component	DNA replication preinitiation complex
D	0000808	cellular_component	origin recognition complex
D	0003677	molecular_function	DNA binding
D	0003688	molecular_function	DNA replication origin binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005656	cellular_component	nuclear pre-replicative complex
D	0005664	cellular_component	nuclear origin of replication recognition complex
D	0006260	biological_process	DNA replication
D	0006267	biological_process	pre-replicative complex assembly involved in nuclear cell cycle DNA replication
D	0006270	biological_process	DNA replication initiation
D	0030466	biological_process	silent mating-type cassette heterochromatin formation
D	0031261	cellular_component	DNA replication preinitiation complex
E	0000166	molecular_function	nucleotide binding
E	0000808	cellular_component	origin recognition complex
E	0003688	molecular_function	DNA replication origin binding
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005656	cellular_component	nuclear pre-replicative complex
E	0005664	cellular_component	nuclear origin of replication recognition complex
E	0006260	biological_process	DNA replication
E	0006267	biological_process	pre-replicative complex assembly involved in nuclear cell cycle DNA replication
E	0006270	biological_process	DNA replication initiation
E	0006275	biological_process	regulation of DNA replication
E	0030466	biological_process	silent mating-type cassette heterochromatin formation
E	0031261	cellular_component	DNA replication preinitiation complex
E	0035361	cellular_component	Cul8-RING ubiquitin ligase complex
F	0003677	molecular_function	DNA binding
F	0003688	molecular_function	DNA replication origin binding
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005656	cellular_component	nuclear pre-replicative complex
F	0005664	cellular_component	nuclear origin of replication recognition complex
F	0006260	biological_process	DNA replication
F	0006267	biological_process	pre-replicative complex assembly involved in nuclear cell cycle DNA replication
F	0006270	biological_process	DNA replication initiation
F	0030466	biological_process	silent mating-type cassette heterochromatin formation
F	0031261	cellular_component	DNA replication preinitiation complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue AGS 9 2001

Chain	Residue
9	THR82
9	ASP330
9	LYS333
A	SER615
A	ARG616
9	PRO109
9	PRO110
9	GLY111
9	GLY113
9	LYS114
9	THR115
9	ALA116
9	ILE299

site_id	AC2
Number of Residues	16
Details	binding site for residue AGS A 2001

Chain	Residue
A	SER432
A	LEU449
A	PRO481
A	GLY482
A	VAL483
A	GLY484
A	LYS485
A	THR486
A	LEU487
A	GLU567
A	TYR627
A	ILE635
A	ARG639
A	ALA703
A	ARG704
D	ARG267

site_id	AC3
Number of Residues	12
Details	binding site for residue AGS E 2001

Chain	Residue
E	ALA9
E	TYR38
E	SER39
E	GLY40
E	THR41
E	GLY42
E	LYS43
E	THR44
E	TYR45
E	TYR192
E	ILE200
E	PHE256

site_id	AC4
Number of Residues	12
Details	binding site for residue AGS D 2001

Chain	Residue
D	ARG104
D	GLN105
D	SER106
D	TYR107
D	LYS108
D	THR109
D	TYR110
D	ASP217
D	GLU218
D	LYS338
E	LYS151
E	LYS158

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DLNQSKKMNvsEF

Chain	Residue	Details
C	ASP3-PHE15

site_id	PS00847
Number of Residues	9
Details	MCM_1 MCM family signature. GICCIDEFD

Chain	Residue	Details
7	GLY519-ASP527
3	GLY458-ASP466

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	14
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q13415","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)