6WF3
Crystal structure of human Naa50 in complex with a cofactor derived inhibitor (compound 1)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004596 | molecular_function | peptide alpha-N-acetyltransferase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005730 | cellular_component | nucleolus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006338 | biological_process | chromatin remodeling |
| A | 0006474 | biological_process | N-terminal protein amino acid acetylation |
| A | 0007064 | biological_process | mitotic sister chromatid cohesion |
| A | 0010485 | molecular_function | histone H4 acetyltransferase activity |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| A | 0031415 | cellular_component | NatA complex |
| A | 0034087 | biological_process | establishment of mitotic sister chromatid cohesion |
| A | 0052858 | molecular_function | peptidyl-lysine acetyltransferase activity |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0071962 | biological_process | mitotic sister chromatid cohesion, centromeric |
| B | 0004596 | molecular_function | peptide alpha-N-acetyltransferase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005730 | cellular_component | nucleolus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006338 | biological_process | chromatin remodeling |
| B | 0006474 | biological_process | N-terminal protein amino acid acetylation |
| B | 0007064 | biological_process | mitotic sister chromatid cohesion |
| B | 0010485 | molecular_function | histone H4 acetyltransferase activity |
| B | 0016746 | molecular_function | acyltransferase activity |
| B | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| B | 0031415 | cellular_component | NatA complex |
| B | 0034087 | biological_process | establishment of mitotic sister chromatid cohesion |
| B | 0052858 | molecular_function | peptidyl-lysine acetyltransferase activity |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0071962 | biological_process | mitotic sister chromatid cohesion, centromeric |
| C | 0004596 | molecular_function | peptide alpha-N-acetyltransferase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005634 | cellular_component | nucleus |
| C | 0005730 | cellular_component | nucleolus |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006338 | biological_process | chromatin remodeling |
| C | 0006474 | biological_process | N-terminal protein amino acid acetylation |
| C | 0007064 | biological_process | mitotic sister chromatid cohesion |
| C | 0010485 | molecular_function | histone H4 acetyltransferase activity |
| C | 0016746 | molecular_function | acyltransferase activity |
| C | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| C | 0031415 | cellular_component | NatA complex |
| C | 0034087 | biological_process | establishment of mitotic sister chromatid cohesion |
| C | 0052858 | molecular_function | peptidyl-lysine acetyltransferase activity |
| C | 0070062 | cellular_component | extracellular exosome |
| C | 0071962 | biological_process | mitotic sister chromatid cohesion, centromeric |
| D | 0004596 | molecular_function | peptide alpha-N-acetyltransferase activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005634 | cellular_component | nucleus |
| D | 0005730 | cellular_component | nucleolus |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006338 | biological_process | chromatin remodeling |
| D | 0006474 | biological_process | N-terminal protein amino acid acetylation |
| D | 0007064 | biological_process | mitotic sister chromatid cohesion |
| D | 0010485 | molecular_function | histone H4 acetyltransferase activity |
| D | 0016746 | molecular_function | acyltransferase activity |
| D | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| D | 0031415 | cellular_component | NatA complex |
| D | 0034087 | biological_process | establishment of mitotic sister chromatid cohesion |
| D | 0052858 | molecular_function | peptidyl-lysine acetyltransferase activity |
| D | 0070062 | cellular_component | extracellular exosome |
| D | 0071962 | biological_process | mitotic sister chromatid cohesion, centromeric |
| E | 0004596 | molecular_function | peptide alpha-N-acetyltransferase activity |
| E | 0005515 | molecular_function | protein binding |
| E | 0005634 | cellular_component | nucleus |
| E | 0005730 | cellular_component | nucleolus |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0005829 | cellular_component | cytosol |
| E | 0006338 | biological_process | chromatin remodeling |
| E | 0006474 | biological_process | N-terminal protein amino acid acetylation |
| E | 0007064 | biological_process | mitotic sister chromatid cohesion |
| E | 0010485 | molecular_function | histone H4 acetyltransferase activity |
| E | 0016746 | molecular_function | acyltransferase activity |
| E | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| E | 0031415 | cellular_component | NatA complex |
| E | 0034087 | biological_process | establishment of mitotic sister chromatid cohesion |
| E | 0052858 | molecular_function | peptidyl-lysine acetyltransferase activity |
| E | 0070062 | cellular_component | extracellular exosome |
| E | 0071962 | biological_process | mitotic sister chromatid cohesion, centromeric |
| F | 0004596 | molecular_function | peptide alpha-N-acetyltransferase activity |
| F | 0005515 | molecular_function | protein binding |
| F | 0005634 | cellular_component | nucleus |
| F | 0005730 | cellular_component | nucleolus |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0005829 | cellular_component | cytosol |
| F | 0006338 | biological_process | chromatin remodeling |
| F | 0006474 | biological_process | N-terminal protein amino acid acetylation |
| F | 0007064 | biological_process | mitotic sister chromatid cohesion |
| F | 0010485 | molecular_function | histone H4 acetyltransferase activity |
| F | 0016746 | molecular_function | acyltransferase activity |
| F | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| F | 0031415 | cellular_component | NatA complex |
| F | 0034087 | biological_process | establishment of mitotic sister chromatid cohesion |
| F | 0052858 | molecular_function | peptidyl-lysine acetyltransferase activity |
| F | 0070062 | cellular_component | extracellular exosome |
| F | 0071962 | biological_process | mitotic sister chromatid cohesion, centromeric |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | binding site for Di-peptide ACE G 1 and MET G 2 |
| Chain | Residue |
| A | PHE27 |
| A | TYR139 |
| A | HOH210 |
| G | LEU3 |
| G | GLY4 |
| G | COA101 |
| A | PRO28 |
| A | VAL29 |
| A | TYR31 |
| A | ILE74 |
| A | MET75 |
| A | THR76 |
| A | LEU77 |
| A | HIS112 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for Di-peptide PRO G 5 and NH2 G 6 |
| Chain | Residue |
| A | SER30 |
| G | LEU3 |
| G | GLY4 |
| site_id | AC3 |
| Number of Residues | 27 |
| Details | binding site for residues COA G 101 and ACE G 1 |
| Chain | Residue |
| A | ILE26 |
| A | PHE27 |
| A | ILE74 |
| A | MET75 |
| A | THR76 |
| A | LEU77 |
| A | GLY78 |
| A | CYS79 |
| A | ARG84 |
| A | ARG85 |
| A | LEU86 |
| A | GLY87 |
| A | ILE88 |
| A | GLY89 |
| A | THR90 |
| A | VAL113 |
| A | ASN117 |
| A | SER119 |
| A | ASP122 |
| A | PHE123 |
| A | TYR124 |
| A | LYS126 |
| A | HOH201 |
| G | MET2 |
| G | HOH201 |
| G | HOH202 |
| G | HOH203 |
| site_id | AC4 |
| Number of Residues | 14 |
| Details | binding site for Di-peptide ACE O 1 and MET O 2 |
| Chain | Residue |
| B | PHE27 |
| B | PRO28 |
| B | VAL29 |
| B | TYR31 |
| B | MET75 |
| B | THR76 |
| B | LEU77 |
| B | HIS112 |
| B | GLN114 |
| B | TYR139 |
| B | HOH205 |
| H | LEU3 |
| H | GLY4 |
| H | COA101 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for Di-peptide PRO O 5 and NH2 O 6 |
| Chain | Residue |
| B | SER30 |
| H | LEU3 |
| H | GLY4 |
| site_id | AC6 |
| Number of Residues | 28 |
| Details | binding site for residues COA O 101 and ACE O 1 |
| Chain | Residue |
| B | ILE26 |
| B | PHE27 |
| B | MET75 |
| B | THR76 |
| B | LEU77 |
| B | GLY78 |
| B | CYS79 |
| B | ARG84 |
| B | ARG85 |
| B | LEU86 |
| B | GLY87 |
| B | ILE88 |
| B | GLY89 |
| B | THR90 |
| B | VAL113 |
| B | ASN117 |
| B | SER119 |
| B | ALA120 |
| B | ASP122 |
| B | PHE123 |
| B | TYR124 |
| B | LYS126 |
| B | HOH201 |
| H | MET2 |
| H | HOH201 |
| H | HOH202 |
| H | HOH203 |
| H | HOH204 |
| site_id | AC7 |
| Number of Residues | 13 |
| Details | binding site for Di-peptide ACE P 1 and MET P 2 |
| Chain | Residue |
| I | LEU3 |
| I | GLY4 |
| I | COA101 |
| C | PHE27 |
| C | PRO28 |
| C | TYR31 |
| C | ILE74 |
| C | MET75 |
| C | THR76 |
| C | LEU77 |
| C | HIS112 |
| C | TYR139 |
| C | HOH216 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for Di-peptide PRO P 5 and NH2 P 6 |
| Chain | Residue |
| C | SER30 |
| I | LEU3 |
| I | GLY4 |
| site_id | AC9 |
| Number of Residues | 29 |
| Details | binding site for residues COA P 101 and ACE P 1 |
| Chain | Residue |
| C | ILE26 |
| C | PHE27 |
| C | ILE74 |
| C | MET75 |
| C | THR76 |
| C | LEU77 |
| C | GLY78 |
| C | CYS79 |
| C | ARG84 |
| C | ARG85 |
| C | LEU86 |
| C | GLY87 |
| C | GLY89 |
| C | THR90 |
| C | ASN117 |
| C | SER119 |
| C | ALA120 |
| C | ASP122 |
| C | PHE123 |
| C | TYR124 |
| C | LYS126 |
| C | HOH202 |
| I | MET2 |
| I | HOH201 |
| I | HOH202 |
| I | HOH203 |
| I | HOH204 |
| I | HOH205 |
| I | HOH206 |
| site_id | AD1 |
| Number of Residues | 14 |
| Details | binding site for Di-peptide ACE Q 1 and MET Q 2 |
| Chain | Residue |
| D | PHE27 |
| D | PRO28 |
| D | VAL29 |
| D | TYR31 |
| D | MET75 |
| D | THR76 |
| D | LEU77 |
| D | HIS112 |
| D | GLN114 |
| D | TYR139 |
| D | HOH218 |
| J | LEU3 |
| J | GLY4 |
| J | COA101 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for Di-peptide PRO Q 5 and NH2 Q 6 |
| Chain | Residue |
| D | HOH250 |
| J | LEU3 |
| J | GLY4 |
| J | HOH205 |
| J | HOH206 |
| site_id | AD3 |
| Number of Residues | 28 |
| Details | binding site for residues COA Q 101 and ACE Q 1 |
| Chain | Residue |
| D | ILE26 |
| D | PHE27 |
| D | MET75 |
| D | THR76 |
| D | LEU77 |
| D | GLY78 |
| D | CYS79 |
| D | ARG84 |
| D | ARG85 |
| D | LEU86 |
| D | GLY87 |
| D | ILE88 |
| D | GLY89 |
| D | THR90 |
| D | HIS112 |
| D | ASN117 |
| D | SER119 |
| D | ASP122 |
| D | PHE123 |
| D | TYR124 |
| D | LYS126 |
| D | HOH203 |
| J | MET2 |
| J | HOH201 |
| J | HOH202 |
| J | HOH203 |
| J | HOH204 |
| J | HOH207 |
| site_id | AD4 |
| Number of Residues | 12 |
| Details | binding site for Di-peptide ACE R 1 and MET R 2 |
| Chain | Residue |
| E | PHE27 |
| E | PRO28 |
| E | TYR31 |
| E | ILE74 |
| E | MET75 |
| E | THR76 |
| E | LEU77 |
| E | HIS112 |
| E | TYR139 |
| K | LEU3 |
| K | GLY4 |
| K | COA101 |
| site_id | AD5 |
| Number of Residues | 3 |
| Details | binding site for Di-peptide PRO R 5 and NH2 R 6 |
| Chain | Residue |
| E | SER30 |
| K | LEU3 |
| K | GLY4 |
| site_id | AD6 |
| Number of Residues | 28 |
| Details | binding site for residues COA R 101 and ACE R 1 |
| Chain | Residue |
| E | ILE26 |
| E | PHE27 |
| E | ILE74 |
| E | MET75 |
| E | THR76 |
| E | LEU77 |
| E | GLY78 |
| E | CYS79 |
| E | ARG84 |
| E | ARG85 |
| E | LEU86 |
| E | GLY87 |
| E | ILE88 |
| E | GLY89 |
| E | THR90 |
| E | HIS112 |
| E | VAL113 |
| E | ASN117 |
| E | SER119 |
| E | ALA120 |
| E | ASP122 |
| E | PHE123 |
| E | TYR124 |
| E | LYS126 |
| K | MET2 |
| K | HOH201 |
| K | HOH202 |
| K | HOH203 |
| site_id | AD7 |
| Number of Residues | 11 |
| Details | binding site for Di-peptide ACE S 1 and MET S 2 |
| Chain | Residue |
| F | PHE27 |
| F | PRO28 |
| F | TYR31 |
| F | MET75 |
| F | THR76 |
| F | LEU77 |
| F | HIS112 |
| F | TYR139 |
| F | HOH204 |
| L | LEU3 |
| L | COA101 |
| site_id | AD8 |
| Number of Residues | 3 |
| Details | binding site for Di-peptide PRO S 5 and NH2 S 6 |
| Chain | Residue |
| F | SER30 |
| L | LEU3 |
| L | GLY4 |
| site_id | AD9 |
| Number of Residues | 26 |
| Details | binding site for residues COA S 101 and ACE S 1 |
| Chain | Residue |
| F | ILE26 |
| F | PHE27 |
| F | MET75 |
| F | THR76 |
| F | LEU77 |
| F | GLY78 |
| F | CYS79 |
| F | ARG84 |
| F | ARG85 |
| F | LEU86 |
| F | GLY87 |
| F | ILE88 |
| F | GLY89 |
| F | THR90 |
| F | ASN117 |
| F | SER119 |
| F | ALA120 |
| F | ASP122 |
| F | PHE123 |
| F | TYR124 |
| F | LYS126 |
| F | HOH201 |
| L | MET2 |
| L | HOH201 |
| L | HOH202 |
| L | HOH203 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | ACT_SITE: ACT_SITE => ECO:0000269|PubMed:21900231 |
| Chain | Residue | Details |
| B | TYR73 | |
| B | HIS112 | |
| C | TYR73 | |
| C | HIS112 | |
| D | TYR73 | |
| D | HIS112 | |
| E | TYR73 | |
| E | HIS112 | |
| F | TYR73 | |
| F | HIS112 | |
| A | TYR73 | |
| A | HIS112 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 18 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21900231, ECO:0000269|PubMed:27484799, ECO:0007744|PDB:3TFY, ECO:0007744|PDB:4X5K |
| Chain | Residue | Details |
| E | TYR31 | |
| E | MET75 | |
| E | TYR138 | |
| F | TYR31 | |
| F | MET75 | |
| F | TYR138 | |
| A | TYR138 | |
| B | TYR31 | |
| B | MET75 | |
| B | TYR138 | |
| C | TYR31 | |
| C | MET75 | |
| C | TYR138 | |
| D | TYR31 | |
| D | MET75 | |
| D | TYR138 | |
| A | TYR31 | |
| A | MET75 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21900231, ECO:0000269|PubMed:27484799, ECO:0000269|Ref.19, ECO:0007744|PDB:2PSW, ECO:0007744|PDB:3TFY, ECO:0007744|PDB:4X5K |
| Chain | Residue | Details |
| D | LEU77 | |
| D | ASN117 | |
| E | LEU77 | |
| E | ASN117 | |
| F | LEU77 | |
| F | ASN117 | |
| A | ASN117 | |
| B | LEU77 | |
| B | ASN117 | |
| C | LEU77 | |
| C | ASN117 | |
| A | LEU77 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| D | THR12 | |
| E | THR12 | |
| F | THR12 | |
| A | THR12 | |
| B | THR12 | |
| C | THR12 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 12 |
| Details | MOD_RES: N6-acetyllysine; by autocatalysis => ECO:0000269|PubMed:19744929, ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| D | LYS34 | |
| D | LYS37 | |
| E | LYS34 | |
| E | LYS37 | |
| F | LYS34 | |
| F | LYS37 | |
| A | LYS37 | |
| B | LYS34 | |
| B | LYS37 | |
| C | LYS34 | |
| C | LYS37 | |
| A | LYS34 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 6 |
| Details | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:15592455 |
| Chain | Residue | Details |
| A | TYR110 | |
| B | TYR110 | |
| C | TYR110 | |
| D | TYR110 | |
| E | TYR110 | |
| F | TYR110 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 6 |
| Details | MOD_RES: N6-acetyllysine; by autocatalysis => ECO:0000269|PubMed:19744929 |
| Chain | Residue | Details |
| A | LYS140 | |
| B | LYS140 | |
| C | LYS140 | |
| D | LYS140 | |
| E | LYS140 | |
| F | LYS140 |
