6WF2
Crystal structure of mouse SCD1 with a diiron center
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004768 | molecular_function | stearoyl-CoA 9-desaturase activity |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0005730 | cellular_component | nucleolus |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006631 | biological_process | fatty acid metabolic process |
| A | 0006633 | biological_process | fatty acid biosynthetic process |
| A | 0006636 | biological_process | unsaturated fatty acid biosynthetic process |
| A | 0006641 | biological_process | triglyceride metabolic process |
| A | 0007584 | biological_process | response to nutrient |
| A | 0008610 | biological_process | lipid biosynthetic process |
| A | 0009617 | biological_process | response to bacterium |
| A | 0016020 | cellular_component | membrane |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016717 | molecular_function | oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water |
| A | 0032896 | molecular_function | palmitoyl-CoA 9-desaturase activity |
| A | 0042632 | biological_process | cholesterol homeostasis |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0048733 | biological_process | sebaceous gland development |
| A | 0050830 | biological_process | defense response to Gram-positive bacterium |
| A | 0050872 | biological_process | white fat cell differentiation |
| A | 0050873 | biological_process | brown fat cell differentiation |
| A | 0055088 | biological_process | lipid homeostasis |
| A | 0055092 | biological_process | sterol homeostasis |
| A | 0070542 | biological_process | response to fatty acid |
| A | 0120162 | biological_process | positive regulation of cold-induced thermogenesis |
| A | 1903699 | biological_process | tarsal gland development |
| A | 1903966 | biological_process | monounsaturated fatty acid biosynthetic process |
| B | 0004768 | molecular_function | stearoyl-CoA 9-desaturase activity |
| B | 0005506 | molecular_function | iron ion binding |
| B | 0005730 | cellular_component | nucleolus |
| B | 0005783 | cellular_component | endoplasmic reticulum |
| B | 0005789 | cellular_component | endoplasmic reticulum membrane |
| B | 0006629 | biological_process | lipid metabolic process |
| B | 0006631 | biological_process | fatty acid metabolic process |
| B | 0006633 | biological_process | fatty acid biosynthetic process |
| B | 0006636 | biological_process | unsaturated fatty acid biosynthetic process |
| B | 0006641 | biological_process | triglyceride metabolic process |
| B | 0007584 | biological_process | response to nutrient |
| B | 0008610 | biological_process | lipid biosynthetic process |
| B | 0009617 | biological_process | response to bacterium |
| B | 0016020 | cellular_component | membrane |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016717 | molecular_function | oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water |
| B | 0032896 | molecular_function | palmitoyl-CoA 9-desaturase activity |
| B | 0042632 | biological_process | cholesterol homeostasis |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0048733 | biological_process | sebaceous gland development |
| B | 0050830 | biological_process | defense response to Gram-positive bacterium |
| B | 0050872 | biological_process | white fat cell differentiation |
| B | 0050873 | biological_process | brown fat cell differentiation |
| B | 0055088 | biological_process | lipid homeostasis |
| B | 0055092 | biological_process | sterol homeostasis |
| B | 0070542 | biological_process | response to fatty acid |
| B | 0120162 | biological_process | positive regulation of cold-induced thermogenesis |
| B | 1903699 | biological_process | tarsal gland development |
| B | 1903966 | biological_process | monounsaturated fatty acid biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue FE A 401 |
| Chain | Residue |
| A | HIS116 |
| A | HIS121 |
| A | HIS153 |
| A | HIS157 |
| A | HIS297 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue FE A 402 |
| Chain | Residue |
| A | HIS156 |
| A | HIS265 |
| A | HIS294 |
| A | HIS298 |
| site_id | AC3 |
| Number of Residues | 25 |
| Details | binding site for residue 3VV A 403 |
| Chain | Residue |
| A | ASN71 |
| A | ILE111 |
| A | PHE142 |
| A | GLN143 |
| A | ASN144 |
| A | TRP149 |
| A | ARG151 |
| A | ASP152 |
| A | HIS153 |
| A | TRP180 |
| A | LEU181 |
| A | VAL183 |
| A | ARG184 |
| A | LYS185 |
| A | VAL189 |
| A | LYS190 |
| A | GLY193 |
| A | GLY194 |
| A | TYR250 |
| A | LEU254 |
| A | THR257 |
| A | TRP258 |
| A | VAL260 |
| A | ASN261 |
| A | ALA288 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue FE B 401 |
| Chain | Residue |
| B | HIS116 |
| B | HIS121 |
| B | HIS153 |
| B | HIS157 |
| B | HIS297 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue FE B 402 |
| Chain | Residue |
| B | HIS156 |
| B | HIS265 |
| B | HIS294 |
| B | HIS298 |
| site_id | AC6 |
| Number of Residues | 30 |
| Details | binding site for residue 3VV B 403 |
| Chain | Residue |
| B | ASN71 |
| B | ALA108 |
| B | ILE111 |
| B | THR112 |
| B | HIS116 |
| B | PHE142 |
| B | GLN143 |
| B | ASN144 |
| B | GLU148 |
| B | TRP149 |
| B | ARG151 |
| B | ASP152 |
| B | HIS153 |
| B | TRP180 |
| B | LEU181 |
| B | VAL183 |
| B | ARG184 |
| B | LYS185 |
| B | VAL189 |
| B | LYS190 |
| B | GLY193 |
| B | GLY194 |
| B | TYR250 |
| B | THR257 |
| B | TRP258 |
| B | VAL260 |
| B | ASN261 |
| B | GLY287 |
| B | ALA288 |
| B | GLU291 |
Functional Information from PROSITE/UniProt
| site_id | PS00476 |
| Number of Residues | 15 |
| Details | FATTY_ACID_DESATUR_1 Fatty acid desaturases family 1 signature. GEgFHNYHHtFPfDY |
| Chain | Residue | Details |
| A | GLY290-TYR304 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 160 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"26098370","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | Topological domain: {"description":"Lumenal","evidences":[{"source":"PubMed","id":"26098370","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 196 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"26098370","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 95 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"16275639","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 10 |
| Details | Motif: {"description":"Histidine box-1","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | Motif: {"description":"Histidine box-2","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 8 |
| Details | Motif: {"description":"Histidine box-3","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26098370","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26098370","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
