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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6WEV

Crystal structures of human E-NPP 1: bound to N-{[1-(6,7-dimethoxy-5,8-dihydroquinazolin-4-yl)piperidin-4-yl]methyl}sulfuric diamide

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
AbA0003676molecular_functionnucleic acid binding
AbA0004115molecular_function3',5'-cyclic-AMP phosphodiesterase activity
AbA0004527molecular_functionexonuclease activity
AbA0004528molecular_functionphosphodiesterase I activity
AbA0004551molecular_functiondinucleotide phosphatase activity
AbA0005044molecular_functionscavenger receptor activity
AbA0005158molecular_functioninsulin receptor binding
AbA0005509molecular_functioncalcium ion binding
AbA0005515molecular_functionprotein binding
AbA0005524molecular_functionATP binding
AbA0005576cellular_componentextracellular region
AbA0005615cellular_componentextracellular space
AbA0005765cellular_componentlysosomal membrane
AbA0005886cellular_componentplasma membrane
AbA0006091biological_processgeneration of precursor metabolites and energy
AbA0006796biological_processphosphate-containing compound metabolic process
AbA0006955biological_processimmune response
AbA0008270molecular_functionzinc ion binding
AbA0009143biological_processnucleoside triphosphate catabolic process
AbA0009986cellular_componentcell surface
AbA0010035biological_processobsolete response to inorganic substance
AbA0010467biological_processgene expression
AbA0016020cellular_componentmembrane
AbA0016192biological_processvesicle-mediated transport
AbA0016323cellular_componentbasolateral plasma membrane
AbA0016787molecular_functionhydrolase activity
AbA0016791molecular_functionphosphatase activity
AbA0030247molecular_functionpolysaccharide binding
AbA0030282biological_processbone mineralization
AbA0030308biological_processnegative regulation of cell growth
AbA0030318biological_processmelanocyte differentiation
AbA0030500biological_processregulation of bone mineralization
AbA0030502biological_processnegative regulation of bone mineralization
AbA0030505biological_processinorganic diphosphate transport
AbA0030643biological_processintracellular phosphate ion homeostasis
AbA0031214biological_processbiomineral tissue development
AbA0032869biological_processcellular response to insulin stimulus
AbA0033198biological_processresponse to ATP
AbA0036219molecular_functionGTP diphosphatase activity
AbA0036221molecular_functionUTP diphosphatase activity
AbA0042803molecular_functionprotein homodimerization activity
AbA0045599biological_processnegative regulation of fat cell differentiation
AbA0045719biological_processnegative regulation of glycogen biosynthetic process
AbA0046034biological_processATP metabolic process
AbA0046325biological_processnegative regulation of D-glucose import
AbA0046627biological_processnegative regulation of insulin receptor signaling pathway
AbA0046872molecular_functionmetal ion binding
AbA0047429molecular_functionnucleoside triphosphate diphosphatase activity
AbA0047693molecular_functionATP diphosphatase activity
AbA0048513biological_processanimal organ development
AbA0050427biological_process3'-phosphoadenosine 5'-phosphosulfate metabolic process
AbA0050656molecular_function3'-phosphoadenosine 5'-phosphosulfate binding
AbA0055062biological_processphosphate ion homeostasis
AbA0090304biological_processnucleic acid metabolic process
AbA0106177molecular_functioncyclic-GMP-AMP hydrolase activity
AbA0110148biological_processobsolete biomineralization
AbA1990787biological_processnegative regulation of hh target transcription factor activity
BbB0003676molecular_functionnucleic acid binding
BbB0004115molecular_function3',5'-cyclic-AMP phosphodiesterase activity
BbB0004527molecular_functionexonuclease activity
BbB0004528molecular_functionphosphodiesterase I activity
BbB0004551molecular_functiondinucleotide phosphatase activity
BbB0005044molecular_functionscavenger receptor activity
BbB0005158molecular_functioninsulin receptor binding
BbB0005509molecular_functioncalcium ion binding
BbB0005515molecular_functionprotein binding
BbB0005524molecular_functionATP binding
BbB0005576cellular_componentextracellular region
BbB0005615cellular_componentextracellular space
BbB0005765cellular_componentlysosomal membrane
BbB0005886cellular_componentplasma membrane
BbB0006091biological_processgeneration of precursor metabolites and energy
BbB0006796biological_processphosphate-containing compound metabolic process
BbB0006955biological_processimmune response
BbB0008270molecular_functionzinc ion binding
BbB0009143biological_processnucleoside triphosphate catabolic process
BbB0009986cellular_componentcell surface
BbB0010035biological_processobsolete response to inorganic substance
BbB0010467biological_processgene expression
BbB0016020cellular_componentmembrane
BbB0016192biological_processvesicle-mediated transport
BbB0016323cellular_componentbasolateral plasma membrane
BbB0016787molecular_functionhydrolase activity
BbB0016791molecular_functionphosphatase activity
BbB0030247molecular_functionpolysaccharide binding
BbB0030282biological_processbone mineralization
BbB0030308biological_processnegative regulation of cell growth
BbB0030318biological_processmelanocyte differentiation
BbB0030500biological_processregulation of bone mineralization
BbB0030502biological_processnegative regulation of bone mineralization
BbB0030505biological_processinorganic diphosphate transport
BbB0030643biological_processintracellular phosphate ion homeostasis
BbB0031214biological_processbiomineral tissue development
BbB0032869biological_processcellular response to insulin stimulus
BbB0033198biological_processresponse to ATP
BbB0036219molecular_functionGTP diphosphatase activity
BbB0036221molecular_functionUTP diphosphatase activity
BbB0042803molecular_functionprotein homodimerization activity
BbB0045599biological_processnegative regulation of fat cell differentiation
BbB0045719biological_processnegative regulation of glycogen biosynthetic process
BbB0046034biological_processATP metabolic process
BbB0046325biological_processnegative regulation of D-glucose import
BbB0046627biological_processnegative regulation of insulin receptor signaling pathway
BbB0046872molecular_functionmetal ion binding
BbB0047429molecular_functionnucleoside triphosphate diphosphatase activity
BbB0047693molecular_functionATP diphosphatase activity
BbB0048513biological_processanimal organ development
BbB0050427biological_process3'-phosphoadenosine 5'-phosphosulfate metabolic process
BbB0050656molecular_function3'-phosphoadenosine 5'-phosphosulfate binding
BbB0055062biological_processphosphate ion homeostasis
BbB0090304biological_processnucleic acid metabolic process
BbB0106177molecular_functioncyclic-GMP-AMP hydrolase activity
BbB0110148biological_processobsolete biomineralization
BbB1990787biological_processnegative regulation of hh target transcription factor activity
Functional Information from PROSITE/UniProt
site_idPS00524
Number of Residues21
DetailsSMB_1 Somatomedin B domain (SMB) signature. CrCdaaCvelgn.CClDYqetC
ChainResidueDetails
AbACYS120-CYS140
AbACYS164-CYS184
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues88
DetailsDomain: {"description":"SMB 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00350","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues800
DetailsRegion: {"description":"Phosphodiesterase","evidences":[{"source":"UniProtKB","id":"P06802","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues50
DetailsRegion: {"description":"Linker","evidences":[{"source":"UniProtKB","id":"P06802","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues2
DetailsActive site: {"description":"AMP-threonine intermediate","evidences":[{"source":"UniProtKB","id":"P06802","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues34
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P06802","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues2
DetailsSite: {"description":"Essential for catalytic activity","evidences":[{"source":"UniProtKB","id":"Q9R1E6","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q924C3","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues12
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues40
DetailsDomain: {"description":"SMB 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00350","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

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PDB entries from 2025-12-24

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