6WEU

Crystal structures of human E-NPP 1: bound to adenosine-5'-thio-monophosphate

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
AbA	0003676	molecular_function	nucleic acid binding
AbA	0004115	molecular_function	3',5'-cyclic-AMP phosphodiesterase activity
AbA	0004527	molecular_function	exonuclease activity
AbA	0004528	molecular_function	phosphodiesterase I activity
AbA	0004551	molecular_function	dinucleotide phosphatase activity
AbA	0005044	molecular_function	scavenger receptor activity
AbA	0005158	molecular_function	insulin receptor binding
AbA	0005509	molecular_function	calcium ion binding
AbA	0005515	molecular_function	protein binding
AbA	0005524	molecular_function	ATP binding
AbA	0005576	cellular_component	extracellular region
AbA	0005615	cellular_component	extracellular space
AbA	0005765	cellular_component	lysosomal membrane
AbA	0005886	cellular_component	plasma membrane
AbA	0006091	biological_process	generation of precursor metabolites and energy
AbA	0006796	biological_process	phosphate-containing compound metabolic process
AbA	0006955	biological_process	immune response
AbA	0008270	molecular_function	zinc ion binding
AbA	0009143	biological_process	nucleoside triphosphate catabolic process
AbA	0009986	cellular_component	cell surface
AbA	0010035	biological_process	obsolete response to inorganic substance
AbA	0010467	biological_process	gene expression
AbA	0016020	cellular_component	membrane
AbA	0016192	biological_process	vesicle-mediated transport
AbA	0016323	cellular_component	basolateral plasma membrane
AbA	0016787	molecular_function	hydrolase activity
AbA	0016788	molecular_function	hydrolase activity, acting on ester bonds
AbA	0016791	molecular_function	phosphatase activity
AbA	0030247	molecular_function	polysaccharide binding
AbA	0030282	biological_process	bone mineralization
AbA	0030308	biological_process	negative regulation of cell growth
AbA	0030318	biological_process	melanocyte differentiation
AbA	0030500	biological_process	regulation of bone mineralization
AbA	0030502	biological_process	negative regulation of bone mineralization
AbA	0030505	biological_process	inorganic diphosphate transport
AbA	0030643	biological_process	intracellular phosphate ion homeostasis
AbA	0030730	biological_process	sequestering of triglyceride
AbA	0031214	biological_process	biomineral tissue development
AbA	0031953	biological_process	negative regulation of protein autophosphorylation
AbA	0032869	biological_process	cellular response to insulin stimulus
AbA	0033198	biological_process	response to ATP
AbA	0036219	molecular_function	GTP diphosphatase activity
AbA	0036221	molecular_function	UTP diphosphatase activity
AbA	0042803	molecular_function	protein homodimerization activity
AbA	0045599	biological_process	negative regulation of fat cell differentiation
AbA	0045719	biological_process	negative regulation of glycogen biosynthetic process
AbA	0046034	biological_process	ATP metabolic process
AbA	0046325	biological_process	negative regulation of glucose import
AbA	0046627	biological_process	negative regulation of insulin receptor signaling pathway
AbA	0046872	molecular_function	metal ion binding
AbA	0047429	molecular_function	nucleoside triphosphate diphosphatase activity
AbA	0047693	molecular_function	ATP diphosphatase activity
AbA	0050427	biological_process	3'-phosphoadenosine 5'-phosphosulfate metabolic process
AbA	0050656	molecular_function	3'-phosphoadenosine 5'-phosphosulfate binding
AbA	0055062	biological_process	phosphate ion homeostasis
AbA	0090304	biological_process	nucleic acid metabolic process
AbA	0106177	molecular_function	cyclic-GMP-AMP hydrolase activity
AbA	0110148	biological_process	obsolete biomineralization
AbA	1990787	biological_process	negative regulation of hh target transcription factor activity
BbB	0003676	molecular_function	nucleic acid binding
BbB	0004115	molecular_function	3',5'-cyclic-AMP phosphodiesterase activity
BbB	0004527	molecular_function	exonuclease activity
BbB	0004528	molecular_function	phosphodiesterase I activity
BbB	0004551	molecular_function	dinucleotide phosphatase activity
BbB	0005044	molecular_function	scavenger receptor activity
BbB	0005158	molecular_function	insulin receptor binding
BbB	0005509	molecular_function	calcium ion binding
BbB	0005515	molecular_function	protein binding
BbB	0005524	molecular_function	ATP binding
BbB	0005576	cellular_component	extracellular region
BbB	0005615	cellular_component	extracellular space
BbB	0005765	cellular_component	lysosomal membrane
BbB	0005886	cellular_component	plasma membrane
BbB	0006091	biological_process	generation of precursor metabolites and energy
BbB	0006796	biological_process	phosphate-containing compound metabolic process
BbB	0006955	biological_process	immune response
BbB	0008270	molecular_function	zinc ion binding
BbB	0009143	biological_process	nucleoside triphosphate catabolic process
BbB	0009986	cellular_component	cell surface
BbB	0010035	biological_process	obsolete response to inorganic substance
BbB	0010467	biological_process	gene expression
BbB	0016020	cellular_component	membrane
BbB	0016192	biological_process	vesicle-mediated transport
BbB	0016323	cellular_component	basolateral plasma membrane
BbB	0016787	molecular_function	hydrolase activity
BbB	0016788	molecular_function	hydrolase activity, acting on ester bonds
BbB	0016791	molecular_function	phosphatase activity
BbB	0030247	molecular_function	polysaccharide binding
BbB	0030282	biological_process	bone mineralization
BbB	0030308	biological_process	negative regulation of cell growth
BbB	0030318	biological_process	melanocyte differentiation
BbB	0030500	biological_process	regulation of bone mineralization
BbB	0030502	biological_process	negative regulation of bone mineralization
BbB	0030505	biological_process	inorganic diphosphate transport
BbB	0030643	biological_process	intracellular phosphate ion homeostasis
BbB	0030730	biological_process	sequestering of triglyceride
BbB	0031214	biological_process	biomineral tissue development
BbB	0031953	biological_process	negative regulation of protein autophosphorylation
BbB	0032869	biological_process	cellular response to insulin stimulus
BbB	0033198	biological_process	response to ATP
BbB	0036219	molecular_function	GTP diphosphatase activity
BbB	0036221	molecular_function	UTP diphosphatase activity
BbB	0042803	molecular_function	protein homodimerization activity
BbB	0045599	biological_process	negative regulation of fat cell differentiation
BbB	0045719	biological_process	negative regulation of glycogen biosynthetic process
BbB	0046034	biological_process	ATP metabolic process
BbB	0046325	biological_process	negative regulation of glucose import
BbB	0046627	biological_process	negative regulation of insulin receptor signaling pathway
BbB	0046872	molecular_function	metal ion binding
BbB	0047429	molecular_function	nucleoside triphosphate diphosphatase activity
BbB	0047693	molecular_function	ATP diphosphatase activity
BbB	0050427	biological_process	3'-phosphoadenosine 5'-phosphosulfate metabolic process
BbB	0050656	molecular_function	3'-phosphoadenosine 5'-phosphosulfate binding
BbB	0055062	biological_process	phosphate ion homeostasis
BbB	0090304	biological_process	nucleic acid metabolic process
BbB	0106177	molecular_function	cyclic-GMP-AMP hydrolase activity
BbB	0110148	biological_process	obsolete biomineralization
BbB	1990787	biological_process	negative regulation of hh target transcription factor activity

Functional Information from PROSITE/UniProt

site_id	PS00524
Number of Residues	21
Details	SMB_1 Somatomedin B domain (SMB) signature. CrCdaaCvelgn.CClDYqetC

Chain	Residue	Details
AbA	CYS120-CYS140
AbA	CYS164-CYS184

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	150
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
AbA	MET1-LYS76
BbB	MET1-LYS76

---

site_id	SWS_FT_FI2
Number of Residues	40
Details	TRANSMEM: Helical; Signal-anchor for type II membrane protein => ECO:0000255

Chain	Residue	Details
AbA	VAL77-LEU97
BbB	VAL77-LEU97

---

site_id	SWS_FT_FI3
Number of Residues	1654
Details	TOPO_DOM: Extracellular => ECO:0000255

Chain	Residue	Details
AbA	LYS98-ASP925
BbB	LYS98-ASP925

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	ACT_SITE: AMP-threonine intermediate => ECO:0000250|UniProtKB:P06802

Chain	Residue	Details
AbA	THR256
BbB	THR256

---

site_id	SWS_FT_FI5
Number of Residues	34
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P06802

Chain	Residue	Details
AbA	ASP218
AbA	HIS424
AbA	SER532
AbA	HIS535
AbA	ASP800
AbA	ASP802
AbA	ASP804
AbA	ARG806
AbA	ASP808
BbB	ASP218
BbB	THR256
AbA	THR256
BbB	ASN277
BbB	LEU290
BbB	LYS295
BbB	TYR340
BbB	ASP376
BbB	HIS380
BbB	ASP423
BbB	HIS424
BbB	SER532
BbB	HIS535
AbA	ASN277
BbB	ASP800
BbB	ASP802
BbB	ASP804
BbB	ARG806
BbB	ASP808
AbA	LEU290
AbA	LYS295
AbA	TYR340
AbA	ASP376
AbA	HIS380
AbA	ASP423

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	SITE: Cleavage => ECO:0000250|UniProtKB:P06802

Chain	Residue	Details
AbA	ALA102
BbB	ALA102

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	SITE: Essential for catalytic activity => ECO:0000250|UniProtKB:Q9R1E6

Chain	Residue	Details
AbA	LYS915
BbB	LYS915

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q924C3

Chain	Residue	Details
AbA	THR256
BbB	THR256

---

site_id	SWS_FT_FI9
Number of Residues	12
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
AbA	ASN179
BbB	ASN585
BbB	ASN700
BbB	ASN731
AbA	ASN285
AbA	ASN477
AbA	ASN585
AbA	ASN700
AbA	ASN731
BbB	ASN179
BbB	ASN285
BbB	ASN477

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973

Chain	Residue	Details
AbA	ASN341
BbB	ASN341

---

site_id	SWS_FT_FI11
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19349973

Chain	Residue	Details
AbA	ASN643
AbA	ASN748
BbB	ASN643
BbB	ASN748

---