6WET

Crystal structures of human E-NPP 1: apo

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
AaA	0003676	molecular_function	nucleic acid binding
AaA	0004115	molecular_function	3',5'-cyclic-AMP phosphodiesterase activity
AaA	0004527	molecular_function	exonuclease activity
AaA	0004528	molecular_function	phosphodiesterase I activity
AaA	0004551	molecular_function	dinucleotide phosphatase activity
AaA	0005044	molecular_function	scavenger receptor activity
AaA	0005158	molecular_function	insulin receptor binding
AaA	0005509	molecular_function	calcium ion binding
AaA	0005515	molecular_function	protein binding
AaA	0005524	molecular_function	ATP binding
AaA	0005576	cellular_component	extracellular region
AaA	0005615	cellular_component	extracellular space
AaA	0005765	cellular_component	lysosomal membrane
AaA	0005886	cellular_component	plasma membrane
AaA	0006091	biological_process	generation of precursor metabolites and energy
AaA	0006796	biological_process	phosphate-containing compound metabolic process
AaA	0006955	biological_process	immune response
AaA	0008270	molecular_function	zinc ion binding
AaA	0009143	biological_process	nucleoside triphosphate catabolic process
AaA	0009986	cellular_component	cell surface
AaA	0010035	biological_process	obsolete response to inorganic substance
AaA	0010467	biological_process	gene expression
AaA	0016020	cellular_component	membrane
AaA	0016192	biological_process	vesicle-mediated transport
AaA	0016323	cellular_component	basolateral plasma membrane
AaA	0016787	molecular_function	hydrolase activity
AaA	0016788	molecular_function	hydrolase activity, acting on ester bonds
AaA	0016791	molecular_function	phosphatase activity
AaA	0030247	molecular_function	polysaccharide binding
AaA	0030282	biological_process	bone mineralization
AaA	0030308	biological_process	negative regulation of cell growth
AaA	0030318	biological_process	melanocyte differentiation
AaA	0030500	biological_process	regulation of bone mineralization
AaA	0030502	biological_process	negative regulation of bone mineralization
AaA	0030505	biological_process	inorganic diphosphate transport
AaA	0030643	biological_process	intracellular phosphate ion homeostasis
AaA	0030730	biological_process	sequestering of triglyceride
AaA	0031214	biological_process	biomineral tissue development
AaA	0031953	biological_process	negative regulation of protein autophosphorylation
AaA	0032869	biological_process	cellular response to insulin stimulus
AaA	0033198	biological_process	response to ATP
AaA	0036219	molecular_function	GTP diphosphatase activity
AaA	0036221	molecular_function	UTP diphosphatase activity
AaA	0042803	molecular_function	protein homodimerization activity
AaA	0045599	biological_process	negative regulation of fat cell differentiation
AaA	0045719	biological_process	negative regulation of glycogen biosynthetic process
AaA	0046034	biological_process	ATP metabolic process
AaA	0046325	biological_process	negative regulation of D-glucose import
AaA	0046627	biological_process	negative regulation of insulin receptor signaling pathway
AaA	0046872	molecular_function	metal ion binding
AaA	0047429	molecular_function	nucleoside triphosphate diphosphatase activity
AaA	0047693	molecular_function	ATP diphosphatase activity
AaA	0050427	biological_process	3'-phosphoadenosine 5'-phosphosulfate metabolic process
AaA	0050656	molecular_function	3'-phosphoadenosine 5'-phosphosulfate binding
AaA	0055062	biological_process	phosphate ion homeostasis
AaA	0090304	biological_process	nucleic acid metabolic process
AaA	0106177	molecular_function	cyclic-GMP-AMP hydrolase activity
AaA	0110148	biological_process	obsolete biomineralization
AaA	1990787	biological_process	negative regulation of hh target transcription factor activity
BaB	0003676	molecular_function	nucleic acid binding
BaB	0004115	molecular_function	3',5'-cyclic-AMP phosphodiesterase activity
BaB	0004527	molecular_function	exonuclease activity
BaB	0004528	molecular_function	phosphodiesterase I activity
BaB	0004551	molecular_function	dinucleotide phosphatase activity
BaB	0005044	molecular_function	scavenger receptor activity
BaB	0005158	molecular_function	insulin receptor binding
BaB	0005509	molecular_function	calcium ion binding
BaB	0005515	molecular_function	protein binding
BaB	0005524	molecular_function	ATP binding
BaB	0005576	cellular_component	extracellular region
BaB	0005615	cellular_component	extracellular space
BaB	0005765	cellular_component	lysosomal membrane
BaB	0005886	cellular_component	plasma membrane
BaB	0006091	biological_process	generation of precursor metabolites and energy
BaB	0006796	biological_process	phosphate-containing compound metabolic process
BaB	0006955	biological_process	immune response
BaB	0008270	molecular_function	zinc ion binding
BaB	0009143	biological_process	nucleoside triphosphate catabolic process
BaB	0009986	cellular_component	cell surface
BaB	0010035	biological_process	obsolete response to inorganic substance
BaB	0010467	biological_process	gene expression
BaB	0016020	cellular_component	membrane
BaB	0016192	biological_process	vesicle-mediated transport
BaB	0016323	cellular_component	basolateral plasma membrane
BaB	0016787	molecular_function	hydrolase activity
BaB	0016788	molecular_function	hydrolase activity, acting on ester bonds
BaB	0016791	molecular_function	phosphatase activity
BaB	0030247	molecular_function	polysaccharide binding
BaB	0030282	biological_process	bone mineralization
BaB	0030308	biological_process	negative regulation of cell growth
BaB	0030318	biological_process	melanocyte differentiation
BaB	0030500	biological_process	regulation of bone mineralization
BaB	0030502	biological_process	negative regulation of bone mineralization
BaB	0030505	biological_process	inorganic diphosphate transport
BaB	0030643	biological_process	intracellular phosphate ion homeostasis
BaB	0030730	biological_process	sequestering of triglyceride
BaB	0031214	biological_process	biomineral tissue development
BaB	0031953	biological_process	negative regulation of protein autophosphorylation
BaB	0032869	biological_process	cellular response to insulin stimulus
BaB	0033198	biological_process	response to ATP
BaB	0036219	molecular_function	GTP diphosphatase activity
BaB	0036221	molecular_function	UTP diphosphatase activity
BaB	0042803	molecular_function	protein homodimerization activity
BaB	0045599	biological_process	negative regulation of fat cell differentiation
BaB	0045719	biological_process	negative regulation of glycogen biosynthetic process
BaB	0046034	biological_process	ATP metabolic process
BaB	0046325	biological_process	negative regulation of D-glucose import
BaB	0046627	biological_process	negative regulation of insulin receptor signaling pathway
BaB	0046872	molecular_function	metal ion binding
BaB	0047429	molecular_function	nucleoside triphosphate diphosphatase activity
BaB	0047693	molecular_function	ATP diphosphatase activity
BaB	0050427	biological_process	3'-phosphoadenosine 5'-phosphosulfate metabolic process
BaB	0050656	molecular_function	3'-phosphoadenosine 5'-phosphosulfate binding
BaB	0055062	biological_process	phosphate ion homeostasis
BaB	0090304	biological_process	nucleic acid metabolic process
BaB	0106177	molecular_function	cyclic-GMP-AMP hydrolase activity
BaB	0110148	biological_process	obsolete biomineralization
BaB	1990787	biological_process	negative regulation of hh target transcription factor activity

Functional Information from PROSITE/UniProt

site_id	PS00524
Number of Residues	21
Details	SMB_1 Somatomedin B domain (SMB) signature. CrCdaaCvelgn.CClDYqetC

Chain	Residue	Details
AaA	CYS120-CYS140
AaA	CYS164-CYS184

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	150
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
AaA	MET1-LYS76
BaB	MET1-LYS76

---

site_id	SWS_FT_FI2
Number of Residues	40
Details	TRANSMEM: Helical; Signal-anchor for type II membrane protein => ECO:0000255

Chain	Residue	Details
AaA	VAL77-LEU97
BaB	VAL77-LEU97

---

site_id	SWS_FT_FI3
Number of Residues	1654
Details	TOPO_DOM: Extracellular => ECO:0000255

Chain	Residue	Details
AaA	LYS98-ASP925
BaB	LYS98-ASP925

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	ACT_SITE: AMP-threonine intermediate => ECO:0000250|UniProtKB:P06802

Chain	Residue	Details
AaA	TPO256
BaB	TPO256

---

site_id	SWS_FT_FI5
Number of Residues	34
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P06802

Chain	Residue	Details
AaA	ASP218
AaA	HIS424
AaA	SER532
AaA	HIS535
AaA	ASP800
AaA	ASP802
AaA	ASP804
AaA	ARG806
AaA	ASP808
BaB	ASP218
BaB	TPO256
AaA	TPO256
BaB	ASN277
BaB	LEU290
BaB	LYS295
BaB	TYR340
BaB	ASP376
BaB	HIS380
BaB	ASP423
BaB	HIS424
BaB	SER532
BaB	HIS535
AaA	ASN277
BaB	ASP800
BaB	ASP802
BaB	ASP804
BaB	ARG806
BaB	ASP808
AaA	LEU290
AaA	LYS295
AaA	TYR340
AaA	ASP376
AaA	HIS380
AaA	ASP423

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	SITE: Cleavage => ECO:0000250|UniProtKB:P06802

Chain	Residue	Details
AaA	ALA102
BaB	ALA102

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	SITE: Essential for catalytic activity => ECO:0000250|UniProtKB:Q9R1E6

Chain	Residue	Details
AaA	LYS915
BaB	LYS915

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q924C3

Chain	Residue	Details
AaA	TPO256
BaB	TPO256

---

site_id	SWS_FT_FI9
Number of Residues	12
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
AaA	ASN179
BaB	ASN585
BaB	ASN700
BaB	ASN731
AaA	ASN285
AaA	ASN477
AaA	ASN585
AaA	ASN700
AaA	ASN731
BaB	ASN179
BaB	ASN285
BaB	ASN477

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973

Chain	Residue	Details
AaA	ASN341
BaB	ASN341

---

site_id	SWS_FT_FI11
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19349973

Chain	Residue	Details
AaA	ASN643
AaA	ASN748
BaB	ASN643
BaB	ASN748

---