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6WEK

Structure of cGMP-bound WT TAX-4 reconstituted in lipid nanodiscs

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0003031biological_processdetection of carbon dioxide
A0005216molecular_functionmonoatomic ion channel activity
A0005222molecular_functionintracellularly cAMP-activated cation channel activity
A0005223molecular_functionintracellularly cGMP-activated cation channel activity
A0005249molecular_functionvoltage-gated potassium channel activity
A0005886cellular_componentplasma membrane
A0005929cellular_componentcilium
A0006811biological_processmonoatomic ion transport
A0006813biological_processpotassium ion transport
A0006935biological_processchemotaxis
A0007199biological_processG protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
A0007399biological_processnervous system development
A0007602biological_processphototransduction
A0007635biological_processchemosensory behavior
A0009454biological_processaerotaxis
A0010628biological_processpositive regulation of gene expression
A0010754biological_processnegative regulation of cGMP-mediated signaling
A0016020cellular_componentmembrane
A0017071cellular_componentintracellular cyclic nucleotide activated cation channel complex
A0019722biological_processcalcium-mediated signaling
A0030425cellular_componentdendrite
A0030516biological_processregulation of axon extension
A0030553molecular_functioncGMP binding
A0034220biological_processmonoatomic ion transmembrane transport
A0034703cellular_componentcation channel complex
A0040010biological_processpositive regulation of growth rate
A0040040biological_processthermosensory behavior
A0042048biological_processolfactory behavior
A0042802molecular_functionidentical protein binding
A0042995cellular_componentcell projection
A0043052biological_processthermotaxis
A0044877molecular_functionprotein-containing complex binding
A0045664biological_processregulation of neuron differentiation
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0048609biological_processmulticellular organismal reproductive process
A0048812biological_processneuron projection morphogenesis
A0050907biological_processdetection of chemical stimulus involved in sensory perception
A0055085biological_processtransmembrane transport
A0055093biological_processresponse to hyperoxia
A0070482biological_processresponse to oxygen levels
A0071805biological_processpotassium ion transmembrane transport
A0097543cellular_componentciliary inversin compartment
A0097730cellular_componentnon-motile cilium
A0098655biological_processmonoatomic cation transmembrane transport
B0000166molecular_functionnucleotide binding
B0003031biological_processdetection of carbon dioxide
B0005216molecular_functionmonoatomic ion channel activity
B0005222molecular_functionintracellularly cAMP-activated cation channel activity
B0005223molecular_functionintracellularly cGMP-activated cation channel activity
B0005249molecular_functionvoltage-gated potassium channel activity
B0005886cellular_componentplasma membrane
B0005929cellular_componentcilium
B0006811biological_processmonoatomic ion transport
B0006813biological_processpotassium ion transport
B0006935biological_processchemotaxis
B0007199biological_processG protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
B0007399biological_processnervous system development
B0007602biological_processphototransduction
B0007635biological_processchemosensory behavior
B0009454biological_processaerotaxis
B0010628biological_processpositive regulation of gene expression
B0010754biological_processnegative regulation of cGMP-mediated signaling
B0016020cellular_componentmembrane
B0017071cellular_componentintracellular cyclic nucleotide activated cation channel complex
B0019722biological_processcalcium-mediated signaling
B0030425cellular_componentdendrite
B0030516biological_processregulation of axon extension
B0030553molecular_functioncGMP binding
B0034220biological_processmonoatomic ion transmembrane transport
B0034703cellular_componentcation channel complex
B0040010biological_processpositive regulation of growth rate
B0040040biological_processthermosensory behavior
B0042048biological_processolfactory behavior
B0042802molecular_functionidentical protein binding
B0042995cellular_componentcell projection
B0043052biological_processthermotaxis
B0044877molecular_functionprotein-containing complex binding
B0045664biological_processregulation of neuron differentiation
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0048609biological_processmulticellular organismal reproductive process
B0048812biological_processneuron projection morphogenesis
B0050907biological_processdetection of chemical stimulus involved in sensory perception
B0055085biological_processtransmembrane transport
B0055093biological_processresponse to hyperoxia
B0070482biological_processresponse to oxygen levels
B0071805biological_processpotassium ion transmembrane transport
B0097543cellular_componentciliary inversin compartment
B0097730cellular_componentnon-motile cilium
B0098655biological_processmonoatomic cation transmembrane transport
C0000166molecular_functionnucleotide binding
C0003031biological_processdetection of carbon dioxide
C0005216molecular_functionmonoatomic ion channel activity
C0005222molecular_functionintracellularly cAMP-activated cation channel activity
C0005223molecular_functionintracellularly cGMP-activated cation channel activity
C0005249molecular_functionvoltage-gated potassium channel activity
C0005886cellular_componentplasma membrane
C0005929cellular_componentcilium
C0006811biological_processmonoatomic ion transport
C0006813biological_processpotassium ion transport
C0006935biological_processchemotaxis
C0007199biological_processG protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
C0007399biological_processnervous system development
C0007602biological_processphototransduction
C0007635biological_processchemosensory behavior
C0009454biological_processaerotaxis
C0010628biological_processpositive regulation of gene expression
C0010754biological_processnegative regulation of cGMP-mediated signaling
C0016020cellular_componentmembrane
C0017071cellular_componentintracellular cyclic nucleotide activated cation channel complex
C0019722biological_processcalcium-mediated signaling
C0030425cellular_componentdendrite
C0030516biological_processregulation of axon extension
C0030553molecular_functioncGMP binding
C0034220biological_processmonoatomic ion transmembrane transport
C0034703cellular_componentcation channel complex
C0040010biological_processpositive regulation of growth rate
C0040040biological_processthermosensory behavior
C0042048biological_processolfactory behavior
C0042802molecular_functionidentical protein binding
C0042995cellular_componentcell projection
C0043052biological_processthermotaxis
C0044877molecular_functionprotein-containing complex binding
C0045664biological_processregulation of neuron differentiation
C0045944biological_processpositive regulation of transcription by RNA polymerase II
C0048609biological_processmulticellular organismal reproductive process
C0048812biological_processneuron projection morphogenesis
C0050907biological_processdetection of chemical stimulus involved in sensory perception
C0055085biological_processtransmembrane transport
C0055093biological_processresponse to hyperoxia
C0070482biological_processresponse to oxygen levels
C0071805biological_processpotassium ion transmembrane transport
C0097543cellular_componentciliary inversin compartment
C0097730cellular_componentnon-motile cilium
C0098655biological_processmonoatomic cation transmembrane transport
D0000166molecular_functionnucleotide binding
D0003031biological_processdetection of carbon dioxide
D0005216molecular_functionmonoatomic ion channel activity
D0005222molecular_functionintracellularly cAMP-activated cation channel activity
D0005223molecular_functionintracellularly cGMP-activated cation channel activity
D0005249molecular_functionvoltage-gated potassium channel activity
D0005886cellular_componentplasma membrane
D0005929cellular_componentcilium
D0006811biological_processmonoatomic ion transport
D0006813biological_processpotassium ion transport
D0006935biological_processchemotaxis
D0007199biological_processG protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
D0007399biological_processnervous system development
D0007602biological_processphototransduction
D0007635biological_processchemosensory behavior
D0009454biological_processaerotaxis
D0010628biological_processpositive regulation of gene expression
D0010754biological_processnegative regulation of cGMP-mediated signaling
D0016020cellular_componentmembrane
D0017071cellular_componentintracellular cyclic nucleotide activated cation channel complex
D0019722biological_processcalcium-mediated signaling
D0030425cellular_componentdendrite
D0030516biological_processregulation of axon extension
D0030553molecular_functioncGMP binding
D0034220biological_processmonoatomic ion transmembrane transport
D0034703cellular_componentcation channel complex
D0040010biological_processpositive regulation of growth rate
D0040040biological_processthermosensory behavior
D0042048biological_processolfactory behavior
D0042802molecular_functionidentical protein binding
D0042995cellular_componentcell projection
D0043052biological_processthermotaxis
D0044877molecular_functionprotein-containing complex binding
D0045664biological_processregulation of neuron differentiation
D0045944biological_processpositive regulation of transcription by RNA polymerase II
D0048609biological_processmulticellular organismal reproductive process
D0048812biological_processneuron projection morphogenesis
D0050907biological_processdetection of chemical stimulus involved in sensory perception
D0055085biological_processtransmembrane transport
D0055093biological_processresponse to hyperoxia
D0070482biological_processresponse to oxygen levels
D0071805biological_processpotassium ion transmembrane transport
D0097543cellular_componentciliary inversin compartment
D0097730cellular_componentnon-motile cilium
D0098655biological_processmonoatomic cation transmembrane transport
Functional Information from PDB Data
site_idAC1
Number of Residues9
Detailsbinding site for residue PCG A 801
ChainResidue
ACYS521
APHE558
AGLY559
AGLU560
ALEU561
ASER562
AARG575
ATHR576
AALA577

site_idAC2
Number of Residues7
Detailsbinding site for residue CPL A 802
ChainResidue
AASP147
ALEU148
ACYS172
ATYR197
ATRP204
APHE207
ACPL808

site_idAC3
Number of Residues2
Detailsbinding site for residue CPL A 803
ChainResidue
ATRP333
AILE387

site_idAC4
Number of Residues3
Detailsbinding site for residue CPL A 804
ChainResidue
ALEU326
ATRP329
AILE330

site_idAC5
Number of Residues2
Detailsbinding site for residue CPL A 805
ChainResidue
ATRP314
ATYR315

site_idAC6
Number of Residues2
Detailsbinding site for residue CPL A 806
ChainResidue
ATRP322
ALEU326

site_idAC7
Number of Residues2
Detailsbinding site for residue PX2 A 807
ChainResidue
ATRP333
AARG385

site_idAC8
Number of Residues4
Detailsbinding site for residue CPL A 808
ChainResidue
AVAL317
ATHR358
ALEU360
ACPL802

site_idAC9
Number of Residues6
Detailsbinding site for residue CPL B 802
ChainResidue
BASP147
BLEU148
BCYS172
BTYR197
BPHE207
BCPL808

site_idAD1
Number of Residues3
Detailsbinding site for residue CPL B 803
ChainResidue
BTRP333
BILE387
BLEU394

site_idAD2
Number of Residues3
Detailsbinding site for residue CPL B 804
ChainResidue
BLEU326
BTRP329
BILE330

site_idAD3
Number of Residues3
Detailsbinding site for residue CPL B 805
ChainResidue
BTRP314
BTYR315
BILE318

site_idAD4
Number of Residues1
Detailsbinding site for residue CPL B 806
ChainResidue
BTRP322

site_idAD5
Number of Residues2
Detailsbinding site for residue PX2 B 807
ChainResidue
BTRP333
BARG385

site_idAD6
Number of Residues4
Detailsbinding site for residue CPL B 808
ChainResidue
BVAL317
BTHR358
BLEU360
BCPL802

site_idAD7
Number of Residues6
Detailsbinding site for residue CPL C 802
ChainResidue
CASP147
CLEU148
CCYS172
CTYR197
CPHE207
CCPL808

site_idAD8
Number of Residues3
Detailsbinding site for residue CPL C 803
ChainResidue
CTRP333
CILE387
CLEU394

site_idAD9
Number of Residues3
Detailsbinding site for residue CPL C 804
ChainResidue
CLEU326
CTRP329
CILE330

site_idAE1
Number of Residues3
Detailsbinding site for residue CPL C 805
ChainResidue
CTRP314
CTYR315
CILE318

site_idAE2
Number of Residues1
Detailsbinding site for residue CPL C 806
ChainResidue
CTRP322

site_idAE3
Number of Residues2
Detailsbinding site for residue PX2 C 807
ChainResidue
CTRP333
CARG385

site_idAE4
Number of Residues4
Detailsbinding site for residue CPL C 808
ChainResidue
CVAL317
CTHR358
CLEU360
CCPL802

site_idAE5
Number of Residues6
Detailsbinding site for residue CPL D 802
ChainResidue
DASP147
DLEU148
DCYS172
DTYR197
DPHE207
DCPL808

site_idAE6
Number of Residues3
Detailsbinding site for residue CPL D 803
ChainResidue
DTRP333
DILE387
DLEU394

site_idAE7
Number of Residues3
Detailsbinding site for residue CPL D 804
ChainResidue
DLEU326
DTRP329
DILE330

site_idAE8
Number of Residues3
Detailsbinding site for residue CPL D 805
ChainResidue
DTRP314
DTYR315
DILE318

site_idAE9
Number of Residues1
Detailsbinding site for residue CPL D 806
ChainResidue
DTRP322

site_idAF1
Number of Residues2
Detailsbinding site for residue PX2 D 807
ChainResidue
DTRP333
DARG385

site_idAF2
Number of Residues4
Detailsbinding site for residue CPL D 808
ChainResidue
DVAL317
DTHR358
DLEU360
DCPL802

site_idAF3
Number of Residues10
Detailsbinding site for Di-peptide PCG B 801 and THR B 576
ChainResidue
BPHE558
BGLY559
BGLU560
BLEU561
BSER562
BARG574
BARG575
BALA577
BCYS521
BLYS523

site_idAF4
Number of Residues10
Detailsbinding site for Di-peptide PCG C 801 and THR C 576
ChainResidue
CCYS521
CLYS523
CPHE558
CGLY559
CGLU560
CLEU561
CSER562
CARG574
CARG575
CALA577

site_idAF5
Number of Residues10
Detailsbinding site for Di-peptide PCG D 801 and THR D 576
ChainResidue
DCYS521
DLYS523
DPHE558
DGLY559
DGLU560
DLEU561
DSER562
DARG574
DARG575
DALA577

Functional Information from PROSITE/UniProt
site_idPS00888
Number of Residues17
DetailsCNMP_BINDING_1 Cyclic nucleotide-binding domain signature 1. ICkKGDiGReMYIVkrG
ChainResidueDetails
AILE520-GLY536

site_idPS00889
Number of Residues24
DetailsCNMP_BINDING_2 Cyclic nucleotide-binding domain signature 2. FGElSIlniagskngnrRTAnVrS
ChainResidueDetails
APHE558-SER581

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1464
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
AMET1-ASN120
CTYR223-ARG251
CSER331-ASN386
CSER569-LYS733
DMET1-ASN120
DTYR223-ARG251
DSER331-ASN386
DSER569-LYS733
ATYR223-ARG251
ASER331-ASN386
ASER569-LYS733
BMET1-ASN120
BTYR223-ARG251
BSER331-ASN386
BSER569-LYS733
CMET1-ASN120

site_idSWS_FT_FI2
Number of Residues80
DetailsTRANSMEM: Helical; Name=H1 => ECO:0000255
ChainResidueDetails
APHE121-ALA141
BPHE121-ALA141
CPHE121-ALA141
DPHE121-ALA141

site_idSWS_FT_FI3
Number of Residues936
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
AARG142-ARG201
DARG142-ARG201
DTRP273-VAL309
DGLY408-LYS547
ATRP273-VAL309
AGLY408-LYS547
BARG142-ARG201
BTRP273-VAL309
BGLY408-LYS547
CARG142-ARG201
CTRP273-VAL309
CGLY408-LYS547

site_idSWS_FT_FI4
Number of Residues80
DetailsTRANSMEM: Helical; Name=H2 => ECO:0000255
ChainResidueDetails
AMET202-ASN222
BMET202-ASN222
CMET202-ASN222
DMET202-ASN222

site_idSWS_FT_FI5
Number of Residues80
DetailsTRANSMEM: Helical; Name=H3 => ECO:0000255
ChainResidueDetails
AILE252-ASN272
BILE252-ASN272
CILE252-ASN272
DILE252-ASN272

site_idSWS_FT_FI6
Number of Residues80
DetailsTRANSMEM: Helical; Name=H4 => ECO:0000255
ChainResidueDetails
AVAL310-ILE330
BVAL310-ILE330
CVAL310-ILE330
DVAL310-ILE330

site_idSWS_FT_FI7
Number of Residues80
DetailsTRANSMEM: Helical; Name=H5 => ECO:0000255
ChainResidueDetails
AILE387-VAL407
BILE387-VAL407
CILE387-VAL407
DILE387-VAL407

site_idSWS_FT_FI8
Number of Residues80
DetailsTRANSMEM: Helical; Name=H6 => ECO:0000255
ChainResidueDetails
AVAL548-GLY568
BVAL548-GLY568
CVAL548-GLY568
DVAL548-GLY568

site_idSWS_FT_FI9
Number of Residues8
DetailsBINDING: BINDING => ECO:0000255
ChainResidueDetails
AGLU560
AARG575
BGLU560
BARG575
CGLU560
CARG575
DGLU560
DARG575

218853

PDB entries from 2024-04-24

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