6WE8

YTH domain of human YTHDC1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
B	0003723	molecular_function	RNA binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue SO4 B 601

Chain	Residue
B	ARG451
B	GLU452
B	HOH707
B	HOH709
B	HOH743
B	HOH788
B	HOH800

---

site_id	AC2
Number of Residues	9
Details	binding site for residue SO4 B 602

Chain	Residue
A	GLN478
A	GLU479
A	HOH1353
B	GLY344
B	LYS347
B	HOH764
B	HOH818
A	LYS386
A	TRP465

---

site_id	AC3
Number of Residues	5
Details	binding site for residue SO4 B 603

Chain	Residue
B	SER419
B	HIS420
B	HIS421
B	ARG451
B	HOH819

---

site_id	AC4
Number of Residues	4
Details	binding site for residue SO4 B 604

Chain	Residue
B	ARG404
B	ARG475
B	ASP476
B	HOH740

---

site_id	AC5
Number of Residues	4
Details	binding site for residue EDO B 605

Chain	Residue
B	LYS385
B	ASN388
B	LYS457
B	HOH809

---

site_id	AC6
Number of Residues	4
Details	binding site for residue EDO B 606

Chain	Residue
B	HIS365
B	ARG404
B	GLU405
B	SER406

---

site_id	AC7
Number of Residues	4
Details	binding site for residue EDO B 607

Chain	Residue
B	GLY407
B	PHE455
B	LYS472
B	HOH776

---

site_id	AC8
Number of Residues	4
Details	binding site for residue EDO B 608

Chain	Residue
B	TRP377
B	SER378
B	HOH716
B	HOH794

---

site_id	AC9
Number of Residues	8
Details	binding site for residue EDO B 609

Chain	Residue
B	HIS365
B	VAL368
B	SER369
B	LYS372
B	VAL403
B	GLN410
B	HOH702
B	HOH852

---

site_id	AD1
Number of Residues	8
Details	binding site for residue GOL A 1201

Chain	Residue
A	ALA459
A	HIS460
A	HOH1305
A	HOH1306
A	HOH1328
B	LYS372
B	ALA373
B	ARG450

---

site_id	AD2
Number of Residues	2
Details	binding site for residue SO4 A 1202

Chain	Residue
A	HIS420
A	HIS421

---

site_id	AD3
Number of Residues	6
Details	binding site for residue EDO A 1203

Chain	Residue
A	LYS372
A	ARG450
A	ARG451
A	GLU452
A	HOH1309
A	HOH1374

---

site_id	AD4
Number of Residues	5
Details	binding site for residue SO4 A 1204

Chain	Residue
A	GLY344
A	SER346
A	LYS347
A	HOH1319
A	HOH1327

---

site_id	AD5
Number of Residues	3
Details	binding site for residue EDO A 1205

Chain	Residue
A	PHE391
A	ALA394
A	HOH1302

---

site_id	AD6
Number of Residues	3
Details	binding site for residue EDO A 1206

Chain	Residue
A	ASN367
A	TRP377
A	SER378

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	274
Details	Domain: {"description":"YTH","evidences":[{"source":"PROSITE-ProRule","id":"PRU00225","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31670957","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6RT4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RT5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RT6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RT7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25242552","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31670957","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6RT4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RT5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RT6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RT7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25242552","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---