6WCZ
CryoEM structure of full-length ZIKV NS5-hSTAT2 complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000785 | cellular_component | chromatin |
| A | 0000978 | molecular_function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| A | 0000981 | molecular_function | DNA-binding transcription factor activity, RNA polymerase II-specific |
| A | 0001932 | biological_process | regulation of protein phosphorylation |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0006357 | biological_process | regulation of transcription by RNA polymerase II |
| A | 0006952 | biological_process | defense response |
| A | 0007165 | biological_process | signal transduction |
| A | 0007259 | biological_process | cell surface receptor signaling pathway via JAK-STAT |
| A | 0042127 | biological_process | regulation of cell population proliferation |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0043434 | biological_process | response to peptide hormone |
| A | 0044389 | molecular_function | ubiquitin-like protein ligase binding |
| A | 0045944 | biological_process | positive regulation of transcription by RNA polymerase II |
| A | 0051607 | biological_process | defense response to virus |
| A | 0060337 | biological_process | type I interferon-mediated signaling pathway |
| A | 0060339 | biological_process | negative regulation of type I interferon-mediated signaling pathway |
| A | 0070721 | cellular_component | ISGF3 complex |
| A | 0090140 | biological_process | regulation of mitochondrial fission |
| A | 0090575 | cellular_component | RNA polymerase II transcription regulator complex |
| B | 0003968 | molecular_function | RNA-directed RNA polymerase activity |
| B | 0004482 | molecular_function | mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
| B | 0004483 | molecular_function | methyltransferase cap1 activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0008168 | molecular_function | methyltransferase activity |
| B | 0032259 | biological_process | methylation |
| B | 0039694 | biological_process | viral RNA genome replication |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue ZN B 1001 |
| Chain | Residue |
| B | GLU439 |
| B | HIS443 |
| B | CYS448 |
| B | SER450 |
| B | CYS451 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 1002 |
| Chain | Residue |
| B | HIS714 |
| B | ASN716 |
| B | CYS730 |
| B | CYS849 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23139419","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23139419","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 150 |
| Details | Domain: {"description":"RdRp catalytic","evidences":[{"source":"PROSITE-ProRule","id":"PRU00539","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00924","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"28291746","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28345656","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00924","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"28291746","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00924","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"27386922","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27399257","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29080786","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 7 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"28291746","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28345596","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28345656","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 3 |
| Details | Region: {"description":"SUMO-interacting motif (SIM)","evidences":[{"source":"UniProtKB","id":"A0A024B7W1","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 4 |
| Details | Region: {"description":"Interaction with host SCRIB","evidences":[{"source":"UniProtKB","id":"Q01299","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 6 |
| Details | Motif: {"description":"Nuclear localization signal (NLS)","evidences":[{"source":"PubMed","id":"30848123","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 4 |
| Details | Active site: {"description":"For 2'-O-MTase activity","evidences":[{"source":"UniProtKB","id":"Q6YMS4","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 15 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"A0A024B7W1","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"28345656","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"28291746","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28345656","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 3 |
| Details | Site: {"description":"Essential for 2'-O-methyltransferase activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU00924","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 1 |
| Details | Site: {"description":"Essential for 2'-O-methyltransferase and N-7 methyltransferase activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU00924","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI18 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P03314","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
