Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6WCA

Human closed state TMEM175 in KCl

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005267	molecular_function	potassium channel activity
A	0005515	molecular_function	protein binding
A	0005764	cellular_component	lysosome
A	0005765	cellular_component	lysosomal membrane
A	0005768	cellular_component	endosome
A	0006811	biological_process	monoatomic ion transport
A	0006813	biological_process	potassium ion transport
A	0010008	cellular_component	endosome membrane
A	0015252	molecular_function	proton channel activity
A	0016020	cellular_component	membrane
A	0022841	molecular_function	potassium ion leak channel activity
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0035751	biological_process	regulation of lysosomal lumen pH
A	0035752	biological_process	lysosomal lumen pH elevation
A	0050544	molecular_function	arachidonate binding
A	0070050	biological_process	neuron cellular homeostasis
A	0071805	biological_process	potassium ion transmembrane transport
A	0090385	biological_process	phagosome-lysosome fusion
A	1902600	biological_process	proton transmembrane transport
B	0005267	molecular_function	potassium channel activity
B	0005515	molecular_function	protein binding
B	0005764	cellular_component	lysosome
B	0005765	cellular_component	lysosomal membrane
B	0005768	cellular_component	endosome
B	0006811	biological_process	monoatomic ion transport
B	0006813	biological_process	potassium ion transport
B	0010008	cellular_component	endosome membrane
B	0015252	molecular_function	proton channel activity
B	0016020	cellular_component	membrane
B	0022841	molecular_function	potassium ion leak channel activity
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0035751	biological_process	regulation of lysosomal lumen pH
B	0035752	biological_process	lysosomal lumen pH elevation
B	0050544	molecular_function	arachidonate binding
B	0070050	biological_process	neuron cellular homeostasis
B	0071805	biological_process	potassium ion transmembrane transport
B	0090385	biological_process	phagosome-lysosome fusion
B	1902600	biological_process	proton transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	binding site for residue K A 701

Chain	Residue
A	SER38

site_id	AC2
Number of Residues	3
Details	binding site for residue K A 702

Chain	Residue
A	ALA42
A	GLY267
B	K702

site_id	AC3
Number of Residues	1
Details	binding site for residue K B 701

Chain	Residue
B	SER38

site_id	AC4
Number of Residues	3
Details	binding site for residue K B 702

Chain	Residue
A	K702
B	ALA42
B	GLY267

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	44
Details	Transmembrane: {"description":"Helical; Name=TM1-1","evidences":[{"source":"PubMed","id":"32228865","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6WC9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WCA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WCB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WCC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	140
Details	Topological domain: {"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	44
Details	Transmembrane: {"description":"Helical; Name=TM2-1","evidences":[{"source":"PubMed","id":"32228865","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6WC9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WCA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WCB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WCC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	58
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	42
Details	Transmembrane: {"description":"Helical; Name=TM3-1","evidences":[{"source":"PubMed","id":"32228865","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6WC9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WCA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WCB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WCC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	42
Details	Transmembrane: {"description":"Helical; Name=TM4-1","evidences":[{"source":"PubMed","id":"32228865","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6WC9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WCA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WCB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WCC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	48
Details	Transmembrane: {"description":"Helical; Name=TM1-2","evidences":[{"source":"PubMed","id":"32228865","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6WC9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WCA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WCB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WCC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	44
Details	Transmembrane: {"description":"Helical; Name=TM2-2","evidences":[{"source":"PubMed","id":"32228865","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6WC9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WCA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WCB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WCC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	42
Details	Transmembrane: {"description":"Helical; Name=TM3-2","evidences":[{"source":"PubMed","id":"32228865","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6WC9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WCA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WCB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WCC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=TM4-2","evidences":[{"source":"PubMed","id":"32228865","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6WC9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WCA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WCB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WCC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	46
Details	Transmembrane: {"description":"Helical; Name=TM5-2","evidences":[{"source":"PubMed","id":"32228865","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6WC9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WCA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WCB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WCC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	52
Details	Transmembrane: {"description":"Helical; Name=TM6-2","evidences":[{"source":"PubMed","id":"32228865","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6WC9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WCA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WCB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WCC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	10
Details	Region: {"description":"Short helix H1-1","evidences":[{"source":"UniProtKB","id":"K9UJK2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	12
Details	Region: {"description":"Short helix H2-1","evidences":[{"source":"UniProtKB","id":"K9UJK2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	16
Details	Region: {"description":"Short helix H1-2","evidences":[{"source":"UniProtKB","id":"K9UJK2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	12
Details	Region: {"description":"Short helix H2-2","evidences":[{"source":"UniProtKB","id":"K9UJK2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	12
Details	Motif: {"description":"RxxxFSD motif 1","evidences":[{"source":"PubMed","id":"26317472","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	12
Details	Motif: {"description":"RxxxFSD motif 2","evidences":[{"source":"PubMed","id":"26317472","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	2
Details	Site: {"description":"Hydrophobic filter residue 1-1","evidences":[{"source":"PubMed","id":"28723891","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	2
Details	Site: {"description":"Hydrophobic filter residue 2-1","evidences":[{"source":"UniProtKB","id":"K9UJK2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	2
Details	Site: {"description":"Hydrophobic filter residue 3-1","evidences":[{"source":"UniProtKB","id":"K9UJK2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	2
Details	Site: {"description":"Hydrophobic filter residue 1-2","evidences":[{"source":"PubMed","id":"28723891","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI23
Number of Residues	2
Details	Site: {"description":"Hydrophobic filter residue 2-2","evidences":[{"source":"UniProtKB","id":"K9UJK2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI24
Number of Residues	2
Details	Site: {"description":"Hydrophobic filter residue 3-2","evidences":[{"source":"UniProtKB","id":"K9UJK2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)