6WAA

K. pneumoniae Topoisomerase IV (ParE-ParC) in complex with DNA and compound 34 (7-[(1S,5R)-1-amino-3-azabicyclo[3.1.0]hexan-3-yl]-4-(aminomethyl)-1-cyclopropyl-3,6-difluoro-8-methylquinolin-2(1H)-one)

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0003677	molecular_function	DNA binding
B	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
B	0005524	molecular_function	ATP binding
B	0005694	cellular_component	chromosome
B	0006259	biological_process	DNA metabolic process
B	0006265	biological_process	DNA topological change
D	0003677	molecular_function	DNA binding
D	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
D	0005524	molecular_function	ATP binding
D	0005694	cellular_component	chromosome
D	0006259	biological_process	DNA metabolic process
D	0006265	biological_process	DNA topological change
F	0003677	molecular_function	DNA binding
F	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
F	0005524	molecular_function	ATP binding
F	0005694	cellular_component	chromosome
F	0006259	biological_process	DNA metabolic process
F	0006265	biological_process	DNA topological change
H	0003677	molecular_function	DNA binding
H	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
H	0005524	molecular_function	ATP binding
H	0005694	cellular_component	chromosome
H	0006259	biological_process	DNA metabolic process
H	0006265	biological_process	DNA topological change

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue MPD B 1501

Chain	Residue
B	GLN1269
B	ALA1317
B	THR1318
B	THR1319
B	ASP1320
B	GLU1322
J	DT24
J	DA25

---

site_id	AC2
Number of Residues	1
Details	binding site for residue MPD B 1502

Chain	Residue
B	ARG1372

---

site_id	AC3
Number of Residues	1
Details	binding site for residue MG B 1503

Chain	Residue
B	LYS1113

---

site_id	AC4
Number of Residues	2
Details	binding site for residue MG B 1504

Chain	Residue
B	ASP491
B	ASP493

---

site_id	AC5
Number of Residues	1
Details	binding site for residue CL B 1505

Chain	Residue
B	ARG1365

---

site_id	AC6
Number of Residues	4
Details	binding site for residue MPD D 1501

Chain	Residue
D	LYS1113
D	PHE1115
K	DA13
K	DT14

---

site_id	AC7
Number of Residues	3
Details	binding site for residue MG D 1502

Chain	Residue
D	GLU419
D	ASP491
D	ASP493

---

site_id	AC8
Number of Residues	3
Details	binding site for residue MPD F 1501

Chain	Residue
F	ARG1372
F	ALA1416
F	GLU1419

---

site_id	AC9
Number of Residues	2
Details	binding site for residue MG F 1503

Chain	Residue
F	ASP491
F	ASP493

---

site_id	AD1
Number of Residues	1
Details	binding site for residue MG F 1504

Chain	Residue
M	DA3

---

site_id	AD2
Number of Residues	3
Details	binding site for residue MPD H 1501

Chain	Residue
H	LYS1113
H	PHE1115
O	DA13

---

site_id	AD3
Number of Residues	4
Details	binding site for residue MPD H 1502

Chain	Residue
H	ARG1372
H	LEU1379
H	HIS1424
H	GLU1429

---

site_id	AD4
Number of Residues	2
Details	binding site for residue MG H 1503

Chain	Residue
H	ASP491
H	ASP493

---

site_id	AD5
Number of Residues	1
Details	binding site for residue MG I 101

Chain	Residue
I	DG8

---

site_id	AD6
Number of Residues	8
Details	binding site for residue TNJ J 101

Chain	Residue
B	LYS442
B	GLY443
B	GLU461
B	SER1080
I	DT11
J	DC15
J	DA16
K	DG12

---

site_id	AD7
Number of Residues	7
Details	binding site for residue TNJ J 102

Chain	Residue
D	LYS442
D	GLU461
D	SER1080
J	DG12
K	DC15
K	DA16
L	DT11

---

site_id	AD8
Number of Residues	2
Details	binding site for residue MG M 101

Chain	Residue
M	DT7
M	DG8

---

site_id	AD9
Number of Residues	8
Details	binding site for residue TNJ N 101

Chain	Residue
H	LYS442
H	GLY443
H	GLU461
H	SER1080
N	DG12
O	DC15
O	DA16
P	DT11

---

site_id	AE1
Number of Residues	8
Details	binding site for residue TNJ N 102

Chain	Residue
F	LYS442
F	GLU461
F	SER1080
H	ARG1119
M	DT11
N	DC15
N	DA16
O	DG12

---

site_id	AE2
Number of Residues	3
Details	binding site for residue MG O 101

Chain	Residue
O	DT17
P	DG8
P	DT9

---

Functional Information from PROSITE/UniProt

site_id	PS00177
Number of Residues	9
Details	TOPOISOMERASE_II DNA topoisomerase II signature. LVEGDSAGG

Chain	Residue	Details
B	LEU417-GLY425

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