6W88

K2P2.1 (TREK-1):ML335 complex, 30 mM K+

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005267	molecular_function	potassium channel activity
A	0016020	cellular_component	membrane
A	0071805	biological_process	potassium ion transmembrane transport
B	0005267	molecular_function	potassium channel activity
B	0016020	cellular_component	membrane
B	0071805	biological_process	potassium ion transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue Q6F A 401

Chain	Residue
A	SER131
A	LYS271
A	VAL274
A	TRP275
A	ILE278
A	PHE134
A	GLY137
A	THR138
A	ILE148
A	VAL258
A	ALA259
A	GLY260
A	GLY261

---

site_id	AC2
Number of Residues	1
Details	binding site for residue CD A 402

Chain	Residue
A	ASP263

---

site_id	AC3
Number of Residues	1
Details	binding site for residue D12 A 403

Chain	Residue
B	ALA238

---

site_id	AC4
Number of Residues	2
Details	binding site for residue D12 A 404

Chain	Residue
A	LEU221
A	LEU225

---

site_id	AC5
Number of Residues	1
Details	binding site for residue R16 A 408

Chain	Residue
A	GLY154

---

site_id	AC6
Number of Residues	9
Details	binding site for residue K A 410

Chain	Residue
A	GLY144
A	PHE145
A	GLY253
A	PHE254
B	GLY144
B	PHE145
B	GLY253
B	PHE254
B	K412

---

site_id	AC7
Number of Residues	10
Details	binding site for residue K A 411

Chain	Residue
A	THR142
A	ILE143
A	THR251
A	ILE252
A	K412
B	THR142
B	ILE143
B	THR251
B	ILE252
B	K412

---

site_id	AC8
Number of Residues	5
Details	binding site for residue K A 412

Chain	Residue
A	THR142
A	THR251
A	K411
B	THR142
B	THR251

---

site_id	AC9
Number of Residues	1
Details	binding site for residue UND A 413

Chain	Residue
A	THR303

---

site_id	AD1
Number of Residues	1
Details	binding site for residue CD B 401

Chain	Residue
B	HIS126

---

site_id	AD2
Number of Residues	4
Details	binding site for residue CD B 402

Chain	Residue
A	GLU309
A	HIS313
B	GLU309
B	HIS313

---

site_id	AD3
Number of Residues	1
Details	binding site for residue CD B 403

Chain	Residue
B	ASP128

---

site_id	AD4
Number of Residues	11
Details	binding site for residue Q6F B 404

Chain	Residue
B	HIS126
B	SER131
B	PHE134
B	GLY137
B	ASN147
B	ALA259
B	GLY260
B	GLY261
B	VAL274
B	TRP275
B	ILE278

---

site_id	AD5
Number of Residues	1
Details	binding site for residue D12 B 405

Chain	Residue
B	ILE60

---

site_id	AD6
Number of Residues	1
Details	binding site for residue LNK B 407

Chain	Residue
B	LEU129

---

site_id	AD7
Number of Residues	1
Details	binding site for residue OCT B 408

Chain	Residue
B	ASP268

---

site_id	AD8
Number of Residues	1
Details	binding site for residue R16 B 411

Chain	Residue
B	THR49

---

site_id	AD9
Number of Residues	10
Details	binding site for residue K B 412

Chain	Residue
A	ILE143
A	GLY144
A	ILE252
A	GLY253
A	K410
A	K411
B	ILE143
B	GLY144
B	ILE252
B	GLY253

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	160
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	52
Details	Intramembrane: {"description":"Pore-forming; Name=Pore-forming 1","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	29
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	60
Details	Intramembrane: {"description":"Pore-forming; Name=Pore-forming 2","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	20
Details	Region: {"description":"Important for GNG4 binding and L-glutamate release in astrocytes","evidences":[{"source":"UniProtKB","id":"Q920B6","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	10
Details	Region: {"description":"Selectivity filter 1","evidences":[{"source":"UniProtKB","id":"Q920B6","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	10
Details	Region: {"description":"Selectivity filter 2","evidences":[{"source":"UniProtKB","id":"Q920B6","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	52
Details	Region: {"description":"Interaction with AKAP5","evidences":[{"source":"PubMed","id":"17110924","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"28693035","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33127683","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6W7B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6W83","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"33127683","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6W83","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"28693035","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6W7B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6W83","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	4
Details	Site: {"description":"pH sensor","evidences":[{"source":"PubMed","id":"19667202","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27035963","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	3
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---