Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6W6O

NaChBac-Nav1.7VSDII chimera and HWTX-IV complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0005261	molecular_function	monoatomic cation channel activity
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0055085	biological_process	transmembrane transport
C	0005576	cellular_component	extracellular region
C	0008200	molecular_function	ion channel inhibitor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005261	molecular_function	monoatomic cation channel activity
D	0005886	cellular_component	plasma membrane
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0055085	biological_process	transmembrane transport
E	0005576	cellular_component	extracellular region
E	0008200	molecular_function	ion channel inhibitor activity
F	0005216	molecular_function	monoatomic ion channel activity
F	0005261	molecular_function	monoatomic cation channel activity
F	0005886	cellular_component	plasma membrane
F	0006811	biological_process	monoatomic ion transport
F	0016020	cellular_component	membrane
F	0055085	biological_process	transmembrane transport
G	0005576	cellular_component	extracellular region
G	0008200	molecular_function	ion channel inhibitor activity
H	0005216	molecular_function	monoatomic ion channel activity
H	0005261	molecular_function	monoatomic cation channel activity
H	0005886	cellular_component	plasma membrane
H	0006811	biological_process	monoatomic ion transport
H	0016020	cellular_component	membrane
H	0055085	biological_process	transmembrane transport
I	0005576	cellular_component	extracellular region
I	0008200	molecular_function	ion channel inhibitor activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue POV A 301

Chain	Residue
A	PHE205
A	ALA206
A	TRP210
A	TRP212
F	POV301

site_id	AC2
Number of Residues	7
Details	binding site for residue POV A 302

Chain	Residue
A	TRP210
A	SER211
H	SER113
A	PHE157
A	PHE161
A	LEU168
A	VAL208

site_id	AC3
Number of Residues	5
Details	binding site for residue POV A 303

Chain	Residue
A	LEU34
A	ILE48
D	ILE156
D	LEU184
F	POV302

site_id	AC4
Number of Residues	5
Details	binding site for residue POV D 301

Chain	Residue
D	PHE205
D	ALA206
D	TRP210
D	TRP212
H	POV301

site_id	AC5
Number of Residues	7
Details	binding site for residue POV D 302

Chain	Residue
A	SER113
D	PHE157
D	PHE161
D	LEU168
D	VAL208
D	TRP210
D	SER211

site_id	AC6
Number of Residues	5
Details	binding site for residue POV D 303

Chain	Residue
D	LEU34
D	ILE48
F	ILE156
F	LEU184
H	POV302

site_id	AC7
Number of Residues	5
Details	binding site for residue POV F 301

Chain	Residue
A	POV301
F	LEU34
F	ILE48
H	ILE156
H	LEU184

site_id	AC8
Number of Residues	5
Details	binding site for residue POV F 302

Chain	Residue
A	POV303
F	PHE205
F	ALA206
F	TRP210
F	TRP212

site_id	AC9
Number of Residues	7
Details	binding site for residue POV F 303

Chain	Residue
D	SER113
F	PHE157
F	PHE161
F	LEU168
F	VAL208
F	TRP210
F	SER211

site_id	AD1
Number of Residues	5
Details	binding site for residue POV H 301

Chain	Residue
A	ILE156
A	LEU184
D	POV301
H	LEU34
H	ILE48

site_id	AD2
Number of Residues	5
Details	binding site for residue POV H 302

Chain	Residue
D	POV303
H	PHE205
H	ALA206
H	TRP210
H	TRP212

site_id	AD3
Number of Residues	7
Details	binding site for residue POV H 303

Chain	Residue
F	SER113
H	PHE157
H	PHE161
H	LEU168
H	VAL208
H	TRP210
H	SER211

Functional Information from PROSITE/UniProt

site_id	PS60021
Number of Residues	30
Details	HWTX_1 Huwentoxin-1 family signature. CLeIfkaCnpsndqCCkssklvCsrktRWC

Chain	Residue	Details
C	CYS2-CYS31

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	96
Details	Transmembrane: {"description":"Helical; Name=S2 of repeat II","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	64
Details	Transmembrane: {"description":"Helical; Name=S3 of repeat II","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	32
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	64
Details	Transmembrane: {"description":"Helical; Name=S4 of repeat II","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	64
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	88
Details	Transmembrane: {"description":"Helical; Name=S5 of repeat II","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	104
Details	Transmembrane: {"description":"Helical; Name=S6 of repeat II","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	8
Details	Site: {"description":"Is directly targeted by the spider protoxin-II","evidences":[{"source":"PubMed","id":"30661758","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	20
Details	Site: {"description":"Binds to the extracellular loop of voltage sensor domain II of sodium channels (Nav1.2/SCN2A and Nav1.7/SCN9A)","evidences":[{"source":"PubMed","id":"23760503","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	4
Details	Modified residue: {"description":"Pyrrolidone carboxylic acid (Glu); partial","evidences":[{"source":"PubMed","id":"23826086","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	4
Details	Modified residue: {"description":"Isoleucine amide","evidences":[{"source":"PubMed","id":"12228241","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)