6W66

The structure of the F64A, S172A mutant Keap1-BTB domain in complex with SKP1-FBXL17

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000082	biological_process	G1/S transition of mitotic cell cycle
A	0000209	biological_process	protein polyubiquitination
A	0000785	cellular_component	chromatin
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005813	cellular_component	centrosome
A	0005829	cellular_component	cytosol
A	0006338	biological_process	chromatin remodeling
A	0006355	biological_process	regulation of DNA-templated transcription
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0006879	biological_process	intracellular iron ion homeostasis
A	0007346	biological_process	regulation of mitotic cell cycle
A	0008013	molecular_function	beta-catenin binding
A	0010564	biological_process	regulation of cell cycle process
A	0010824	biological_process	regulation of centrosome duplication
A	0014033	biological_process	neural crest cell differentiation
A	0016567	biological_process	protein ubiquitination
A	0019005	cellular_component	SCF ubiquitin ligase complex
A	0019904	molecular_function	protein domain specific binding
A	0030510	biological_process	regulation of BMP signaling pathway
A	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
A	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
A	0031507	biological_process	heterochromatin formation
A	0031519	cellular_component	PcG protein complex
A	0032006	biological_process	regulation of TOR signaling
A	0042752	biological_process	regulation of circadian rhythm
A	0042981	biological_process	regulation of apoptotic process
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0045892	biological_process	negative regulation of DNA-templated transcription
A	0050727	biological_process	regulation of inflammatory response
A	0051124	biological_process	synaptic assembly at neuromuscular junction
A	0051298	biological_process	centrosome duplication
A	0051457	biological_process	maintenance of protein location in nucleus
A	0051726	biological_process	regulation of cell cycle
A	0060173	biological_process	limb development
A	0060271	biological_process	cilium assembly
A	0070936	biological_process	protein K48-linked ubiquitination
A	0097602	molecular_function	cullin family protein binding
A	0140677	molecular_function	molecular function activator activity
A	0160072	molecular_function	ubiquitin ligase complex scaffold activity
A	1901524	biological_process	regulation of mitophagy
A	1904415	biological_process	regulation of xenophagy
A	1990444	molecular_function	F-box domain binding
A	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
A	1990757	molecular_function	ubiquitin ligase activator activity
A	2000001	biological_process	regulation of DNA damage checkpoint

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)","evidences":[{"source":"PubMed","id":"25114211","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	72
Details	Domain: {"description":"BTB","evidences":[{"source":"PROSITE-ProRule","id":"PRU00037","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Site: {"description":"Sensor for electrophilic agents","evidences":[{"source":"PubMed","id":"18251510","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29590092","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"S-nitrosocysteine; alternate","evidences":[{"source":"UniProtKB","id":"Q9Z2X8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Cross-link: {"description":"N5-[4-(S-L-cysteinyl)-5-methyl-1H-imidazol-2-yl]-L-ornithine (Arg-Cys) (interchain with C-151 in KEAP1)","evidences":[{"source":"PubMed","id":"30323285","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Cross-link: {"description":"N5-[4-(S-L-cysteinyl)-5-methyl-1H-imidazol-2-yl]-L-ornithine (Cys-Arg) (interchain with R-135 in KEAP1)","evidences":[{"source":"PubMed","id":"30323285","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---