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6W66

The structure of the F64A, S172A mutant Keap1-BTB domain in complex with SKP1-FBXL17

Functional Information from GO Data
ChainGOidnamespacecontents
A0000209biological_processprotein polyubiquitination
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005813cellular_componentcentrosome
A0005829cellular_componentcytosol
A0006338biological_processchromatin remodeling
A0006511biological_processubiquitin-dependent protein catabolic process
A0006513biological_processprotein monoubiquitination
A0008013molecular_functionbeta-catenin binding
A0016567biological_processprotein ubiquitination
A0019005cellular_componentSCF ubiquitin ligase complex
A0019904molecular_functionprotein domain specific binding
A0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
A0031467cellular_componentCul7-RING ubiquitin ligase complex
A0031519cellular_componentPcG protein complex
A0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
A0051457biological_processmaintenance of protein location in nucleus
A0070936biological_processprotein K48-linked ubiquitination
A0097602molecular_functioncullin family protein binding
A0140677molecular_functionmolecular function activator activity
A0160072molecular_functionubiquitin ligase complex scaffold activity
A1904668biological_processpositive regulation of ubiquitin protein ligase activity
A1990444molecular_functionF-box domain binding
A1990756molecular_functionubiquitin-like ligase-substrate adaptor activity
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsSITE: Sensor for electrophilic agents => ECO:0000269|PubMed:18251510, ECO:0000269|PubMed:29590092
ChainResidueDetails
CCYS151

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: S-nitrosocysteine; alternate => ECO:0000250|UniProtKB:Q9Z2X8
ChainResidueDetails
CCYS151

site_idSWS_FT_FI3
Number of Residues1
DetailsCROSSLNK: N5-[4-(S-L-cysteinyl)-5-methyl-1H-imidazol-2-yl]-L-ornithine (Arg-Cys) (interchain with C-151 in KEAP1) => ECO:0000269|PubMed:30323285
ChainResidueDetails
CARG135

site_idSWS_FT_FI4
Number of Residues2
DetailsCROSSLNK: N5-[4-(S-L-cysteinyl)-5-methyl-1H-imidazol-2-yl]-L-ornithine (Cys-Arg) (interchain with R-135 in KEAP1) => ECO:0000269|PubMed:30323285
ChainResidueDetails
CCYS151

221051

PDB entries from 2024-06-12

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