6W5S
NPC1 structure in GDN micelles at pH 8.0
Functional Information from GO Data
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 238 |
Details | TOPO_DOM: Lumenal => ECO:0000269|PubMed:27238017 |
Chain | Residue | Details |
A | GLN23-THR261 |
site_id | SWS_FT_FI2 |
Number of Residues | 20 |
Details | TRANSMEM: Helical => ECO:0000269|PubMed:27238017 |
Chain | Residue | Details |
A | ILE262-VAL282 |
site_id | SWS_FT_FI3 |
Number of Residues | 67 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:27238017 |
Chain | Residue | Details |
A | PHE283-PRO350 |
site_id | SWS_FT_FI4 |
Number of Residues | 40 |
Details | TRANSMEM: Helical => ECO:0000269|PubMed:27238017, ECO:0000269|PubMed:28784760 |
Chain | Residue | Details |
A | GLY351-VAL371 | |
A | VAL621-HIS641 |
site_id | SWS_FT_FI5 |
Number of Residues | 248 |
Details | TOPO_DOM: Lumenal => ECO:0000269|PubMed:27238017, ECO:0000269|PubMed:28784760 |
Chain | Residue | Details |
A | ARG372-ASP620 |
site_id | SWS_FT_FI6 |
Number of Residues | 142 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:28784760 |
Chain | Residue | Details |
A | MET642-LYS653 | |
A | GLN707-GLU730 | |
A | GLY784-ASP832 | |
A | CYS1119-ALA1124 | |
A | THR1172-MET1194 | |
A | PRO1245-PHE1278 |
site_id | SWS_FT_FI7 |
Number of Residues | 204 |
Details | TRANSMEM: Helical => ECO:0000269|PubMed:28784760 |
Chain | Residue | Details |
A | VAL686-VAL706 | |
A | VAL731-LEU751 | |
A | PHE760-LEU783 | |
A | TRP833-LEU853 | |
A | THR1098-GLY1118 | |
A | VAL1125-TRP1145 | |
A | ALA1151-ILE1171 | |
A | GLY1195-PHE1215 | |
A | PHE1224-LEU1244 | |
A | VAL654-PHE675 |
site_id | SWS_FT_FI8 |
Number of Residues | 270 |
Details | TOPO_DOM: Lumenal => ECO:0000269|PubMed:28784760 |
Chain | Residue | Details |
A | SER676-ILE685 | |
A | SER752-THR759 | |
A | ASN854-ASP1097 | |
A | GLY1146-ASN1150 | |
A | ALA1216-ILE1223 |
site_id | SWS_FT_FI9 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:19563754, ECO:0000305|PubMed:27238017, ECO:0007744|PDB:3GKI, ECO:0007744|PDB:3GKJ |
Chain | Residue | Details |
A | ASN41 | |
A | GLN79 |
site_id | SWS_FT_FI10 |
Number of Residues | 1 |
Details | SITE: Important for cholesterol binding => ECO:0000269|PubMed:19563754 |
Chain | Residue | Details |
A | PHE108 |
site_id | SWS_FT_FI11 |
Number of Residues | 1 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000305|PubMed:10821832 |
Chain | Residue | Details |
A | ASN70 |
site_id | SWS_FT_FI12 |
Number of Residues | 2 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:27238017, ECO:0000305|PubMed:10821832, ECO:0007744|PDB:3JD8 |
Chain | Residue | Details |
A | ASN122 | |
A | ASN185 |
site_id | SWS_FT_FI13 |
Number of Residues | 1 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:27238017, ECO:0007744|PDB:3JD8 |
Chain | Residue | Details |
A | ASN135 |
site_id | SWS_FT_FI14 |
Number of Residues | 1 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine; atypical => ECO:0000269|PubMed:19563754, ECO:0000269|PubMed:27238017, ECO:0007744|PDB:3GKI, ECO:0007744|PDB:3GKJ, ECO:0007744|PDB:3JD8 |
Chain | Residue | Details |
A | ASN158 |
site_id | SWS_FT_FI15 |
Number of Residues | 1 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19563754, ECO:0000269|PubMed:27238017, ECO:0007744|PDB:3GKI, ECO:0007744|PDB:3GKJ, ECO:0007744|PDB:3JD8 |
Chain | Residue | Details |
A | ASN222 |
site_id | SWS_FT_FI16 |
Number of Residues | 6 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:28784760, ECO:0007744|PDB:5U74 |
Chain | Residue | Details |
A | ASN452 | |
A | ASN459 | |
A | ASN916 | |
A | ASN931 | |
A | ASN961 | |
A | ASN968 |
site_id | SWS_FT_FI17 |
Number of Residues | 2 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:26846330, ECO:0000269|PubMed:28784760, ECO:0007744|PDB:5HNS, ECO:0007744|PDB:5U74 |
Chain | Residue | Details |
A | ASN478 | |
A | ASN557 |
site_id | SWS_FT_FI18 |
Number of Residues | 1 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:26846330, ECO:0000269|PubMed:27238017, ECO:0000269|PubMed:28784760, ECO:0007744|PDB:3JD8, ECO:0007744|PDB:5HNS, ECO:0007744|PDB:5U74 |
Chain | Residue | Details |
A | ASN524 |
site_id | SWS_FT_FI19 |
Number of Residues | 1 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:26846330, ECO:0000269|PubMed:27238017, ECO:0007744|PDB:3JD8, ECO:0007744|PDB:5HNS |
Chain | Residue | Details |
A | ASN572 |
site_id | SWS_FT_FI20 |
Number of Residues | 1 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:26846330, ECO:0000269|PubMed:27238017, ECO:0000269|PubMed:28784760, ECO:0007744|PDB:3JD8, ECO:0007744|PDB:5HNS, ECO:0007744|PDB:5U74 |
Chain | Residue | Details |
A | ASN598 |
site_id | SWS_FT_FI21 |
Number of Residues | 1 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:27238017, ECO:0000269|PubMed:28784760, ECO:0007744|PDB:3JD8, ECO:0007744|PDB:5U74 |
Chain | Residue | Details |
A | ASN1064 |
site_id | SWS_FT_FI22 |
Number of Residues | 1 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
Chain | Residue | Details |
A | ASN1072 |