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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6W5R

NPC1 structure in Nanodisc

Functional Information from GO Data
ChainGOidnamespacecontents
A0005319molecular_functionlipid transporter activity
A0016020cellular_componentmembrane
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues238
DetailsTopological domain: {"description":"Lumenal","evidences":[{"source":"PubMed","id":"27238017","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues20
DetailsTransmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"27238017","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues40
DetailsTransmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"27238017","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28784760","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues248
DetailsTopological domain: {"description":"Lumenal","evidences":[{"source":"PubMed","id":"27238017","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28784760","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues61
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"28784760","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues204
DetailsTransmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"28784760","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues270
DetailsTopological domain: {"description":"Lumenal","evidences":[{"source":"PubMed","id":"28784760","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues165
DetailsDomain: {"description":"SSD","evidences":[{"source":"PROSITE-ProRule","id":"PRU00199","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues30
DetailsRegion: {"description":"Important for cholesterol binding and cholesterol transfer from NPC1 to liposomes"}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"19563754","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27238017","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3GKI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GKJ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues1
DetailsSite: {"description":"Important for cholesterol binding","evidences":[{"source":"PubMed","id":"19563754","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"10821832","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"27238017","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10821832","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3JD8","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27238017","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3JD8","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine; atypical","evidences":[{"source":"PubMed","id":"19563754","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27238017","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3GKI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GKJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3JD8","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19563754","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27238017","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3GKI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GKJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3JD8","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues6
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"28784760","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5U74","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"26846330","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28784760","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5HNS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5U74","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26846330","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27238017","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28784760","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3JD8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5HNS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5U74","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"26846330","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27238017","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3JD8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5HNS","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"26846330","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27238017","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28784760","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3JD8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5HNS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5U74","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"27238017","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28784760","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3JD8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5U74","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

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PDB entries from 2025-07-23

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