6W3K
Structure of unphosphorylated human IRE1 bound to G-9807
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004521 | molecular_function | RNA endonuclease activity |
| A | 0004540 | molecular_function | RNA nuclease activity |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004674 | molecular_function | protein serine/threonine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006397 | biological_process | mRNA processing |
| A | 0006468 | biological_process | protein phosphorylation |
| A | 0030968 | biological_process | endoplasmic reticulum unfolded protein response |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | binding site for residue SJS A 1001 |
| Chain | Residue |
| A | LEU577 |
| A | ALA647 |
| A | GLU651 |
| A | HIS692 |
| A | LEU695 |
| A | ASP711 |
| A | HOH1115 |
| A | ALA597 |
| A | LYS599 |
| A | GLU612 |
| A | ILE626 |
| A | ILE642 |
| A | GLU643 |
| A | CYS645 |
| A | ALA646 |
Functional Information from PROSITE/UniProt
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IvHrDLKphNILI |
| Chain | Residue | Details |
| A | ILE684-ILE696 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 128 |
| Details | Domain: {"description":"KEN","evidences":[{"source":"PROSITE-ProRule","id":"PRU00725","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Region: {"description":"Interacts with hydroxy-aryl-aldehyde inhibitors","evidences":[{"source":"UniProtKB","id":"Q9EQY0","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"UniProtKB","id":"P32361","evidenceCode":"ECO:0000250"},{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P32361","evidenceCode":"ECO:0000250"},{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"21317875","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9637683","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3P23","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21317875","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3P23","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Site: {"description":"Interacts with hydroxy-aryl-aldehyde inhibitors","evidences":[{"source":"UniProtKB","id":"Q9EQY0","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"30118681","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36739529","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
