6W0T

Co-crystal structures of CHIKV nsP3 macrodomain with pyrimidone fragments

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue S6Y A 201

Chain	Residue
A	ALA22
A	TYR114
A	HOH302
A	ALA23
A	CYS34
A	GLY70
A	LEU109
A	SER110
A	THR111
A	GLY112
A	VAL113

---

site_id	AC2
Number of Residues	12
Details	binding site for residue S6Y B 201

Chain	Residue
B	ALA22
B	ALA23
B	ASP31
B	CYS34
B	GLY70
B	LEU108
B	LEU109
B	SER110
B	THR111
B	GLY112
B	VAL113
B	TYR114

---

site_id	AC3
Number of Residues	12
Details	binding site for residue S6Y C 201

Chain	Residue
C	ALA22
C	ALA23
C	ASN24
C	CYS34
C	GLY70
C	LEU108
C	LEU109
C	SER110
C	THR111
C	GLY112
C	VAL113
C	TYR114

---

site_id	AC4
Number of Residues	11
Details	binding site for residue S6Y D 201

Chain	Residue
D	ALA22
D	ALA23
D	CYS34
D	GLY70
D	LEU108
D	LEU109
D	SER110
D	THR111
D	GLY112
D	VAL113
D	TYR114

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	477
Details	Domain: {"description":"Macro","evidences":[{"source":"PROSITE-ProRule","id":"PRU00490","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19386706","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---