6W0R

Human 8-oxoguanine glycosylase interrogating fully intrahelical undamaged DNA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
A	0003677	molecular_function	DNA binding
A	0003684	molecular_function	damaged DNA binding
A	0003824	molecular_function	catalytic activity
A	0004519	molecular_function	endonuclease activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0005829	cellular_component	cytosol
A	0006281	biological_process	DNA repair
A	0006284	biological_process	base-excision repair
A	0006285	biological_process	base-excision repair, AP site formation
A	0006289	biological_process	nucleotide-excision repair
A	0006355	biological_process	regulation of DNA-templated transcription
A	0006974	biological_process	DNA damage response
A	0006979	biological_process	response to oxidative stress
A	0008017	molecular_function	microtubule binding
A	0008534	molecular_function	oxidized purine nucleobase lesion DNA N-glycosylase activity
A	0009314	biological_process	response to radiation
A	0016363	cellular_component	nuclear matrix
A	0016607	cellular_component	nuclear speck
A	0016787	molecular_function	hydrolase activity
A	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
A	0016829	molecular_function	lyase activity
A	0019899	molecular_function	enzyme binding
A	0032357	molecular_function	oxidized purine DNA binding
A	0032991	cellular_component	protein-containing complex
A	0034039	molecular_function	8-oxo-7,8-dihydroguanine DNA N-glycosylase activity
A	0034614	biological_process	cellular response to reactive oxygen species
A	0044029	biological_process	positive regulation of gene expression via chromosomal CpG island demethylation
A	0045007	biological_process	depurination
A	0045008	biological_process	depyrimidination
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0140078	molecular_function	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A	1901291	biological_process	negative regulation of double-strand break repair via single-strand annealing

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue NA A 401

Chain	Residue
A	CYS241
A	LEU243
A	VAL246
B	DC26

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site_id	AC2
Number of Residues	4
Details	binding site for residue NO3 A 402

Chain	Residue
A	VAL58
A	ALA60
A	TYR99
A	ASP136

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site_id	AC3
Number of Residues	6
Details	binding site for residue NO3 A 403

Chain	Residue
A	LYS98
A	GLN101
A	LEU102
A	ASP103
A	HOH557
A	ARG97

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site_id	AC4
Number of Residues	4
Details	binding site for residue NO3 A 404

Chain	Residue
A	TYR233
A	ASP252
A	ARG304
A	HOH506

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site_id	AC5
Number of Residues	6
Details	binding site for residue S5Y B 101

Chain	Residue
A	TYR203
A	CYS207
B	DG24
B	DT25
B	DC26
C	DC7

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Schiff-base intermediate with DNA => ECO:0000269|PubMed:9197244

Chain	Residue	Details
A	LYS249

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site_id	SWS_FT_FI2
Number of Residues	5
Details	BINDING: BINDING => ECO:0000269|PubMed:10706276, ECO:0000269|PubMed:11902834, ECO:0000269|PubMed:12578369, ECO:0000269|PubMed:12592398, ECO:0000269|PubMed:15610848

Chain	Residue	Details
A	ASN149
A	ARG154
A	ARG204
A	HIS270
A	GLN287

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site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING:

Chain	Residue	Details
A	PRO266
A	ASP268
A	GLN315
A	PHE319

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	2
Details	M-CSA 185

Chain	Residue	Details
A	LYS249	covalently attached, electron pair acceptor, electron pair donor, hydrogen bond donor, nucleofuge, nucleophile, proton acceptor, proton donor
A	ASP268	electrostatic stabiliser, hydrogen bond acceptor

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