Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6VZV

TTLL6 bound to gamma-elongation analog

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0036211	biological_process	protein modification process
B	0036211	biological_process	protein modification process
C	0036211	biological_process	protein modification process
D	0036211	biological_process	protein modification process

Functional Information from PDB Data

site_id	AC1
Number of Residues	28
Details	binding site for residue S3A A 601

Chain	Residue
A	TYR69
A	LYS283
A	ASP346
A	GLU359
A	ASN361
A	HIS362
A	SER363
A	PRO364
A	SER365
A	LYS377
A	ADP602
A	CYS179
A	MG603
A	MG604
A	HOH714
A	HOH719
A	HOH721
A	HOH722
A	HOH726
A	HOH749
C	LYS194
A	GLN180
A	ARG219
A	LEU239
A	ARG241
A	ASN264
A	TYR265
A	SER266

site_id	AC2
Number of Residues	26
Details	binding site for residue ADP A 602

Chain	Residue
A	LYS125
A	ILE172
A	LYS174
A	CYS179
A	GLN180
A	GLY181
A	ILE184
A	GLN202
A	LEU203
A	TYR204
A	ILE205
A	LYS215
A	ASP217
A	LEU262
A	THR263
A	ASN264
A	ASP346
A	LEU348
A	LEU358
A	GLU359
A	S3A601
A	MG603
A	MG604
A	HOH714
A	HOH719
A	HOH754

site_id	AC3
Number of Residues	5
Details	binding site for residue MG A 603

Chain	Residue
A	GLU359
A	ASN361
A	S3A601
A	ADP602
A	HOH714

site_id	AC4
Number of Residues	6
Details	binding site for residue MG A 604

Chain	Residue
A	ASN264
A	ASP346
A	GLU359
A	S3A601
A	ADP602
A	HOH719

site_id	AC5
Number of Residues	6
Details	binding site for residue GOL A 605

Chain	Residue
A	GLY181
A	ARG182
A	GLY183
A	ILE184
A	LEU262
C	PHE185

site_id	AC6
Number of Residues	5
Details	binding site for residue GOL A 606

Chain	Residue
A	SER133
A	ARG148
A	THR149
A	TRP150
A	ASP158

site_id	AC7
Number of Residues	4
Details	binding site for residue GOL A 607

Chain	Residue
A	GLU301
A	ARG305
A	ARG445
A	HOH770

site_id	AC8
Number of Residues	5
Details	binding site for residue GOL A 608

Chain	Residue
A	TYR69
A	ASP70
A	SER367
A	THR368
A	HOH751

site_id	AC9
Number of Residues	2
Details	binding site for residue GOL A 609

Chain	Residue
A	GLN78
A	TYR382

site_id	AD1
Number of Residues	6
Details	binding site for residue GOL A 610

Chain	Residue
A	PRO208
A	PHE209
A	ILE210
A	ARG351
A	HOH709
A	HOH800

site_id	AD2
Number of Residues	8
Details	binding site for residue GOL A 611

Chain	Residue
A	SER282
A	ARG284
A	PHE214
A	ALA243
A	THR244
A	ASN273
A	SER280
A	GLY281

site_id	AD3
Number of Residues	4
Details	binding site for residue GOL A 612

Chain	Residue
A	ASP142
A	ASP309
A	LYS313
A	LYS455

site_id	AD4
Number of Residues	3
Details	binding site for residue GOL A 613

Chain	Residue
A	ASP299
A	GLN302
A	ARG305

site_id	AD5
Number of Residues	3
Details	binding site for residue GOL A 614

Chain	Residue
A	GLN78
A	ASP378
A	HOH772

site_id	AD6
Number of Residues	8
Details	binding site for residue GOL A 615

Chain	Residue
A	PRO175
A	GLY183
A	ASP198
A	MET199
A	HOH706
C	PRO175
C	GLY183
C	HOH751

site_id	AD7
Number of Residues	11
Details	binding site for residue S37 A 616

Chain	Residue
A	PRO147
A	ARG148
A	TYR162
A	LYS169
A	LEU203
A	TYR204
A	ILE205
A	SER206
A	LYS207
A	ASP350
A	TRP356

site_id	AD8
Number of Residues	26
Details	binding site for residue S3A B 601

Chain	Residue
B	CYS179
B	GLN180
B	ARG219
B	LEU239
B	ARG241
B	ASN264
B	TYR265
B	SER266
B	LYS283
B	ASP346
B	GLU359
B	ASN361
B	HIS362
B	SER363
B	PRO364
B	SER365
B	LYS377
B	ADP602
B	MG603
B	MG604
B	HOH713
B	HOH723
B	HOH724
B	HOH776
B	HOH779
D	LYS194

site_id	AD9
Number of Residues	26
Details	binding site for residue ADP B 602

Chain	Residue
B	LYS125
B	ILE172
B	LYS174
B	CYS179
B	GLN180
B	GLY181
B	ILE184
B	GLN202
B	LEU203
B	TYR204
B	ILE205
B	LYS215
B	ASP217
B	LEU262
B	THR263
B	ASN264
B	ASP346
B	LEU348
B	LEU358
B	GLU359
B	S3A601
B	MG603
B	MG604
B	HOH713
B	HOH724
B	HOH750

site_id	AE1
Number of Residues	5
Details	binding site for residue MG B 603

Chain	Residue
B	ASP346
B	GLU359
B	S3A601
B	ADP602
B	HOH713

site_id	AE2
Number of Residues	5
Details	binding site for residue MG B 604

Chain	Residue
B	GLU359
B	ASN361
B	S3A601
B	ADP602
B	HOH724

site_id	AE3
Number of Residues	5
Details	binding site for residue GOL B 605

Chain	Residue
B	GLU301
B	ARG305
B	ARG445
B	HOH707
B	HOH792

site_id	AE4
Number of Residues	6
Details	binding site for residue GOL B 606

Chain	Residue
B	ARG68
B	TYR69
B	ASP70
B	SER367
B	HOH766
B	HOH781

site_id	AE5
Number of Residues	4
Details	binding site for residue GOL B 607

Chain	Residue
B	ARG148
B	THR149
B	ASP155
B	ASP158

site_id	AE6
Number of Residues	4
Details	binding site for residue GOL B 608

Chain	Residue
B	PRO208
B	PHE209
B	ILE210
B	ARG351

site_id	AE7
Number of Residues	3
Details	binding site for residue GOL B 609

Chain	Residue
B	GLN78
B	TYR382
B	GOL610

site_id	AE8
Number of Residues	6
Details	binding site for residue GOL B 610

Chain	Residue
B	SER379
B	TYR382
B	ASP383
B	GOL609
B	HOH710
B	HOH735

site_id	AE9
Number of Residues	7
Details	binding site for residue GOL B 611

Chain	Residue
B	ALA278
B	PHE279
B	LYS285
B	THR288
B	HOH716
B	HOH718
B	HOH784

site_id	AF1
Number of Residues	3
Details	binding site for residue GOL B 612

Chain	Residue
B	LYS207
B	PRO208
B	ILE210

site_id	AF2
Number of Residues	26
Details	binding site for residue S3A C 601

Chain	Residue
A	LYS194
C	CYS179
C	GLN180
C	ARG219
C	LEU239
C	ARG241
C	ASN264
C	TYR265
C	SER266
C	LYS283
C	ASP346
C	GLU359
C	ASN361
C	HIS362
C	SER363
C	PRO364
C	SER365
C	LYS377
C	ADP602
C	MG603
C	MG604
C	HOH725
C	HOH726
C	HOH736
C	HOH768
C	HOH796

site_id	AF3
Number of Residues	25
Details	binding site for residue ADP C 602

Chain	Residue
C	LYS125
C	ILE172
C	LYS174
C	CYS179
C	GLN180
C	GLY181
C	ILE184
C	GLN202
C	LEU203
C	TYR204
C	ILE205
C	LYS215
C	ASP217
C	LEU262
C	THR263
C	ASN264
C	ASP346
C	LEU348
C	LEU358
C	GLU359
C	S3A601
C	MG603
C	MG604
C	HOH726
C	HOH769

site_id	AF4
Number of Residues	5
Details	binding site for residue MG C 603

Chain	Residue
C	GLU359
C	ASN361
C	S3A601
C	ADP602
C	HOH725

site_id	AF5
Number of Residues	5
Details	binding site for residue MG C 604

Chain	Residue
C	ASP346
C	GLU359
C	S3A601
C	ADP602
C	HOH726

site_id	AF6
Number of Residues	5
Details	binding site for residue GOL C 605

Chain	Residue
C	ARG68
C	ASP70
C	SER367
C	HOH742
C	HOH774

site_id	AF7
Number of Residues	6
Details	binding site for residue GOL C 606

Chain	Residue
A	PHE185
A	ASP256
C	GLY181
C	ARG182
C	GLY183
C	ILE184

site_id	AF8
Number of Residues	3
Details	binding site for residue GOL C 607

Chain	Residue
C	GLN78
C	ASP378
C	HOH780

site_id	AF9
Number of Residues	5
Details	binding site for residue GOL C 608

Chain	Residue
C	GLU301
C	ARG305
C	ARG445
C	HOH704
C	HOH776

site_id	AG1
Number of Residues	5
Details	binding site for residue GOL C 609

Chain	Residue
C	ARG305
C	GLU308
C	ILE447
C	ASN452
C	TYR456

site_id	AG2
Number of Residues	4
Details	binding site for residue GOL C 610

Chain	Residue
C	PHE209
C	ILE210
C	ARG351
C	HOH724

site_id	AG3
Number of Residues	28
Details	binding site for residue S3A D 601

Chain	Residue
B	LYS194
D	TYR69
D	CYS179
D	GLN180
D	ARG219
D	LEU239
D	ARG241
D	ASN264
D	TYR265
D	SER266
D	LYS283
D	ASP346
D	GLU359
D	ASN361
D	HIS362
D	SER363
D	PRO364
D	SER365
D	LYS377
D	ADP602
D	MG603
D	MG604
D	HOH709
D	HOH715
D	HOH719
D	HOH729
D	HOH739
D	HOH767

site_id	AG4
Number of Residues	26
Details	binding site for residue ADP D 602

Chain	Residue
D	LYS125
D	ILE172
D	LYS174
D	CYS179
D	GLN180
D	GLY181
D	ILE184
D	GLN202
D	LEU203
D	TYR204
D	ILE205
D	LYS215
D	ASP217
D	LEU262
D	THR263
D	ASN264
D	ASP346
D	LEU348
D	LEU358
D	GLU359
D	S3A601
D	MG603
D	MG604
D	HOH709
D	HOH739
D	HOH745

site_id	AG5
Number of Residues	5
Details	binding site for residue MG D 603

Chain	Residue
D	ASP346
D	GLU359
D	S3A601
D	ADP602
D	HOH739

site_id	AG6
Number of Residues	5
Details	binding site for residue MG D 604

Chain	Residue
D	GLU359
D	ASN361
D	S3A601
D	ADP602
D	HOH709

site_id	AG7
Number of Residues	5
Details	binding site for residue GOL D 605

Chain	Residue
D	ASN290
D	GLU301
D	ARG305
D	ARG445
D	HOH798

site_id	AG8
Number of Residues	5
Details	binding site for residue GOL D 606

Chain	Residue
D	ARG68
D	TYR69
D	ASP70
D	SER367
D	HOH764

site_id	AG9
Number of Residues	5
Details	binding site for residue GOL D 607

Chain	Residue
D	ASP142
D	ASP309
D	LYS313
D	LYS455
D	TYR456

site_id	AH1
Number of Residues	4
Details	binding site for residue GOL D 608

Chain	Residue
D	TYR265
D	PHE274
D	GLN276
D	HOH810

site_id	AH2
Number of Residues	7
Details	binding site for residue GOL D 609

Chain	Residue
B	PRO175
B	ASP198
D	PRO175
D	ASP198
D	MET199
D	HOH727
D	HOH777

site_id	AH3
Number of Residues	5
Details	binding site for residue GOL D 610

Chain	Residue
D	GLU301
D	GLN302
D	ARG305
D	HOH712
D	HOH723

site_id	AH4
Number of Residues	4
Details	binding site for residue GOL D 611

Chain	Residue
D	LYS207
D	PRO208
D	ILE210
D	TYR247

site_id	AH5
Number of Residues	11
Details	binding site for residue S37 D 612

Chain	Residue
D	PRO147
D	ARG148
D	TYR162
D	LYS169
D	LEU203
D	TYR204
D	ILE205
D	SER206
D	LYS207
D	ASP350
D	TRP356

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1029
Details	Domain: {"description":"TTL","evidences":[{"source":"PROSITE-ProRule","id":"PRU00568","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	316
Details	Region: {"description":"c-MTBD region","evidences":[{"source":"UniProtKB","id":"Q8N841","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	32
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32747782","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VZT","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32747782","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32747782","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6VZU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VZW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32747782","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VZU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	4
Details	Site: {"description":"Essential for specifying alpha-elongation versus initiation step of the polyglutamylase activity","evidences":[{"source":"PubMed","id":"32747782","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	4
Details	Site: {"description":"Important for specifying alpha-elongation versus initiation step of the polyglutamylase activity","evidences":[{"source":"PubMed","id":"32747782","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)