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6VZM

Crystal structure of human PPARgamma ligand binding domain Y473E mutant in complex with Darglitazone

Functional Information from GO Data
ChainGOidnamespacecontents
A0003677molecular_functionDNA binding
A0004879molecular_functionnuclear receptor activity
A0005634cellular_componentnucleus
A0006355biological_processregulation of DNA-templated transcription
B0003677molecular_functionDNA binding
B0004879molecular_functionnuclear receptor activity
B0005634cellular_componentnucleus
B0006355biological_processregulation of DNA-templated transcription
Functional Information from PDB Data
site_idAC1
Number of Residues12
Detailsbinding site for residue GEV A 501
ChainResidue
ALEU255
ALEU330
ALEU333
AILE341
AARG280
AILE281
AGLY284
ACYS285
AARG288
ASER289
AALA292
AILE326

site_idAC2
Number of Residues16
Detailsbinding site for residue GEV B 501
ChainResidue
BILE249
BLEU255
BGLU259
BPHE264
BHIS266
BARG280
BILE281
BCYS285
BARG288
BALA292
BILE326
BMET329
BLEU330
BLEU333
BILE341
BMET348

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG
ChainResidueDetails
AGLN286
AHIS323
AHIS449
AGLU473
BGLN286
BHIS323
BHIS449
BGLU473

site_idSWS_FT_FI2
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36737649
ChainResidueDetails
ALYS224
BLYS224

226707

PDB entries from 2024-10-30

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