6VXO

NaChBac-Nav1.7VSDII chimera in nanodisc

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0005261	molecular_function	monoatomic cation channel activity
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0055085	biological_process	transmembrane transport
C	0005216	molecular_function	monoatomic ion channel activity
C	0005261	molecular_function	monoatomic cation channel activity
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0055085	biological_process	transmembrane transport
D	0005216	molecular_function	monoatomic ion channel activity
D	0005261	molecular_function	monoatomic cation channel activity
D	0005886	cellular_component	plasma membrane
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0055085	biological_process	transmembrane transport
E	0005216	molecular_function	monoatomic ion channel activity
E	0005261	molecular_function	monoatomic cation channel activity
E	0005886	cellular_component	plasma membrane
E	0006811	biological_process	monoatomic ion transport
E	0016020	cellular_component	membrane
E	0055085	biological_process	transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue POV A 301

Chain	Residue
A	LEU34
A	TYR45
A	ARG47
D	POV301
E	LEU180

---

site_id	AC2
Number of Residues	10
Details	binding site for residue POV A 302

Chain	Residue
A	TRP212
C	GLN181
C	LEU182
C	LEU184
C	LEU185
D	POV303
A	PHE205
A	ALA206
A	PRO209
A	TRP210

---

site_id	AC3
Number of Residues	8
Details	binding site for residue POV A 303

Chain	Residue
A	PHE157
A	PHE161
A	GLU207
A	VAL208
A	PRO209
A	TRP210
C	SER113
C	VAL114

---

site_id	AC4
Number of Residues	5
Details	binding site for residue POV C 301

Chain	Residue
A	LEU180
C	LEU34
C	TYR45
C	ARG47
E	POV301

---

site_id	AC5
Number of Residues	8
Details	binding site for residue POV C 302

Chain	Residue
C	PHE157
C	PHE161
C	GLU207
C	VAL208
C	PRO209
C	TRP210
D	SER113
D	VAL114

---

site_id	AC6
Number of Residues	10
Details	binding site for residue POV D 301

Chain	Residue
A	POV301
D	PHE205
D	ALA206
D	PRO209
D	TRP210
D	TRP212
E	GLN181
E	LEU182
E	LEU184
E	LEU185

---

site_id	AC7
Number of Residues	9
Details	binding site for residue POV D 302

Chain	Residue
D	LEU153
D	PHE157
D	PHE161
D	GLU207
D	VAL208
D	PRO209
D	TRP210
E	SER113
E	VAL114

---

site_id	AC8
Number of Residues	5
Details	binding site for residue POV D 303

Chain	Residue
A	POV302
C	LEU180
D	LEU34
D	TYR45
D	ARG47

---

site_id	AC9
Number of Residues	10
Details	binding site for residue POV D 304

Chain	Residue
C	PHE205
C	ALA206
C	PRO209
C	TRP210
C	TRP212
D	GLN181
D	LEU182
D	LEU184
D	LEU185
E	POV303

---

site_id	AD1
Number of Residues	10
Details	binding site for residue POV E 301

Chain	Residue
A	GLN181
A	LEU182
A	LEU184
A	LEU185
C	POV301
E	PHE205
E	ALA206
E	PRO209
E	TRP210
E	TRP212

---

site_id	AD2
Number of Residues	9
Details	binding site for residue POV E 302

Chain	Residue
A	SER113
A	VAL114
E	LEU153
E	PHE157
E	PHE161
E	GLU207
E	VAL208
E	PRO209
E	TRP210

---

site_id	AD3
Number of Residues	5
Details	binding site for residue POV E 303

Chain	Residue
D	LEU180
D	POV304
E	LEU34
E	TYR45
E	ARG47

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	TOPO_DOM: Extracellular => ECO:0000305

Chain	Residue	Details
A	GLU110-GLY111
C	GLU110-GLY111
D	GLU110-GLY111
E	GLU110-GLY111

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	SITE: Is directly targeted by the spider protoxin-II => ECO:0000269|PubMed:30661758

Chain	Residue	Details
A	GLU103
A	ASP108
C	GLU103
C	ASP108
D	GLU103
D	ASP108
E	GLU103
E	ASP108

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