6VX6

bestrophin-2 Ca2+-bound state (250 nM Ca2+)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005254	molecular_function	chloride channel activity
B	0005254	molecular_function	chloride channel activity
C	0005254	molecular_function	chloride channel activity
D	0005254	molecular_function	chloride channel activity
E	0005254	molecular_function	chloride channel activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue CA E 501

Chain	Residue
D	ALA10
E	GLN293
E	ASN296
E	ASP301
E	ASP304

---

site_id	AC2
Number of Residues	5
Details	binding site for residue CA A 502

Chain	Residue
E	ALA10
A	GLN293
A	ASN296
A	ASP301
A	ASP304

---

site_id	AC3
Number of Residues	5
Details	binding site for residue CA B 501

Chain	Residue
A	ALA10
B	GLN293
B	ASN296
B	ASP301
B	ASP304

---

site_id	AC4
Number of Residues	5
Details	binding site for residue CA C 501

Chain	Residue
B	ALA10
C	GLN293
C	ASN296
C	ASP301
C	ASP304

---

site_id	AC5
Number of Residues	5
Details	binding site for residue CA D 501

Chain	Residue
C	ALA10
D	GLN293
D	ASN296
D	ASP301
D	ASP304

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	345
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"32251414","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35789156","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36289327","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VX5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VX6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VX7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VX8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VX9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8D1N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ECY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	130
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	775
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	5
Details	Binding site: {"description":"in other chain","evidences":[{"source":"PubMed","id":"32251414","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35789156","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36289327","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VX5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VX6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VX7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VX8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VX9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8D1N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ECY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32251414","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35789156","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36289327","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VX5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VX6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VX7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VX8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VX9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8D1N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ECY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---