6VX5

bestrophin-2 Ca2+- unbound state (250 nM Ca2+)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005254	molecular_function	chloride channel activity
B	0005254	molecular_function	chloride channel activity
C	0005254	molecular_function	chloride channel activity
D	0005254	molecular_function	chloride channel activity
E	0005254	molecular_function	chloride channel activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	345
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"32251414","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35789156","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36289327","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VX5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VX6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VX7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VX8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VX9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8D1N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ECY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	130
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	775
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32251414","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35789156","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36289327","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VX5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VX6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VX7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VX8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VX9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8D1N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ECY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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