Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6VWK

E. coli ATP Synthase ADP Sub-state 3a Fo Focussed

Functional Information from GO Data

Chain	GOid	namespace	contents
a	0005886	cellular_component	plasma membrane
a	0006754	biological_process	ATP biosynthetic process
a	0006811	biological_process	monoatomic ion transport
a	0015078	molecular_function	proton transmembrane transporter activity
a	0015986	biological_process	proton motive force-driven ATP synthesis
a	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
a	0045259	cellular_component	proton-transporting ATP synthase complex
a	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
a	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
a	1902600	biological_process	proton transmembrane transport
I	0005886	cellular_component	plasma membrane
I	0006754	biological_process	ATP biosynthetic process
I	0006811	biological_process	monoatomic ion transport
I	0008289	molecular_function	lipid binding
I	0015078	molecular_function	proton transmembrane transporter activity
I	0015986	biological_process	proton motive force-driven ATP synthesis
I	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
I	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
I	0045259	cellular_component	proton-transporting ATP synthase complex
I	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
I	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
I	1902600	biological_process	proton transmembrane transport
J	0005886	cellular_component	plasma membrane
J	0006754	biological_process	ATP biosynthetic process
J	0006811	biological_process	monoatomic ion transport
J	0008289	molecular_function	lipid binding
J	0015078	molecular_function	proton transmembrane transporter activity
J	0015986	biological_process	proton motive force-driven ATP synthesis
J	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
J	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
J	0045259	cellular_component	proton-transporting ATP synthase complex
J	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
J	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
J	1902600	biological_process	proton transmembrane transport
L	0005886	cellular_component	plasma membrane
L	0006754	biological_process	ATP biosynthetic process
L	0006811	biological_process	monoatomic ion transport
L	0008289	molecular_function	lipid binding
L	0015078	molecular_function	proton transmembrane transporter activity
L	0015986	biological_process	proton motive force-driven ATP synthesis
L	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
L	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
L	0045259	cellular_component	proton-transporting ATP synthase complex
L	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
L	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
L	1902600	biological_process	proton transmembrane transport
M	0005886	cellular_component	plasma membrane
M	0006754	biological_process	ATP biosynthetic process
M	0006811	biological_process	monoatomic ion transport
M	0008289	molecular_function	lipid binding
M	0015078	molecular_function	proton transmembrane transporter activity
M	0015986	biological_process	proton motive force-driven ATP synthesis
M	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
M	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
M	0045259	cellular_component	proton-transporting ATP synthase complex
M	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
M	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
M	1902600	biological_process	proton transmembrane transport
N	0005886	cellular_component	plasma membrane
N	0006754	biological_process	ATP biosynthetic process
N	0006811	biological_process	monoatomic ion transport
N	0008289	molecular_function	lipid binding
N	0015078	molecular_function	proton transmembrane transporter activity
N	0015986	biological_process	proton motive force-driven ATP synthesis
N	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
N	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
N	0045259	cellular_component	proton-transporting ATP synthase complex
N	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
N	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
N	1902600	biological_process	proton transmembrane transport
O	0005886	cellular_component	plasma membrane
O	0006754	biological_process	ATP biosynthetic process
O	0006811	biological_process	monoatomic ion transport
O	0008289	molecular_function	lipid binding
O	0015078	molecular_function	proton transmembrane transporter activity
O	0015986	biological_process	proton motive force-driven ATP synthesis
O	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
O	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
O	0045259	cellular_component	proton-transporting ATP synthase complex
O	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
O	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
O	1902600	biological_process	proton transmembrane transport
P	0005886	cellular_component	plasma membrane
P	0006754	biological_process	ATP biosynthetic process
P	0006811	biological_process	monoatomic ion transport
P	0008289	molecular_function	lipid binding
P	0015078	molecular_function	proton transmembrane transporter activity
P	0015986	biological_process	proton motive force-driven ATP synthesis
P	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
P	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
P	0045259	cellular_component	proton-transporting ATP synthase complex
P	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
P	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
P	1902600	biological_process	proton transmembrane transport
Q	0005886	cellular_component	plasma membrane
Q	0006754	biological_process	ATP biosynthetic process
Q	0006811	biological_process	monoatomic ion transport
Q	0008289	molecular_function	lipid binding
Q	0015078	molecular_function	proton transmembrane transporter activity
Q	0015986	biological_process	proton motive force-driven ATP synthesis
Q	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
Q	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
Q	0045259	cellular_component	proton-transporting ATP synthase complex
Q	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
Q	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
Q	1902600	biological_process	proton transmembrane transport
R	0005886	cellular_component	plasma membrane
R	0006754	biological_process	ATP biosynthetic process
R	0006811	biological_process	monoatomic ion transport
R	0008289	molecular_function	lipid binding
R	0015078	molecular_function	proton transmembrane transporter activity
R	0015986	biological_process	proton motive force-driven ATP synthesis
R	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
R	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
R	0045259	cellular_component	proton-transporting ATP synthase complex
R	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
R	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
R	1902600	biological_process	proton transmembrane transport
S	0005886	cellular_component	plasma membrane
S	0006754	biological_process	ATP biosynthetic process
S	0006811	biological_process	monoatomic ion transport
S	0008289	molecular_function	lipid binding
S	0015078	molecular_function	proton transmembrane transporter activity
S	0015986	biological_process	proton motive force-driven ATP synthesis
S	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
S	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
S	0045259	cellular_component	proton-transporting ATP synthase complex
S	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
S	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
S	1902600	biological_process	proton transmembrane transport
X	0005886	cellular_component	plasma membrane
X	0006754	biological_process	ATP biosynthetic process
X	0006811	biological_process	monoatomic ion transport
X	0015078	molecular_function	proton transmembrane transporter activity
X	0015986	biological_process	proton motive force-driven ATP synthesis
X	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
X	0045259	cellular_component	proton-transporting ATP synthase complex
X	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
X	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
X	1902600	biological_process	proton transmembrane transport
Y	0005886	cellular_component	plasma membrane
Y	0006754	biological_process	ATP biosynthetic process
Y	0006811	biological_process	monoatomic ion transport
Y	0015078	molecular_function	proton transmembrane transporter activity
Y	0015986	biological_process	proton motive force-driven ATP synthesis
Y	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
Y	0045259	cellular_component	proton-transporting ATP synthase complex
Y	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
Y	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
Y	1902600	biological_process	proton transmembrane transport

Functional Information from PROSITE/UniProt

site_id	PS00449
Number of Residues	10
Details	ATPASE_A ATP synthase a subunit signature. SLGLRLFGNM

Chain	Residue	Details
a	SER206-MET215

site_id	PS00605
Number of Residues	22
Details	ATPASE_C ATP synthase c subunit signature. ARQPdliplLrTqfFIvmgLvD

Chain	Residue	Details
I	ALA40-ASP61

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	400
Details	Transmembrane: {"description":"Helical"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	200
Details	Topological domain: {"description":"Cytoplasmic"}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	50
Details	Topological domain: {"description":"Periplasmic"}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	10
Details	Site: {"description":"Reversibly protonated during proton transport"}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	40
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"HAMAP-Rule","id":"MF_01398","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	2
Details	Site: {"description":"Mutation prevents the formation of a functional proton pore, but has a small effect on the binding of F(1) to F(0)"}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	100
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	90
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	25
Details	Topological domain: {"description":"Periplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	3
Details	M-CSA 507

Chain

Residue

Details

site_id	MCSA10
Number of Residues	1
Details	M-CSA 507

Chain	Residue	Details
J	ASP61	electrostatic stabiliser, proton acceptor, proton donor

site_id	MCSA2
Number of Residues	1
Details	M-CSA 507

Chain

Residue

Details

site_id	MCSA3
Number of Residues	1
Details	M-CSA 507

Chain

Residue

Details

site_id	MCSA4
Number of Residues	1
Details	M-CSA 507

Chain

Residue

Details

site_id	MCSA5
Number of Residues	1
Details	M-CSA 507

Chain

Residue

Details

site_id	MCSA6
Number of Residues	1
Details	M-CSA 507

Chain

Residue

Details

site_id	MCSA7
Number of Residues	1
Details	M-CSA 507

Chain

Residue

Details

site_id	MCSA8
Number of Residues	1
Details	M-CSA 507

Chain

Residue

Details

site_id	MCSA9
Number of Residues	1
Details	M-CSA 507

Chain	Residue	Details
I	ASP61	electrostatic stabiliser, proton acceptor, proton donor

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)