6VUW
Crystal structure of Eis from Mycobacterium tuberculosis in complex with inhibitor SGT368
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005829 | cellular_component | cytosol |
| A | 0008080 | molecular_function | N-acetyltransferase activity |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| A | 0030649 | biological_process | aminoglycoside antibiotic catabolic process |
| A | 0033661 | biological_process | effector-mediated defense to host-produced reactive oxygen species |
| A | 0034054 | biological_process | symbiont-mediated suppression of host defense-related programmed cell death |
| A | 0034069 | molecular_function | aminoglycoside N-acetyltransferase activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0043655 | cellular_component | host extracellular space |
| A | 0044161 | cellular_component | host cell cytoplasmic vesicle |
| A | 0046677 | biological_process | response to antibiotic |
| A | 0051701 | biological_process | biological process involved in interaction with host |
| A | 0052032 | biological_process | symbiont-mediated perturbation of host inflammatory response |
| A | 0052040 | biological_process | symbiont-mediated perturbation of host programmed cell death |
| A | 0052167 | biological_process | symbiont-mediated perturbation of host innate immune response |
| A | 0061733 | molecular_function | peptide-lysine-N-acetyltransferase activity |
| A | 0097691 | cellular_component | bacterial extracellular vesicle |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | binding site for residue RNM A 501 |
| Chain | Residue |
| A | TRP13 |
| A | ASP26 |
| A | ALA33 |
| A | TRP36 |
| A | LEU63 |
| A | SER83 |
| A | PHE84 |
| A | GLU401 |
| A | PHE402 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 502 |
| Chain | Residue |
| A | TRP182 |
| A | LEU241 |
| A | ALA243 |
| A | HIS270 |
| A | PRO274 |
| A | GLN397 |
| A | HOH626 |
| A | HOH641 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 503 |
| Chain | Residue |
| A | HIS105 |
| A | ALA109 |
| A | ARG297 |
| A | MET299 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 A 504 |
| Chain | Residue |
| A | ARG242 |
| A | ILE268 |
| A | THR269 |
| A | HIS270 |
| A | GLN397 |
| A | THR398 |
| A | NA507 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 505 |
| Chain | Residue |
| A | ARG37 |
| A | VAL40 |
| A | PRO41 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 506 |
| Chain | Residue |
| A | PRO72 |
| A | ARG308 |
| A | GLY309 |
| A | ALA391 |
| A | SER392 |
| A | ASP393 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue NA A 507 |
| Chain | Residue |
| A | THR136 |
| A | HIS270 |
| A | GLN397 |
| A | THR398 |
| A | SO4504 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton donor => ECO:0000305|PubMed:21628583 |
| Chain | Residue | Details |
| A | TYR126 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton acceptor; via carboxylate => ECO:0000305|PubMed:21628583 |
| Chain | Residue | Details |
| A | PHE402 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22547814, ECO:0000305|PubMed:21628583, ECO:0007744|PDB:3RYO |
| Chain | Residue | Details |
| A | VAL85 | |
| A | SER121 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22547814, ECO:0000305|PubMed:21628583, ECO:0000305|PubMed:24106131, ECO:0000305|PubMed:27010218, ECO:0007744|PDB:3RYO |
| Chain | Residue | Details |
| A | ARG93 |
