6VUT
Crystal structure of Eis from Mycobacterium tuberculosis in complex with inhibitor SGT392
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005829 | cellular_component | cytosol |
| A | 0008080 | molecular_function | N-acetyltransferase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| A | 0030649 | biological_process | aminoglycoside antibiotic catabolic process |
| A | 0033661 | biological_process | effector-mediated defense to host-produced reactive oxygen species |
| A | 0034069 | molecular_function | aminoglycoside N-acetyltransferase activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0043655 | cellular_component | host extracellular space |
| A | 0044161 | cellular_component | host cell cytoplasmic vesicle |
| A | 0046677 | biological_process | response to antibiotic |
| A | 0051701 | biological_process | biological process involved in interaction with host |
| A | 0052032 | biological_process | symbiont-mediated perturbation of host inflammatory response |
| A | 0052040 | biological_process | symbiont-mediated perturbation of host programmed cell death |
| A | 0052041 | biological_process | symbiont-mediated suppression of host programmed cell death |
| A | 0052167 | biological_process | symbiont-mediated perturbation of host innate immune response |
| A | 0061733 | molecular_function | protein-lysine-acetyltransferase activity |
| A | 0097691 | cellular_component | bacterial extracellular vesicle |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | binding site for residue RN7 A 501 |
| Chain | Residue |
| A | ASP26 |
| A | PEG502 |
| A | HOH662 |
| A | ILE28 |
| A | ALA33 |
| A | TRP36 |
| A | MET65 |
| A | SER83 |
| A | PHE84 |
| A | GLU401 |
| A | PHE402 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue PEG A 502 |
| Chain | Residue |
| A | HIS119 |
| A | ALA120 |
| A | GLU401 |
| A | PHE402 |
| A | RN7501 |
| A | HOH622 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | binding site for residue PEG A 503 |
| Chain | Residue |
| A | LEU241 |
| A | ARG242 |
| A | ILE267 |
| A | ILE268 |
| A | THR269 |
| A | HIS270 |
| A | GLN397 |
| A | SO4505 |
| A | NA509 |
| A | HOH657 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 504 |
| Chain | Residue |
| A | HIS105 |
| A | ARG297 |
| A | ARG353 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 A 505 |
| Chain | Residue |
| A | ARG242 |
| A | ILE268 |
| A | THR269 |
| A | HIS270 |
| A | GLN397 |
| A | THR398 |
| A | PEG503 |
| A | HOH601 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 506 |
| Chain | Residue |
| A | TRP13 |
| A | VAL40 |
| A | PRO41 |
| A | ALA45 |
| A | HOH604 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 507 |
| Chain | Residue |
| A | GLY73 |
| A | GLY309 |
| A | TYR310 |
| A | SER392 |
| A | ASP393 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue NA A 508 |
| Chain | Residue |
| A | ARG68 |
| A | THR70 |
| A | ARG183 |
| A | GLY189 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue NA A 509 |
| Chain | Residue |
| A | HIS249 |
| A | TRP253 |
| A | ILE267 |
| A | THR269 |
| A | ASP273 |
| A | PEG503 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue NA A 510 |
| Chain | Residue |
| A | GLY130 |
| A | LEU296 |
| A | ARG297 |
| A | ILE298 |
| A | ARG353 |
| A | GLY357 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"21628583","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor; via carboxylate","evidences":[{"source":"PubMed","id":"21628583","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22547814","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21628583","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3RYO","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22547814","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21628583","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"24106131","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27010218","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3RYO","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
