6VUJ

Crystal structure of BRD4 bromodomain 1 with N-methylpyrrolidin-2-one (NMP) derivative 15c (N,N-diethyl-3',4'-dimethoxy-6-(1-methyl-5-oxopyrrolidin-3-yl)-[1,1'-biphenyl]-3-sulfonamide)

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue NO3 A 201

Chain	Residue
A	ARG68
A	LYS72
A	GLN127
A	ASN130
A	THR134

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site_id	AC2
Number of Residues	14
Details	binding site for residue RLY A 202

Chain	Residue
A	ASP88
A	LEU92
A	LEU94
A	TYR97
A	CYS136
A	ASN140
A	ILE146
A	LYS155
A	HOH331
A	HOH361
A	PRO82
A	GLN85
A	PRO86
A	VAL87

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Functional Information from PROSITE/UniProt

site_id	PS00633
Number of Residues	60
Details	BROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY

Chain	Residue	Details
A	ALA80-TYR139

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	SITE: Acetylated histone binding => ECO:0000269|PubMed:22464331

Chain	Residue	Details
A	ASN140

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site_id	SWS_FT_FI2
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
A	LYS99

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