6VST
Arginase from Medicago truncatula in complex with ornithine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000050 | biological_process | urea cycle |
| A | 0004053 | molecular_function | arginase activity |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0008783 | molecular_function | agmatinase activity |
| A | 0016813 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines |
| A | 0033388 | biological_process | putrescine biosynthetic process from arginine |
| A | 0034214 | biological_process | protein hexamerization |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000050 | biological_process | urea cycle |
| B | 0004053 | molecular_function | arginase activity |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0008783 | molecular_function | agmatinase activity |
| B | 0016813 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines |
| B | 0033388 | biological_process | putrescine biosynthetic process from arginine |
| B | 0034214 | biological_process | protein hexamerization |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0000050 | biological_process | urea cycle |
| C | 0004053 | molecular_function | arginase activity |
| C | 0005739 | cellular_component | mitochondrion |
| C | 0008783 | molecular_function | agmatinase activity |
| C | 0016813 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines |
| C | 0033388 | biological_process | putrescine biosynthetic process from arginine |
| C | 0034214 | biological_process | protein hexamerization |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0000050 | biological_process | urea cycle |
| D | 0004053 | molecular_function | arginase activity |
| D | 0005739 | cellular_component | mitochondrion |
| D | 0008783 | molecular_function | agmatinase activity |
| D | 0016813 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines |
| D | 0033388 | biological_process | putrescine biosynthetic process from arginine |
| D | 0034214 | biological_process | protein hexamerization |
| D | 0046872 | molecular_function | metal ion binding |
| E | 0000050 | biological_process | urea cycle |
| E | 0004053 | molecular_function | arginase activity |
| E | 0005739 | cellular_component | mitochondrion |
| E | 0008783 | molecular_function | agmatinase activity |
| E | 0016813 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines |
| E | 0033388 | biological_process | putrescine biosynthetic process from arginine |
| E | 0034214 | biological_process | protein hexamerization |
| E | 0046872 | molecular_function | metal ion binding |
| F | 0000050 | biological_process | urea cycle |
| F | 0004053 | molecular_function | arginase activity |
| F | 0005739 | cellular_component | mitochondrion |
| F | 0008783 | molecular_function | agmatinase activity |
| F | 0016813 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines |
| F | 0033388 | biological_process | putrescine biosynthetic process from arginine |
| F | 0034214 | biological_process | protein hexamerization |
| F | 0046872 | molecular_function | metal ion binding |
| G | 0000050 | biological_process | urea cycle |
| G | 0004053 | molecular_function | arginase activity |
| G | 0005739 | cellular_component | mitochondrion |
| G | 0008783 | molecular_function | agmatinase activity |
| G | 0016813 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines |
| G | 0033388 | biological_process | putrescine biosynthetic process from arginine |
| G | 0034214 | biological_process | protein hexamerization |
| G | 0046872 | molecular_function | metal ion binding |
| H | 0000050 | biological_process | urea cycle |
| H | 0004053 | molecular_function | arginase activity |
| H | 0005739 | cellular_component | mitochondrion |
| H | 0008783 | molecular_function | agmatinase activity |
| H | 0016813 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines |
| H | 0033388 | biological_process | putrescine biosynthetic process from arginine |
| H | 0034214 | biological_process | protein hexamerization |
| H | 0046872 | molecular_function | metal ion binding |
| I | 0000050 | biological_process | urea cycle |
| I | 0004053 | molecular_function | arginase activity |
| I | 0005739 | cellular_component | mitochondrion |
| I | 0008783 | molecular_function | agmatinase activity |
| I | 0016813 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines |
| I | 0033388 | biological_process | putrescine biosynthetic process from arginine |
| I | 0034214 | biological_process | protein hexamerization |
| I | 0046872 | molecular_function | metal ion binding |
| J | 0000050 | biological_process | urea cycle |
| J | 0004053 | molecular_function | arginase activity |
| J | 0005739 | cellular_component | mitochondrion |
| J | 0008783 | molecular_function | agmatinase activity |
| J | 0016813 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines |
| J | 0033388 | biological_process | putrescine biosynthetic process from arginine |
| J | 0034214 | biological_process | protein hexamerization |
| J | 0046872 | molecular_function | metal ion binding |
| K | 0000050 | biological_process | urea cycle |
| K | 0004053 | molecular_function | arginase activity |
| K | 0005739 | cellular_component | mitochondrion |
| K | 0008783 | molecular_function | agmatinase activity |
| K | 0016813 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines |
| K | 0033388 | biological_process | putrescine biosynthetic process from arginine |
| K | 0034214 | biological_process | protein hexamerization |
| K | 0046872 | molecular_function | metal ion binding |
| L | 0000050 | biological_process | urea cycle |
| L | 0004053 | molecular_function | arginase activity |
| L | 0005739 | cellular_component | mitochondrion |
| L | 0008783 | molecular_function | agmatinase activity |
| L | 0016813 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines |
| L | 0033388 | biological_process | putrescine biosynthetic process from arginine |
| L | 0034214 | biological_process | protein hexamerization |
| L | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue MN A 401 |
| Chain | Residue |
| A | ASP181 |
| A | HIS183 |
| A | ASP266 |
| A | ASP268 |
| A | MN402 |
| A | HOH502 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue MN A 402 |
| Chain | Residue |
| A | ASP266 |
| A | MN401 |
| A | HOH502 |
| A | HIS157 |
| A | ASP181 |
| A | ASP185 |
| site_id | AC3 |
| Number of Residues | 12 |
| Details | binding site for residue ORN A 403 |
| Chain | Residue |
| A | HIS183 |
| A | ASP185 |
| A | TYR187 |
| A | HIS197 |
| A | HIS280 |
| A | HOH502 |
| A | HOH503 |
| A | HOH520 |
| A | HOH560 |
| A | HOH591 |
| B | SER93 |
| B | ASN95 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue MN B 401 |
| Chain | Residue |
| B | ASP181 |
| B | HIS183 |
| B | ASP266 |
| B | ASP268 |
| B | MN402 |
| B | HOH501 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue MN B 402 |
| Chain | Residue |
| B | HIS157 |
| B | ASP181 |
| B | ASP185 |
| B | ASP266 |
| B | MN401 |
| B | HOH501 |
| site_id | AC6 |
| Number of Residues | 13 |
| Details | binding site for residue ORN B 403 |
| Chain | Residue |
| B | HIS183 |
| B | ASP185 |
| B | TYR187 |
| B | HIS197 |
| B | HIS280 |
| B | HOH501 |
| B | HOH523 |
| B | HOH578 |
| B | HOH579 |
| B | HOH595 |
| B | HOH599 |
| C | SER93 |
| C | ASN95 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue MN C 401 |
| Chain | Residue |
| C | ASP181 |
| C | HIS183 |
| C | ASP266 |
| C | ASP268 |
| C | MN402 |
| C | HOH509 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue MN C 402 |
| Chain | Residue |
| C | HIS157 |
| C | ASP181 |
| C | ASP185 |
| C | ASP266 |
| C | MN401 |
| C | HOH509 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue MN D 401 |
| Chain | Residue |
| D | ASP181 |
| D | HIS183 |
| D | ASP266 |
| D | ASP268 |
| D | MN402 |
| D | HOH552 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue MN D 402 |
| Chain | Residue |
| D | HIS157 |
| D | ASP181 |
| D | ASP185 |
| D | ASP266 |
| D | MN401 |
| D | HOH552 |
| site_id | AD2 |
| Number of Residues | 11 |
| Details | binding site for residue ORN D 403 |
| Chain | Residue |
| D | SER93 |
| D | ASN95 |
| D | HOH502 |
| D | HOH520 |
| D | HOH548 |
| D | HOH554 |
| E | HIS183 |
| E | ASP185 |
| E | TYR187 |
| E | HIS197 |
| E | HIS280 |
| site_id | AD3 |
| Number of Residues | 6 |
| Details | binding site for residue MN E 401 |
| Chain | Residue |
| D | HOH502 |
| E | ASP181 |
| E | HIS183 |
| E | ASP266 |
| E | ASP268 |
| E | MN402 |
| site_id | AD4 |
| Number of Residues | 6 |
| Details | binding site for residue MN E 402 |
| Chain | Residue |
| D | HOH502 |
| E | HIS157 |
| E | ASP181 |
| E | ASP185 |
| E | ASP266 |
| E | MN401 |
| site_id | AD5 |
| Number of Residues | 6 |
| Details | binding site for residue MN F 401 |
| Chain | Residue |
| F | ASP268 |
| F | MN402 |
| F | HOH507 |
| F | ASP181 |
| F | HIS183 |
| F | ASP266 |
| site_id | AD6 |
| Number of Residues | 6 |
| Details | binding site for residue MN F 402 |
| Chain | Residue |
| F | HIS157 |
| F | ASP181 |
| F | ASP185 |
| F | ASP266 |
| F | MN401 |
| F | HOH507 |
| site_id | AD7 |
| Number of Residues | 13 |
| Details | binding site for residue ORN F 403 |
| Chain | Residue |
| E | SER93 |
| E | ASN95 |
| F | HIS183 |
| F | ASP185 |
| F | TYR187 |
| F | HIS197 |
| F | HIS280 |
| F | HOH507 |
| F | HOH527 |
| F | HOH556 |
| F | HOH567 |
| F | HOH577 |
| F | HOH589 |
| site_id | AD8 |
| Number of Residues | 6 |
| Details | binding site for residue MN G 401 |
| Chain | Residue |
| G | ASP181 |
| G | HIS183 |
| G | ASP266 |
| G | ASP268 |
| G | MN402 |
| G | HOH553 |
| site_id | AD9 |
| Number of Residues | 6 |
| Details | binding site for residue MN G 402 |
| Chain | Residue |
| G | HIS157 |
| G | ASP181 |
| G | ASP185 |
| G | ASP266 |
| G | MN401 |
| G | HOH553 |
| site_id | AE1 |
| Number of Residues | 6 |
| Details | binding site for residue MN H 401 |
| Chain | Residue |
| H | ASP181 |
| H | HIS183 |
| H | ASP266 |
| H | ASP268 |
| H | MN402 |
| H | HOH505 |
| site_id | AE2 |
| Number of Residues | 6 |
| Details | binding site for residue MN H 402 |
| Chain | Residue |
| H | HIS157 |
| H | ASP181 |
| H | ASP185 |
| H | ASP266 |
| H | MN401 |
| H | HOH505 |
| site_id | AE3 |
| Number of Residues | 9 |
| Details | binding site for residue ORN H 403 |
| Chain | Residue |
| H | HIS183 |
| H | ASP185 |
| H | TYR187 |
| H | HIS197 |
| H | HIS280 |
| H | HOH505 |
| H | HOH512 |
| I | SER93 |
| I | ASN95 |
| site_id | AE4 |
| Number of Residues | 6 |
| Details | binding site for residue MN I 401 |
| Chain | Residue |
| I | ASP181 |
| I | HIS183 |
| I | ASP266 |
| I | ASP268 |
| I | MN402 |
| I | HOH502 |
| site_id | AE5 |
| Number of Residues | 6 |
| Details | binding site for residue MN I 402 |
| Chain | Residue |
| I | HIS157 |
| I | ASP181 |
| I | ASP185 |
| I | ASP266 |
| I | MN401 |
| I | HOH502 |
| site_id | AE6 |
| Number of Residues | 6 |
| Details | binding site for residue MN J 401 |
| Chain | Residue |
| J | ASP181 |
| J | HIS183 |
| J | ASP266 |
| J | ASP268 |
| J | MN402 |
| J | HOH502 |
| site_id | AE7 |
| Number of Residues | 6 |
| Details | binding site for residue MN J 402 |
| Chain | Residue |
| J | HIS157 |
| J | ASP181 |
| J | ASP185 |
| J | ASP266 |
| J | MN401 |
| J | HOH502 |
| site_id | AE8 |
| Number of Residues | 12 |
| Details | binding site for residue ORN J 403 |
| Chain | Residue |
| J | HIS183 |
| J | ASP185 |
| J | TYR187 |
| J | HIS197 |
| J | HOH502 |
| J | HOH505 |
| J | HOH569 |
| J | HOH572 |
| J | HOH598 |
| L | SER93 |
| L | ASN95 |
| L | HOH545 |
| site_id | AE9 |
| Number of Residues | 6 |
| Details | binding site for residue MN K 401 |
| Chain | Residue |
| K | ASP181 |
| K | HIS183 |
| K | ASP266 |
| K | ASP268 |
| K | MN402 |
| K | HOH503 |
| site_id | AF1 |
| Number of Residues | 6 |
| Details | binding site for residue MN K 402 |
| Chain | Residue |
| K | HIS157 |
| K | ASP181 |
| K | ASP185 |
| K | ASP266 |
| K | MN401 |
| K | HOH503 |
| site_id | AF2 |
| Number of Residues | 6 |
| Details | binding site for residue MN L 401 |
| Chain | Residue |
| L | ASP181 |
| L | HIS183 |
| L | ASP266 |
| L | ASP268 |
| L | MN402 |
| L | HOH502 |
| site_id | AF3 |
| Number of Residues | 6 |
| Details | binding site for residue MN L 402 |
| Chain | Residue |
| L | HIS157 |
| L | ASP181 |
| L | ASP185 |
| L | ASP266 |
| L | MN401 |
| L | HOH502 |
| site_id | AF4 |
| Number of Residues | 12 |
| Details | binding site for residue ORN L 403 |
| Chain | Residue |
| K | SER93 |
| K | ASN95 |
| L | HIS183 |
| L | ASP185 |
| L | TYR187 |
| L | HIS197 |
| L | HIS280 |
| L | HOH502 |
| L | HOH503 |
| L | HOH510 |
| L | HOH538 |
| L | HOH573 |
Functional Information from PROSITE/UniProt
| site_id | PS01053 |
| Number of Residues | 22 |
| Details | ARGINASE_1 Arginase family signature. SIDVDsldPsiaPGvshhepgG |
| Chain | Residue | Details |
| A | SER264-GLY285 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 84 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"32754173","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 72 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00742","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"32754173","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 24 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P53608","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"32754173","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
