Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6VSS

Arginase from Medicago truncatula

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000050	biological_process	urea cycle
A	0004053	molecular_function	arginase activity
A	0005739	cellular_component	mitochondrion
A	0006525	biological_process	arginine metabolic process
A	0008783	molecular_function	agmatinase activity
A	0009446	biological_process	putrescine biosynthetic process
A	0016787	molecular_function	hydrolase activity
A	0016813	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
A	0019547	biological_process	arginine catabolic process to ornithine
A	0033388	biological_process	putrescine biosynthetic process from arginine
A	0033389	biological_process	putrescine biosynthetic process from arginine, using agmatinase
A	0034214	biological_process	protein hexamerization
A	0046872	molecular_function	metal ion binding
B	0000050	biological_process	urea cycle
B	0004053	molecular_function	arginase activity
B	0005739	cellular_component	mitochondrion
B	0006525	biological_process	arginine metabolic process
B	0008783	molecular_function	agmatinase activity
B	0009446	biological_process	putrescine biosynthetic process
B	0016787	molecular_function	hydrolase activity
B	0016813	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
B	0019547	biological_process	arginine catabolic process to ornithine
B	0033388	biological_process	putrescine biosynthetic process from arginine
B	0033389	biological_process	putrescine biosynthetic process from arginine, using agmatinase
B	0034214	biological_process	protein hexamerization
B	0046872	molecular_function	metal ion binding
C	0000050	biological_process	urea cycle
C	0004053	molecular_function	arginase activity
C	0005739	cellular_component	mitochondrion
C	0006525	biological_process	arginine metabolic process
C	0008783	molecular_function	agmatinase activity
C	0009446	biological_process	putrescine biosynthetic process
C	0016787	molecular_function	hydrolase activity
C	0016813	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
C	0019547	biological_process	arginine catabolic process to ornithine
C	0033388	biological_process	putrescine biosynthetic process from arginine
C	0033389	biological_process	putrescine biosynthetic process from arginine, using agmatinase
C	0034214	biological_process	protein hexamerization
C	0046872	molecular_function	metal ion binding
D	0000050	biological_process	urea cycle
D	0004053	molecular_function	arginase activity
D	0005739	cellular_component	mitochondrion
D	0006525	biological_process	arginine metabolic process
D	0008783	molecular_function	agmatinase activity
D	0009446	biological_process	putrescine biosynthetic process
D	0016787	molecular_function	hydrolase activity
D	0016813	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
D	0019547	biological_process	arginine catabolic process to ornithine
D	0033388	biological_process	putrescine biosynthetic process from arginine
D	0033389	biological_process	putrescine biosynthetic process from arginine, using agmatinase
D	0034214	biological_process	protein hexamerization
D	0046872	molecular_function	metal ion binding
E	0000050	biological_process	urea cycle
E	0004053	molecular_function	arginase activity
E	0005739	cellular_component	mitochondrion
E	0006525	biological_process	arginine metabolic process
E	0008783	molecular_function	agmatinase activity
E	0009446	biological_process	putrescine biosynthetic process
E	0016787	molecular_function	hydrolase activity
E	0016813	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
E	0019547	biological_process	arginine catabolic process to ornithine
E	0033388	biological_process	putrescine biosynthetic process from arginine
E	0033389	biological_process	putrescine biosynthetic process from arginine, using agmatinase
E	0034214	biological_process	protein hexamerization
E	0046872	molecular_function	metal ion binding
F	0000050	biological_process	urea cycle
F	0004053	molecular_function	arginase activity
F	0005739	cellular_component	mitochondrion
F	0006525	biological_process	arginine metabolic process
F	0008783	molecular_function	agmatinase activity
F	0009446	biological_process	putrescine biosynthetic process
F	0016787	molecular_function	hydrolase activity
F	0016813	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
F	0019547	biological_process	arginine catabolic process to ornithine
F	0033388	biological_process	putrescine biosynthetic process from arginine
F	0033389	biological_process	putrescine biosynthetic process from arginine, using agmatinase
F	0034214	biological_process	protein hexamerization
F	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue MN A 401

Chain	Residue
A	ASP181
A	HIS183
A	ASP266
A	ASP268
A	MN402
A	HOH512
A	HOH584

site_id	AC2
Number of Residues	7
Details	binding site for residue MN A 402

Chain	Residue
A	ASP185
A	ASP266
A	MN401
A	HOH512
A	HOH584
A	HIS157
A	ASP181

site_id	AC3
Number of Residues	7
Details	binding site for residue MN B 401

Chain	Residue
B	ASP181
B	HIS183
B	ASP266
B	ASP268
B	MN402
B	HOH534
B	HOH584

site_id	AC4
Number of Residues	7
Details	binding site for residue MN B 402

Chain	Residue
B	HIS157
B	ASP181
B	ASP185
B	ASP266
B	MN401
B	HOH534
B	HOH584

site_id	AC5
Number of Residues	7
Details	binding site for residue MN C 401

Chain	Residue
C	ASP181
C	HIS183
C	ASP266
C	ASP268
C	MN402
C	HOH512
C	HOH560

site_id	AC6
Number of Residues	6
Details	binding site for residue MN C 402

Chain	Residue
C	HIS157
C	ASP181
C	ASP185
C	ASP266
C	MN401
C	HOH512

site_id	AC7
Number of Residues	7
Details	binding site for residue MN D 401

Chain	Residue
D	ASP181
D	HIS183
D	ASP266
D	ASP268
D	MN402
D	HOH505
D	HOH569

site_id	AC8
Number of Residues	6
Details	binding site for residue MN D 402

Chain	Residue
D	HIS157
D	ASP181
D	ASP185
D	ASP266
D	MN401
D	HOH505

site_id	AC9
Number of Residues	7
Details	binding site for residue MN E 401

Chain	Residue
E	ASP181
E	HIS183
E	ASP266
E	ASP268
E	MN402
E	HOH510
E	HOH570

site_id	AD1
Number of Residues	7
Details	binding site for residue MN E 402

Chain	Residue
E	HIS157
E	ASP181
E	ASP185
E	ASP266
E	MN401
E	HOH510
E	HOH570

site_id	AD2
Number of Residues	7
Details	binding site for residue MN F 401

Chain	Residue
F	ASP181
F	HIS183
F	ASP266
F	ASP268
F	MN402
F	HOH547
F	HOH567

site_id	AD3
Number of Residues	6
Details	binding site for residue MN F 402

Chain	Residue
F	HIS157
F	ASP181
F	ASP185
F	ASP266
F	MN401
F	HOH547

Functional Information from PROSITE/UniProt

site_id	PS01053
Number of Residues	22
Details	ARGINASE_1 Arginase family signature. SIDVDsldPsiaPGvshhepgG

Chain	Residue	Details
A	SER264-GLY285

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	18
Details	BINDING: BINDING => ECO:0000269\|PubMed:32754173

Chain	Residue	Details
E	SER73
E	ASP92
E	SER220
F	SER73
F	ASP92
F	SER220
A	SER220
B	SER73
B	ASP92
B	SER220
C	SER73
C	ASP92
C	SER220
D	SER73
D	ASP92
D	SER220
A	SER73
A	ASP92

site_id	SWS_FT_FI2
Number of Residues	36
Details	BINDING: BINDING => ECO:0000255\|PROSITE-ProRule:PRU00742, ECO:0000269\|PubMed:32754173

Chain	Residue	Details
E	HIS157
E	ASP181
E	HIS183
E	ASP185
E	ASP266
E	ASP268
F	HIS157
F	ASP181
F	HIS183
F	ASP185
F	ASP266
F	ASP268
A	ASP266
A	ASP268
B	HIS157
B	ASP181
B	HIS183
B	ASP185
B	ASP266
B	ASP268
C	HIS157
C	ASP181
C	HIS183
C	ASP185
C	ASP266
C	ASP268
D	HIS157
D	ASP181
D	HIS183
D	ASP185
D	ASP266
D	ASP268
A	HIS157
A	ASP181
A	HIS183
A	ASP185

site_id	SWS_FT_FI3
Number of Residues	6
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:P53608

Chain	Residue	Details
C	GLU191
D	GLU191
E	GLU191
F	GLU191
A	GLU191
B	GLU191

site_id	SWS_FT_FI4
Number of Residues	6
Details	BINDING: BINDING => ECO:0000305\|PubMed:32754173

Chain	Residue	Details
B	GLU309
C	GLU309
D	GLU309
E	GLU309
F	GLU309
A	GLU309

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)