6VRL
Cryo-EM structure of the wild-type human serotonin transporter complexed with I-paroxetine and 8B6 Fab
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001666 | biological_process | response to hypoxia |
| A | 0005178 | molecular_function | integrin binding |
| A | 0005261 | molecular_function | monoatomic cation channel activity |
| A | 0005326 | molecular_function | neurotransmitter transmembrane transporter activity |
| A | 0005335 | molecular_function | serotonin:sodium:chloride symporter activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005768 | cellular_component | endosome |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0005925 | cellular_component | focal adhesion |
| A | 0006836 | biological_process | neurotransmitter transport |
| A | 0006837 | biological_process | serotonin transport |
| A | 0006865 | biological_process | amino acid transport |
| A | 0007584 | biological_process | response to nutrient |
| A | 0007613 | biological_process | memory |
| A | 0007623 | biological_process | circadian rhythm |
| A | 0008504 | molecular_function | monoamine transmembrane transporter activity |
| A | 0009410 | biological_process | response to xenobiotic stimulus |
| A | 0009636 | biological_process | response to toxic substance |
| A | 0010008 | cellular_component | endosome membrane |
| A | 0010033 | biological_process | obsolete response to organic substance |
| A | 0010628 | biological_process | positive regulation of gene expression |
| A | 0012505 | cellular_component | endomembrane system |
| A | 0014064 | biological_process | positive regulation of serotonin secretion |
| A | 0015297 | molecular_function | antiporter activity |
| A | 0015844 | biological_process | monoamine transport |
| A | 0016020 | cellular_component | membrane |
| A | 0017075 | molecular_function | syntaxin-1 binding |
| A | 0019811 | molecular_function | cocaine binding |
| A | 0021941 | biological_process | negative regulation of cerebellar granule cell precursor proliferation |
| A | 0031402 | molecular_function | sodium ion binding |
| A | 0032227 | biological_process | negative regulation of synaptic transmission, dopaminergic |
| A | 0032355 | biological_process | response to estradiol |
| A | 0035176 | biological_process | social behavior |
| A | 0035725 | biological_process | sodium ion transmembrane transport |
| A | 0042310 | biological_process | vasoconstriction |
| A | 0042713 | biological_process | sperm ejaculation |
| A | 0042734 | cellular_component | presynaptic membrane |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0042995 | cellular_component | cell projection |
| A | 0043005 | cellular_component | neuron projection |
| A | 0045121 | cellular_component | membrane raft |
| A | 0045202 | cellular_component | synapse |
| A | 0045211 | cellular_component | postsynaptic membrane |
| A | 0045665 | biological_process | negative regulation of neuron differentiation |
| A | 0045787 | biological_process | positive regulation of cell cycle |
| A | 0046621 | biological_process | negative regulation of organ growth |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0048148 | biological_process | behavioral response to cocaine |
| A | 0048484 | biological_process | enteric nervous system development |
| A | 0048854 | biological_process | brain morphogenesis |
| A | 0050998 | molecular_function | nitric-oxide synthase binding |
| A | 0051015 | molecular_function | actin filament binding |
| A | 0051378 | molecular_function | serotonin binding |
| A | 0051610 | biological_process | serotonin uptake |
| A | 0051899 | biological_process | membrane depolarization |
| A | 0070161 | cellular_component | anchoring junction |
| A | 0070527 | biological_process | platelet aggregation |
| A | 0071300 | biological_process | cellular response to retinoic acid |
| A | 0071310 | biological_process | obsolete cellular response to organic substance |
| A | 0071321 | biological_process | cellular response to cGMP |
| A | 0090067 | biological_process | regulation of thalamus size |
| A | 0098810 | biological_process | neurotransmitter reuptake |
| A | 0099154 | cellular_component | serotonergic synapse |
| A | 1990708 | biological_process | conditioned place preference |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH |
| Chain | Residue | Details |
| C | TYR212-HIS218 |
| site_id | PS00610 |
| Number of Residues | 15 |
| Details | NA_NEUROTRAN_SYMP_1 Sodium:neurotransmitter symporter family signature 1. WRFPYicyqNGGGaF |
| Chain | Residue | Details |
| A | TRP103-PHE117 |
| site_id | PS00754 |
| Number of Residues | 21 |
| Details | NA_NEUROTRAN_SYMP_2 Sodium:neurotransmitter symporter family signature 2. YLisSFTdqLPWtsCknswNT |
| Chain | Residue | Details |
| A | TYR186-THR206 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 201 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305 |
| Chain | Residue | Details |
| A | MET1-ASP87 | |
| A | GLU136-GLY160 | |
| A | LYS272-SER277 | |
| A | ALA348-ASP360 | |
| A | GLU444-GLU463 | |
| A | GLY517-ARG538 | |
| A | ARG596-VAL630 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:27049939 |
| Chain | Residue | Details |
| A | PHE88-ASN112 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 158 |
| Details | TOPO_DOM: Extracellular => ECO:0000305 |
| Chain | Residue | Details |
| A | GLY113-GLY115 | |
| A | LEU187-SER252 | |
| A | ARG298-GLY324 | |
| A | THR381-THR421 | |
| A | GLY484-GLU494 | |
| A | SER559-SER574 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:27049939 |
| Chain | Residue | Details |
| A | ALA116-MET135 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 25 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:27049939 |
| Chain | Residue | Details |
| A | ILE161-TYR186 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:27049939 |
| Chain | Residue | Details |
| A | TRP253-TRP271 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:27049939 |
| Chain | Residue | Details |
| A | GLY278-VAL297 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:27049939 |
| Chain | Residue | Details |
| A | VAL325-PHE347 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:27049939 |
| Chain | Residue | Details |
| A | ALA361-PHE380 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=8 => ECO:0000269|PubMed:27049939 |
| Chain | Residue | Details |
| A | PHE422-LEU443 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=9 => ECO:0000269|PubMed:27049939 |
| Chain | Residue | Details |
| A | ARG464-PHE483 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=10 => ECO:0000269|PubMed:27049939 |
| Chain | Residue | Details |
| A | TYR495-TYR516 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=11 => ECO:0000269|PubMed:27049939 |
| Chain | Residue | Details |
| A | ILE539-MET558 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=12 => ECO:0000269|PubMed:27049939 |
| Chain | Residue | Details |
| A | ILE575-TYR595 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q7K4Y6, ECO:0000269|PubMed:34851672, ECO:0000312|PDB:7LIA |
| Chain | Residue | Details |
| A | GLY94 | |
| A | VAL97 | |
| A | ASP437 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:34851672, ECO:0000305|PubMed:27049939, ECO:0000312|PDB:7LIA, ECO:0007744|PDB:5I6X |
| Chain | Residue | Details |
| A | ALA96 | |
| A | SER336 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:34851672, ECO:0000312|PDB:7MGW |
| Chain | Residue | Details |
| A | ASP98 | |
| A | GLU494 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:27049939, ECO:0007744|PDB:5I6X |
| Chain | Residue | Details |
| A | ASN101 | |
| A | ASN368 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q7K4Y6 |
| Chain | Residue | Details |
| A | LEU434 | |
| A | SER438 |
| site_id | SWS_FT_FI20 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:34851672, ECO:0000312|PDB:7LIA, ECO:0000312|PDB:7MGW |
| Chain | Residue | Details |
| A | THR439 | |
| A | PHE556 | |
| A | SER559 |
| site_id | SWS_FT_FI21 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:34851672, ECO:0000312|PDB:7LIA |
| Chain | Residue | Details |
| A | TYR495 |
| site_id | SWS_FT_FI22 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:21992875 |
| Chain | Residue | Details |
| A | TYR47 | |
| A | TYR142 |
| site_id | SWS_FT_FI23 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine; by PKG => ECO:0000269|PubMed:17913921 |
| Chain | Residue | Details |
| A | THR276 |
| site_id | SWS_FT_FI24 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0000269|PubMed:27049939 |
| Chain | Residue | Details |
| A | ASN208 | |
| A | ASN217 |
