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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6VR6

Structure of ALDH9A1 complexed with NAD+ in space group P1

Functional Information from GO Data
ChainGOidnamespacecontents
A0004029molecular_functionaldehyde dehydrogenase (NAD+) activity
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005829cellular_componentcytosol
A0006081biological_processaldehyde metabolic process
A0016491molecular_functionoxidoreductase activity
A0016620molecular_functionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
A0018467molecular_functionformaldehyde dehydrogenase (NAD+) activity
A0019145molecular_functionaminobutyraldehyde dehydrogenase (NAD+) activity
A0036094molecular_functionsmall molecule binding
A0042429biological_processserotonin catabolic process
A0045329biological_processcarnitine biosynthetic process
A0047105molecular_function4-trimethylammoniobutyraldehyde dehydrogenase activity
A0051289biological_processprotein homotetramerization
A0070062cellular_componentextracellular exosome
A0140087molecular_functionacetaldehyde dehydrogenase (NAD+) activity
B0004029molecular_functionaldehyde dehydrogenase (NAD+) activity
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005829cellular_componentcytosol
B0006081biological_processaldehyde metabolic process
B0016491molecular_functionoxidoreductase activity
B0016620molecular_functionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
B0018467molecular_functionformaldehyde dehydrogenase (NAD+) activity
B0019145molecular_functionaminobutyraldehyde dehydrogenase (NAD+) activity
B0036094molecular_functionsmall molecule binding
B0042429biological_processserotonin catabolic process
B0045329biological_processcarnitine biosynthetic process
B0047105molecular_function4-trimethylammoniobutyraldehyde dehydrogenase activity
B0051289biological_processprotein homotetramerization
B0070062cellular_componentextracellular exosome
B0140087molecular_functionacetaldehyde dehydrogenase (NAD+) activity
C0004029molecular_functionaldehyde dehydrogenase (NAD+) activity
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005829cellular_componentcytosol
C0006081biological_processaldehyde metabolic process
C0016491molecular_functionoxidoreductase activity
C0016620molecular_functionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
C0018467molecular_functionformaldehyde dehydrogenase (NAD+) activity
C0019145molecular_functionaminobutyraldehyde dehydrogenase (NAD+) activity
C0036094molecular_functionsmall molecule binding
C0042429biological_processserotonin catabolic process
C0045329biological_processcarnitine biosynthetic process
C0047105molecular_function4-trimethylammoniobutyraldehyde dehydrogenase activity
C0051289biological_processprotein homotetramerization
C0070062cellular_componentextracellular exosome
C0140087molecular_functionacetaldehyde dehydrogenase (NAD+) activity
D0004029molecular_functionaldehyde dehydrogenase (NAD+) activity
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005829cellular_componentcytosol
D0006081biological_processaldehyde metabolic process
D0016491molecular_functionoxidoreductase activity
D0016620molecular_functionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
D0018467molecular_functionformaldehyde dehydrogenase (NAD+) activity
D0019145molecular_functionaminobutyraldehyde dehydrogenase (NAD+) activity
D0036094molecular_functionsmall molecule binding
D0042429biological_processserotonin catabolic process
D0045329biological_processcarnitine biosynthetic process
D0047105molecular_function4-trimethylammoniobutyraldehyde dehydrogenase activity
D0051289biological_processprotein homotetramerization
D0070062cellular_componentextracellular exosome
D0140087molecular_functionacetaldehyde dehydrogenase (NAD+) activity
E0004029molecular_functionaldehyde dehydrogenase (NAD+) activity
E0005737cellular_componentcytoplasm
E0005739cellular_componentmitochondrion
E0005829cellular_componentcytosol
E0006081biological_processaldehyde metabolic process
E0016491molecular_functionoxidoreductase activity
E0016620molecular_functionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
E0018467molecular_functionformaldehyde dehydrogenase (NAD+) activity
E0019145molecular_functionaminobutyraldehyde dehydrogenase (NAD+) activity
E0036094molecular_functionsmall molecule binding
E0042429biological_processserotonin catabolic process
E0045329biological_processcarnitine biosynthetic process
E0047105molecular_function4-trimethylammoniobutyraldehyde dehydrogenase activity
E0051289biological_processprotein homotetramerization
E0070062cellular_componentextracellular exosome
E0140087molecular_functionacetaldehyde dehydrogenase (NAD+) activity
F0004029molecular_functionaldehyde dehydrogenase (NAD+) activity
F0005737cellular_componentcytoplasm
F0005739cellular_componentmitochondrion
F0005829cellular_componentcytosol
F0006081biological_processaldehyde metabolic process
F0016491molecular_functionoxidoreductase activity
F0016620molecular_functionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
F0018467molecular_functionformaldehyde dehydrogenase (NAD+) activity
F0019145molecular_functionaminobutyraldehyde dehydrogenase (NAD+) activity
F0036094molecular_functionsmall molecule binding
F0042429biological_processserotonin catabolic process
F0045329biological_processcarnitine biosynthetic process
F0047105molecular_function4-trimethylammoniobutyraldehyde dehydrogenase activity
F0051289biological_processprotein homotetramerization
F0070062cellular_componentextracellular exosome
F0140087molecular_functionacetaldehyde dehydrogenase (NAD+) activity
G0004029molecular_functionaldehyde dehydrogenase (NAD+) activity
G0005737cellular_componentcytoplasm
G0005739cellular_componentmitochondrion
G0005829cellular_componentcytosol
G0006081biological_processaldehyde metabolic process
G0016491molecular_functionoxidoreductase activity
G0016620molecular_functionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
G0018467molecular_functionformaldehyde dehydrogenase (NAD+) activity
G0019145molecular_functionaminobutyraldehyde dehydrogenase (NAD+) activity
G0036094molecular_functionsmall molecule binding
G0042429biological_processserotonin catabolic process
G0045329biological_processcarnitine biosynthetic process
G0047105molecular_function4-trimethylammoniobutyraldehyde dehydrogenase activity
G0051289biological_processprotein homotetramerization
G0070062cellular_componentextracellular exosome
G0140087molecular_functionacetaldehyde dehydrogenase (NAD+) activity
H0004029molecular_functionaldehyde dehydrogenase (NAD+) activity
H0005737cellular_componentcytoplasm
H0005739cellular_componentmitochondrion
H0005829cellular_componentcytosol
H0006081biological_processaldehyde metabolic process
H0016491molecular_functionoxidoreductase activity
H0016620molecular_functionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
H0018467molecular_functionformaldehyde dehydrogenase (NAD+) activity
H0019145molecular_functionaminobutyraldehyde dehydrogenase (NAD+) activity
H0036094molecular_functionsmall molecule binding
H0042429biological_processserotonin catabolic process
H0045329biological_processcarnitine biosynthetic process
H0047105molecular_function4-trimethylammoniobutyraldehyde dehydrogenase activity
H0051289biological_processprotein homotetramerization
H0070062cellular_componentextracellular exosome
H0140087molecular_functionacetaldehyde dehydrogenase (NAD+) activity
Functional Information from PDB Data
site_idAC1
Number of Residues23
Detailsbinding site for residue NAD A 501
ChainResidue
AILE153
AALA213
AGLY216
APHE230
ATHR231
AGLY232
ASER233
ATHR236
AILE240
AGLU254
ALEU255
AGLY154
AGLY256
ACYS288
AGLU391
APHE393
AALA155
ATRP156
AASN157
ALYS180
ASER182
APRO183
AGLY212
site_idAC2
Number of Residues14
Detailsbinding site for residue NAD B 501
ChainResidue
BILE153
BGLY154
BTRP156
BLYS180
BSER182
BPRO183
BALA213
BGLY216
BPHE230
BGLY232
BSER233
BTHR236
BLYS239
BILE240
site_idAC3
Number of Residues14
Detailsbinding site for residue NAD C 501
ChainResidue
CILE153
CGLY154
CTRP156
CLYS180
CSER182
CPRO183
CALA213
CGLY216
CGLN217
CPHE230
CGLY232
CSER233
CTHR236
CILE240
site_idAC4
Number of Residues14
Detailsbinding site for residue NAD D 501
ChainResidue
DILE153
DGLY154
DTRP156
DLYS180
DPRO183
DALA213
DGLY216
DGLN217
DPHE230
DGLY232
DSER233
DTHR236
DILE240
DMET243
site_idAC5
Number of Residues14
Detailsbinding site for residue NAD E 1001
ChainResidue
EILE153
EGLY154
ETRP156
ELYS180
ESER182
EPRO183
EALA213
EGLY216
EGLN217
EPHE230
ESER233
ETHR236
EILE240
EMET243
site_idAC6
Number of Residues13
Detailsbinding site for residue NAD F 501
ChainResidue
FILE153
FGLY154
FTRP156
FLYS180
FSER182
FPRO183
FALA213
FGLY216
FGLN217
FPHE230
FGLY232
FSER233
FTHR236
site_idAC7
Number of Residues16
Detailsbinding site for residue NAD G 501
ChainResidue
GGLY212
GALA213
GGLY216
GPHE230
GGLY232
GSER233
GTHR236
GILE240
GMET243
GILE153
GGLY154
GTRP156
GLYS180
GSER182
GPRO183
GGLY211
site_idAC8
Number of Residues14
Detailsbinding site for residue NAD H 501
ChainResidue
HILE153
HGLY154
HTRP156
HLYS180
HSER182
HPRO183
HGLY212
HALA213
HGLY216
HPHE230
HGLY232
HSER233
HTHR236
HILE240
Functional Information from PROSITE/UniProt
site_idPS00070
Number of Residues12
DetailsALDEHYDE_DEHYDR_CYS Aldehyde dehydrogenases cysteine active site. FlTQGQVCCNGT
ChainResidueDetails
APHE281-THR292
site_idPS00687
Number of Residues8
DetailsALDEHYDE_DEHYDR_GLU Aldehyde dehydrogenases glutamic acid active site. LELGGKSP
ChainResidueDetails
ALEU253-PRO260
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsActive site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU10007","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10008","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues8
DetailsActive site: {"description":"Nucleophile","evidences":[{"source":"PROSITE-ProRule","id":"PRU10007","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10008","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues48
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P56533","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues8
DetailsSite: {"description":"Transition state stabilizer","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues16
DetailsModified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q9JLJ2","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues8
DetailsModified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q9JLJ2","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues8
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues8
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9JLJ2","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues3
DetailsModified residue: {"description":"N-acetylserine; in 4-trimethylaminobutyraldehyde dehydrogenase, N-terminally processed","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAR-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Heiserich L.","Gottlieb E."]}},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

246031

PDB entries from 2025-12-10

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