6VQR
CryoEM Structure of the PfFNT-inhibitor complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005773 | cellular_component | vacuole |
| A | 0005774 | cellular_component | vacuolar membrane |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0015513 | molecular_function | high-affinity secondary active nitrite transmembrane transporter activity |
| A | 0015650 | molecular_function | lactate:proton symporter activity |
| A | 0015706 | biological_process | nitrate transmembrane transport |
| A | 0015707 | biological_process | nitrite transport |
| A | 0016020 | cellular_component | membrane |
| A | 0022857 | molecular_function | transmembrane transporter activity |
| A | 0035873 | biological_process | lactate transmembrane transport |
| A | 0055085 | biological_process | transmembrane transport |
| B | 0005773 | cellular_component | vacuole |
| B | 0005774 | cellular_component | vacuolar membrane |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0015513 | molecular_function | high-affinity secondary active nitrite transmembrane transporter activity |
| B | 0015650 | molecular_function | lactate:proton symporter activity |
| B | 0015706 | biological_process | nitrate transmembrane transport |
| B | 0015707 | biological_process | nitrite transport |
| B | 0016020 | cellular_component | membrane |
| B | 0022857 | molecular_function | transmembrane transporter activity |
| B | 0035873 | biological_process | lactate transmembrane transport |
| B | 0055085 | biological_process | transmembrane transport |
| C | 0005773 | cellular_component | vacuole |
| C | 0005774 | cellular_component | vacuolar membrane |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0015513 | molecular_function | high-affinity secondary active nitrite transmembrane transporter activity |
| C | 0015650 | molecular_function | lactate:proton symporter activity |
| C | 0015706 | biological_process | nitrate transmembrane transport |
| C | 0015707 | biological_process | nitrite transport |
| C | 0016020 | cellular_component | membrane |
| C | 0022857 | molecular_function | transmembrane transporter activity |
| C | 0035873 | biological_process | lactate transmembrane transport |
| C | 0055085 | biological_process | transmembrane transport |
| D | 0005773 | cellular_component | vacuole |
| D | 0005774 | cellular_component | vacuolar membrane |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0015513 | molecular_function | high-affinity secondary active nitrite transmembrane transporter activity |
| D | 0015650 | molecular_function | lactate:proton symporter activity |
| D | 0015706 | biological_process | nitrate transmembrane transport |
| D | 0015707 | biological_process | nitrite transport |
| D | 0016020 | cellular_component | membrane |
| D | 0022857 | molecular_function | transmembrane transporter activity |
| D | 0035873 | biological_process | lactate transmembrane transport |
| D | 0055085 | biological_process | transmembrane transport |
| E | 0005773 | cellular_component | vacuole |
| E | 0005774 | cellular_component | vacuolar membrane |
| E | 0005886 | cellular_component | plasma membrane |
| E | 0015513 | molecular_function | high-affinity secondary active nitrite transmembrane transporter activity |
| E | 0015650 | molecular_function | lactate:proton symporter activity |
| E | 0015706 | biological_process | nitrate transmembrane transport |
| E | 0015707 | biological_process | nitrite transport |
| E | 0016020 | cellular_component | membrane |
| E | 0022857 | molecular_function | transmembrane transporter activity |
| E | 0035873 | biological_process | lactate transmembrane transport |
| E | 0055085 | biological_process | transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | binding site for residue R7M A 401 |
| Chain | Residue |
| A | PHE90 |
| A | ALA93 |
| A | PHE94 |
| A | ILE97 |
| A | LEU104 |
| A | THR106 |
| A | GLY107 |
| A | VAL196 |
| A | HIS230 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | binding site for residue R7M B 401 |
| Chain | Residue |
| B | VAL54 |
| B | PHE90 |
| B | ALA93 |
| B | PHE94 |
| B | ILE97 |
| B | LEU104 |
| B | THR106 |
| B | GLY107 |
| B | VAL196 |
| B | HIS230 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue R7M C 401 |
| Chain | Residue |
| C | VAL54 |
| C | PHE94 |
| C | ILE97 |
| C | LEU104 |
| C | GLY107 |
| C | VAL196 |
| C | HIS230 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | binding site for residue R7M D 401 |
| Chain | Residue |
| D | PHE90 |
| D | ALA93 |
| D | PHE94 |
| D | ILE97 |
| D | LEU104 |
| D | THR106 |
| D | GLY107 |
| D | VAL196 |
| D | VAL200 |
| D | VAL220 |
| D | HIS230 |
| site_id | AC5 |
| Number of Residues | 11 |
| Details | binding site for residue R7M E 401 |
| Chain | Residue |
| E | PHE94 |
| E | ILE97 |
| E | ILE98 |
| E | SER102 |
| E | ASP103 |
| E | LEU104 |
| E | THR106 |
| E | GLY107 |
| E | VAL196 |
| E | VAL220 |
| E | HIS230 |
Functional Information from PROSITE/UniProt
| site_id | PS01006 |
| Number of Residues | 11 |
| Details | FORMATE_NITRITE_TP_2 Formate and nitrite transporters signature 2. AvgCNIFVCLA |
| Chain | Residue | Details |
| A | ALA189-ALA199 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 365 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305 |
| Chain | Residue | Details |
| A | MET1-CYS19 | |
| B | TYR281-ASN309 | |
| C | MET1-CYS19 | |
| C | ALA36-ASN40 | |
| C | GLY101-LYS122 | |
| C | LYS207-GLY209 | |
| C | TYR281-ASN309 | |
| D | MET1-CYS19 | |
| D | ALA36-ASN40 | |
| D | GLY101-LYS122 | |
| D | LYS207-GLY209 | |
| A | ALA36-ASN40 | |
| D | TYR281-ASN309 | |
| E | MET1-CYS19 | |
| E | ALA36-ASN40 | |
| E | GLY101-LYS122 | |
| E | LYS207-GLY209 | |
| E | TYR281-ASN309 | |
| A | GLY101-LYS122 | |
| A | LYS207-GLY209 | |
| A | TYR281-ASN309 | |
| B | MET1-CYS19 | |
| B | ALA36-ASN40 | |
| B | GLY101-LYS122 | |
| B | LYS207-GLY209 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 150 |
| Details | INTRAMEM: Helical => ECO:0000269|PubMed:33471955, ECO:0007744|PDB:6VQQ, ECO:0007744|PDB:6VQR, ECO:0007744|PDB:7MXY |
| Chain | Residue | Details |
| A | GLY20-LYS35 | |
| E | ASN164-HIS179 | |
| A | ASN164-HIS179 | |
| B | GLY20-LYS35 | |
| B | ASN164-HIS179 | |
| C | GLY20-LYS35 | |
| C | ASN164-HIS179 | |
| D | GLY20-LYS35 | |
| D | ASN164-HIS179 | |
| E | GLY20-LYS35 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 720 |
| Details | TRANSMEM: Helical => ECO:0000269|PubMed:33471955, ECO:0000269|PubMed:34499638, ECO:0007744|PDB:6VQQ, ECO:0007744|PDB:6VQR, ECO:0007744|PDB:7E26, ECO:0007744|PDB:7E27, ECO:0007744|PDB:7MXY |
| Chain | Residue | Details |
| A | LEU41-PHE68 | |
| B | PHE182-LEU206 | |
| B | ALA210-ALA226 | |
| B | VAL250-ILE280 | |
| C | LEU41-PHE68 | |
| C | SER80-THR100 | |
| C | LEU123-TYR150 | |
| C | PHE182-LEU206 | |
| C | ALA210-ALA226 | |
| C | VAL250-ILE280 | |
| D | LEU41-PHE68 | |
| A | SER80-THR100 | |
| D | SER80-THR100 | |
| D | LEU123-TYR150 | |
| D | PHE182-LEU206 | |
| D | ALA210-ALA226 | |
| D | VAL250-ILE280 | |
| E | LEU41-PHE68 | |
| E | SER80-THR100 | |
| E | LEU123-TYR150 | |
| E | PHE182-LEU206 | |
| E | ALA210-ALA226 | |
| A | LEU123-TYR150 | |
| E | VAL250-ILE280 | |
| A | PHE182-LEU206 | |
| A | ALA210-ALA226 | |
| A | VAL250-ILE280 | |
| B | LEU41-PHE68 | |
| B | SER80-THR100 | |
| B | LEU123-TYR150 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 225 |
| Details | TOPO_DOM: Extracellular => ECO:0000305 |
| Chain | Residue | Details |
| A | TYR69-ALA79 | |
| C | LEU151-LYS163 | |
| C | HIS180-THR181 | |
| C | GLY227-THR249 | |
| D | TYR69-ALA79 | |
| D | LEU151-LYS163 | |
| D | HIS180-THR181 | |
| D | GLY227-THR249 | |
| E | TYR69-ALA79 | |
| E | LEU151-LYS163 | |
| E | HIS180-THR181 | |
| A | LEU151-LYS163 | |
| E | GLY227-THR249 | |
| A | HIS180-THR181 | |
| A | GLY227-THR249 | |
| B | TYR69-ALA79 | |
| B | LEU151-LYS163 | |
| B | HIS180-THR181 | |
| B | GLY227-THR249 | |
| C | TYR69-ALA79 |
