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6VQK

Mammalian V-ATPase from rat brain collar and peripheral stalks rotational state 3 (from focused refinement)

Functional Information from GO Data
ChainGOidnamespacecontents
G0000221cellular_componentvacuolar proton-transporting V-type ATPase, V1 domain
G0005886cellular_componentplasma membrane
G0008150biological_processbiological_process
G0015078molecular_functionproton transmembrane transporter activity
G0016020cellular_componentmembrane
G0030665cellular_componentclathrin-coated vesicle membrane
G0030672cellular_componentsynaptic vesicle membrane
G0031410cellular_componentcytoplasmic vesicle
G0033176cellular_componentproton-transporting V-type ATPase complex
G0033180cellular_componentproton-transporting V-type ATPase, V1 domain
G0045177cellular_componentapical part of cell
G0045202cellular_componentsynapse
G0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
G0097401biological_processsynaptic vesicle lumen acidification
G0098850cellular_componentextrinsic component of synaptic vesicle membrane
G1902600biological_processproton transmembrane transport
G1904949cellular_componentATPase complex
I0000221cellular_componentvacuolar proton-transporting V-type ATPase, V1 domain
I0005737cellular_componentcytoplasm
I0005768cellular_componentendosome
I0005829cellular_componentcytosol
I0005886cellular_componentplasma membrane
I0005902cellular_componentmicrovillus
I0016324cellular_componentapical plasma membrane
I0030665cellular_componentclathrin-coated vesicle membrane
I0030672cellular_componentsynaptic vesicle membrane
I0031410cellular_componentcytoplasmic vesicle
I0033178cellular_componentproton-transporting two-sector ATPase complex, catalytic domain
I0045202cellular_componentsynapse
I0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
I0051117molecular_functionATPase binding
I0097401biological_processsynaptic vesicle lumen acidification
I0098850cellular_componentextrinsic component of synaptic vesicle membrane
I1902600biological_processproton transmembrane transport
J0000221cellular_componentvacuolar proton-transporting V-type ATPase, V1 domain
J0005737cellular_componentcytoplasm
J0005768cellular_componentendosome
J0005829cellular_componentcytosol
J0005886cellular_componentplasma membrane
J0005902cellular_componentmicrovillus
J0016324cellular_componentapical plasma membrane
J0030665cellular_componentclathrin-coated vesicle membrane
J0030672cellular_componentsynaptic vesicle membrane
J0031410cellular_componentcytoplasmic vesicle
J0033178cellular_componentproton-transporting two-sector ATPase complex, catalytic domain
J0045202cellular_componentsynapse
J0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
J0051117molecular_functionATPase binding
J0097401biological_processsynaptic vesicle lumen acidification
J0098850cellular_componentextrinsic component of synaptic vesicle membrane
J1902600biological_processproton transmembrane transport
K0000221cellular_componentvacuolar proton-transporting V-type ATPase, V1 domain
K0005737cellular_componentcytoplasm
K0005768cellular_componentendosome
K0005829cellular_componentcytosol
K0005886cellular_componentplasma membrane
K0005902cellular_componentmicrovillus
K0016324cellular_componentapical plasma membrane
K0030665cellular_componentclathrin-coated vesicle membrane
K0030672cellular_componentsynaptic vesicle membrane
K0031410cellular_componentcytoplasmic vesicle
K0033178cellular_componentproton-transporting two-sector ATPase complex, catalytic domain
K0045202cellular_componentsynapse
K0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
K0051117molecular_functionATPase binding
K0097401biological_processsynaptic vesicle lumen acidification
K0098850cellular_componentextrinsic component of synaptic vesicle membrane
K1902600biological_processproton transmembrane transport
M0000221cellular_componentvacuolar proton-transporting V-type ATPase, V1 domain
M0008553molecular_functionP-type proton-exporting transporter activity
M0012505cellular_componentendomembrane system
M0016471cellular_componentvacuolar proton-transporting V-type ATPase complex
M0016887molecular_functionATP hydrolysis activity
M0030672cellular_componentsynaptic vesicle membrane
M0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
M0097401biological_processsynaptic vesicle lumen acidification
M0098850cellular_componentextrinsic component of synaptic vesicle membrane
M1902600biological_processproton transmembrane transport
N0000221cellular_componentvacuolar proton-transporting V-type ATPase, V1 domain
N0008553molecular_functionP-type proton-exporting transporter activity
N0012505cellular_componentendomembrane system
N0016471cellular_componentvacuolar proton-transporting V-type ATPase complex
N0016887molecular_functionATP hydrolysis activity
N0030672cellular_componentsynaptic vesicle membrane
N0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
N0097401biological_processsynaptic vesicle lumen acidification
N0098850cellular_componentextrinsic component of synaptic vesicle membrane
N1902600biological_processproton transmembrane transport
O0000221cellular_componentvacuolar proton-transporting V-type ATPase, V1 domain
O0008553molecular_functionP-type proton-exporting transporter activity
O0012505cellular_componentendomembrane system
O0016471cellular_componentvacuolar proton-transporting V-type ATPase complex
O0016887molecular_functionATP hydrolysis activity
O0030672cellular_componentsynaptic vesicle membrane
O0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
O0097401biological_processsynaptic vesicle lumen acidification
O0098850cellular_componentextrinsic component of synaptic vesicle membrane
O1902600biological_processproton transmembrane transport
a0000220cellular_componentvacuolar proton-transporting V-type ATPase, V0 domain
a0005737cellular_componentcytoplasm
a0005886cellular_componentplasma membrane
a0007035biological_processvacuolar acidification
a0008150biological_processbiological_process
a0016020cellular_componentmembrane
a0016241biological_processregulation of macroautophagy
a0016471cellular_componentvacuolar proton-transporting V-type ATPase complex
a0030665cellular_componentclathrin-coated vesicle membrane
a0030672cellular_componentsynaptic vesicle membrane
a0031410cellular_componentcytoplasmic vesicle
a0033179cellular_componentproton-transporting V-type ATPase, V0 domain
a0042470cellular_componentmelanosome
a0043195cellular_componentterminal bouton
a0045202cellular_componentsynapse
a0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
a0048471cellular_componentperinuclear region of cytoplasm
a0051117molecular_functionATPase binding
a0097401biological_processsynaptic vesicle lumen acidification
a1902600biological_processproton transmembrane transport
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues510
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
aMET1-GLU388
aGLU427-SER441
aSER556-PHE573
aARG660-THR725
aPHE811-GLU838

site_idSWS_FT_FI2
Number of Residues183
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
aILE389-PHE407
aPHE410-ARG426
aMET442-SER471
aPHE536-LEU555
aILE574-LYS594
aLEU640-LEU659
aILE726-ALA750
aGLY772-GLU810

site_idSWS_FT_FI3
Number of Residues128
DetailsTOPO_DOM: Vacuolar => ECO:0000255
ChainResidueDetails
aGLY408-ASP409
aLEU472-SER535
aTRP595-PHE639
aGLN751-ALA771

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q9Z1G4
ChainResidueDetails
aTHR250

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q93050
ChainResidueDetails
aTHR360

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q9Z1G4
ChainResidueDetails
aTYR364

227344

PDB entries from 2024-11-13

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