6VQH

Mammalian V-ATPase from rat brain membrane-embedded Vo region rotational state 3 (from focused refinement)

Functional Information from GO Data

Chain	GOid	namespace	contents
H	0005813	cellular_component	centrosome
H	0005929	cellular_component	cilium
H	0006811	biological_process	monoatomic ion transport
H	0016020	cellular_component	membrane
H	0030030	biological_process	cell projection organization
H	0030665	cellular_component	clathrin-coated vesicle membrane
H	0033176	cellular_component	proton-transporting V-type ATPase complex
H	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
H	0060271	biological_process	cilium assembly
H	0061512	biological_process	protein localization to cilium
H	0097401	biological_process	synaptic vesicle lumen acidification
H	0098850	cellular_component	extrinsic component of synaptic vesicle membrane
H	1902600	biological_process	proton transmembrane transport
L	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
L	0006811	biological_process	monoatomic ion transport
L	0016020	cellular_component	membrane
L	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
L	0030665	cellular_component	clathrin-coated vesicle membrane
L	0030672	cellular_component	synaptic vesicle membrane
L	0031410	cellular_component	cytoplasmic vesicle
L	0033176	cellular_component	proton-transporting V-type ATPase complex
L	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
L	0034220	biological_process	monoatomic ion transmembrane transport
L	0045202	cellular_component	synapse
L	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
L	0097401	biological_process	synaptic vesicle lumen acidification
L	0098850	cellular_component	extrinsic component of synaptic vesicle membrane
L	1902600	biological_process	proton transmembrane transport
a	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
a	0005737	cellular_component	cytoplasm
a	0005886	cellular_component	plasma membrane
a	0006811	biological_process	monoatomic ion transport
a	0007035	biological_process	vacuolar acidification
a	0008150	biological_process	biological_process
a	0016020	cellular_component	membrane
a	0016241	biological_process	regulation of macroautophagy
a	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
a	0030665	cellular_component	clathrin-coated vesicle membrane
a	0030672	cellular_component	synaptic vesicle membrane
a	0031410	cellular_component	cytoplasmic vesicle
a	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
a	0042470	cellular_component	melanosome
a	0043195	cellular_component	terminal bouton
a	0045202	cellular_component	synapse
a	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
a	0048471	cellular_component	perinuclear region of cytoplasm
a	0051117	molecular_function	ATPase binding
a	0097401	biological_process	synaptic vesicle lumen acidification
a	1902600	biological_process	proton transmembrane transport
b	0005768	cellular_component	endosome
b	0006811	biological_process	monoatomic ion transport
b	0015078	molecular_function	proton transmembrane transporter activity
b	0016020	cellular_component	membrane
b	0030665	cellular_component	clathrin-coated vesicle membrane
b	0033176	cellular_component	proton-transporting V-type ATPase complex
b	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
b	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
b	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
b	1902600	biological_process	proton transmembrane transport
d	0005765	cellular_component	lysosomal membrane
d	0005769	cellular_component	early endosome
d	0005813	cellular_component	centrosome
d	0006811	biological_process	monoatomic ion transport
d	0006879	biological_process	intracellular iron ion homeostasis
d	0008021	cellular_component	synaptic vesicle
d	0016020	cellular_component	membrane
d	0016324	cellular_component	apical plasma membrane
d	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
d	0030665	cellular_component	clathrin-coated vesicle membrane
d	0030672	cellular_component	synaptic vesicle membrane
d	0032991	cellular_component	protein-containing complex
d	0033176	cellular_component	proton-transporting V-type ATPase complex
d	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
d	0036295	biological_process	cellular response to increased oxygen levels
d	0042592	biological_process	homeostatic process
d	0043679	cellular_component	axon terminus
d	0044877	molecular_function	protein-containing complex binding
d	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
d	0097401	biological_process	synaptic vesicle lumen acidification
d	1902600	biological_process	proton transmembrane transport
e	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
e	0006811	biological_process	monoatomic ion transport
e	0016020	cellular_component	membrane
e	0030665	cellular_component	clathrin-coated vesicle membrane
e	0030672	cellular_component	synaptic vesicle membrane
e	0031410	cellular_component	cytoplasmic vesicle
e	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
e	0045202	cellular_component	synapse
e	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
e	0055085	biological_process	transmembrane transport
e	0097401	biological_process	synaptic vesicle lumen acidification
e	1902600	biological_process	proton transmembrane transport
f	0004521	molecular_function	RNA endonuclease activity
f	0006898	biological_process	receptor-mediated endocytosis
f	0016020	cellular_component	membrane
f	0016589	cellular_component	NURF complex
f	0019065	biological_process	receptor-mediated endocytosis of virus by host cell
f	0042802	molecular_function	identical protein binding
f	0048388	biological_process	endosomal lumen acidification
f	0071339	cellular_component	MLL1 complex
f	0090304	biological_process	nucleic acid metabolic process
f	1902600	biological_process	proton transmembrane transport
g	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
g	0006811	biological_process	monoatomic ion transport
g	0008021	cellular_component	synaptic vesicle
g	0015078	molecular_function	proton transmembrane transporter activity
g	0016020	cellular_component	membrane
g	0030177	biological_process	positive regulation of Wnt signaling pathway
g	0030665	cellular_component	clathrin-coated vesicle membrane
g	0030672	cellular_component	synaptic vesicle membrane
g	0031410	cellular_component	cytoplasmic vesicle
g	0031625	molecular_function	ubiquitin protein ligase binding
g	0033176	cellular_component	proton-transporting V-type ATPase complex
g	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
g	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
g	0045202	cellular_component	synapse
g	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
g	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
g	0097401	biological_process	synaptic vesicle lumen acidification
g	0098588	cellular_component	bounding membrane of organelle
g	1902600	biological_process	proton transmembrane transport
g	1904093	biological_process	negative regulation of autophagic cell death
h	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
h	0006811	biological_process	monoatomic ion transport
h	0008021	cellular_component	synaptic vesicle
h	0015078	molecular_function	proton transmembrane transporter activity
h	0016020	cellular_component	membrane
h	0030177	biological_process	positive regulation of Wnt signaling pathway
h	0030665	cellular_component	clathrin-coated vesicle membrane
h	0030672	cellular_component	synaptic vesicle membrane
h	0031410	cellular_component	cytoplasmic vesicle
h	0031625	molecular_function	ubiquitin protein ligase binding
h	0033176	cellular_component	proton-transporting V-type ATPase complex
h	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
h	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
h	0045202	cellular_component	synapse
h	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
h	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
h	0097401	biological_process	synaptic vesicle lumen acidification
h	0098588	cellular_component	bounding membrane of organelle
h	1902600	biological_process	proton transmembrane transport
h	1904093	biological_process	negative regulation of autophagic cell death
i	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
i	0006811	biological_process	monoatomic ion transport
i	0008021	cellular_component	synaptic vesicle
i	0015078	molecular_function	proton transmembrane transporter activity
i	0016020	cellular_component	membrane
i	0030177	biological_process	positive regulation of Wnt signaling pathway
i	0030665	cellular_component	clathrin-coated vesicle membrane
i	0030672	cellular_component	synaptic vesicle membrane
i	0031410	cellular_component	cytoplasmic vesicle
i	0031625	molecular_function	ubiquitin protein ligase binding
i	0033176	cellular_component	proton-transporting V-type ATPase complex
i	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
i	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
i	0045202	cellular_component	synapse
i	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
i	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
i	0097401	biological_process	synaptic vesicle lumen acidification
i	0098588	cellular_component	bounding membrane of organelle
i	1902600	biological_process	proton transmembrane transport
i	1904093	biological_process	negative regulation of autophagic cell death
j	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
j	0006811	biological_process	monoatomic ion transport
j	0008021	cellular_component	synaptic vesicle
j	0015078	molecular_function	proton transmembrane transporter activity
j	0016020	cellular_component	membrane
j	0030177	biological_process	positive regulation of Wnt signaling pathway
j	0030665	cellular_component	clathrin-coated vesicle membrane
j	0030672	cellular_component	synaptic vesicle membrane
j	0031410	cellular_component	cytoplasmic vesicle
j	0031625	molecular_function	ubiquitin protein ligase binding
j	0033176	cellular_component	proton-transporting V-type ATPase complex
j	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
j	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
j	0045202	cellular_component	synapse
j	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
j	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
j	0097401	biological_process	synaptic vesicle lumen acidification
j	0098588	cellular_component	bounding membrane of organelle
j	1902600	biological_process	proton transmembrane transport
j	1904093	biological_process	negative regulation of autophagic cell death
k	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
k	0006811	biological_process	monoatomic ion transport
k	0008021	cellular_component	synaptic vesicle
k	0015078	molecular_function	proton transmembrane transporter activity
k	0016020	cellular_component	membrane
k	0030177	biological_process	positive regulation of Wnt signaling pathway
k	0030665	cellular_component	clathrin-coated vesicle membrane
k	0030672	cellular_component	synaptic vesicle membrane
k	0031410	cellular_component	cytoplasmic vesicle
k	0031625	molecular_function	ubiquitin protein ligase binding
k	0033176	cellular_component	proton-transporting V-type ATPase complex
k	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
k	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
k	0045202	cellular_component	synapse
k	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
k	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
k	0097401	biological_process	synaptic vesicle lumen acidification
k	0098588	cellular_component	bounding membrane of organelle
k	1902600	biological_process	proton transmembrane transport
k	1904093	biological_process	negative regulation of autophagic cell death
l	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
l	0006811	biological_process	monoatomic ion transport
l	0008021	cellular_component	synaptic vesicle
l	0015078	molecular_function	proton transmembrane transporter activity
l	0016020	cellular_component	membrane
l	0030177	biological_process	positive regulation of Wnt signaling pathway
l	0030665	cellular_component	clathrin-coated vesicle membrane
l	0030672	cellular_component	synaptic vesicle membrane
l	0031410	cellular_component	cytoplasmic vesicle
l	0031625	molecular_function	ubiquitin protein ligase binding
l	0033176	cellular_component	proton-transporting V-type ATPase complex
l	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
l	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
l	0045202	cellular_component	synapse
l	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
l	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
l	0097401	biological_process	synaptic vesicle lumen acidification
l	0098588	cellular_component	bounding membrane of organelle
l	1902600	biological_process	proton transmembrane transport
l	1904093	biological_process	negative regulation of autophagic cell death
m	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
m	0006811	biological_process	monoatomic ion transport
m	0008021	cellular_component	synaptic vesicle
m	0015078	molecular_function	proton transmembrane transporter activity
m	0016020	cellular_component	membrane
m	0030177	biological_process	positive regulation of Wnt signaling pathway
m	0030665	cellular_component	clathrin-coated vesicle membrane
m	0030672	cellular_component	synaptic vesicle membrane
m	0031410	cellular_component	cytoplasmic vesicle
m	0031625	molecular_function	ubiquitin protein ligase binding
m	0033176	cellular_component	proton-transporting V-type ATPase complex
m	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
m	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
m	0045202	cellular_component	synapse
m	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
m	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
m	0097401	biological_process	synaptic vesicle lumen acidification
m	0098588	cellular_component	bounding membrane of organelle
m	1902600	biological_process	proton transmembrane transport
m	1904093	biological_process	negative regulation of autophagic cell death
n	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
n	0006811	biological_process	monoatomic ion transport
n	0008021	cellular_component	synaptic vesicle
n	0015078	molecular_function	proton transmembrane transporter activity
n	0016020	cellular_component	membrane
n	0030177	biological_process	positive regulation of Wnt signaling pathway
n	0030665	cellular_component	clathrin-coated vesicle membrane
n	0030672	cellular_component	synaptic vesicle membrane
n	0031410	cellular_component	cytoplasmic vesicle
n	0031625	molecular_function	ubiquitin protein ligase binding
n	0033176	cellular_component	proton-transporting V-type ATPase complex
n	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
n	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
n	0045202	cellular_component	synapse
n	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
n	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
n	0097401	biological_process	synaptic vesicle lumen acidification
n	0098588	cellular_component	bounding membrane of organelle
n	1902600	biological_process	proton transmembrane transport
n	1904093	biological_process	negative regulation of autophagic cell death
o	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
o	0006811	biological_process	monoatomic ion transport
o	0008021	cellular_component	synaptic vesicle
o	0015078	molecular_function	proton transmembrane transporter activity
o	0016020	cellular_component	membrane
o	0030177	biological_process	positive regulation of Wnt signaling pathway
o	0030665	cellular_component	clathrin-coated vesicle membrane
o	0030672	cellular_component	synaptic vesicle membrane
o	0031410	cellular_component	cytoplasmic vesicle
o	0031625	molecular_function	ubiquitin protein ligase binding
o	0033176	cellular_component	proton-transporting V-type ATPase complex
o	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
o	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
o	0045202	cellular_component	synapse
o	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
o	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
o	0097401	biological_process	synaptic vesicle lumen acidification
o	0098588	cellular_component	bounding membrane of organelle
o	1902600	biological_process	proton transmembrane transport
o	1904093	biological_process	negative regulation of autophagic cell death
p	0016020	cellular_component	membrane
p	0038023	molecular_function	signaling receptor activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1010
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	128
Details	Topological domain: {"description":"Vacuolar","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	364
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q93050","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q9Z1G4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	6
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"24090084","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	153
Details	Topological domain: {"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	9
Details	Site: {"description":"Essential for proton translocation","evidences":[{"source":"PubMed","id":"32165585","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---