6VQB

Mammalian V-ATPase from rat brain soluble V1 region rotational state 2 with SidK and ADP (from focused refinement)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0006811	biological_process	monoatomic ion transport
A	0016887	molecular_function	ATP hydrolysis activity
A	0030665	cellular_component	clathrin-coated vesicle membrane
A	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
A	0042592	biological_process	homeostatic process
A	0046034	biological_process	ATP metabolic process
A	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
A	1902600	biological_process	proton transmembrane transport
B	0000166	molecular_function	nucleotide binding
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0006811	biological_process	monoatomic ion transport
B	0016887	molecular_function	ATP hydrolysis activity
B	0030665	cellular_component	clathrin-coated vesicle membrane
B	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
B	0042592	biological_process	homeostatic process
B	0046034	biological_process	ATP metabolic process
B	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
B	1902600	biological_process	proton transmembrane transport
C	0000166	molecular_function	nucleotide binding
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0006811	biological_process	monoatomic ion transport
C	0016887	molecular_function	ATP hydrolysis activity
C	0030665	cellular_component	clathrin-coated vesicle membrane
C	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
C	0042592	biological_process	homeostatic process
C	0046034	biological_process	ATP metabolic process
C	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
C	1902600	biological_process	proton transmembrane transport
D	0000166	molecular_function	nucleotide binding
D	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
D	0001726	cellular_component	ruffle
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0005902	cellular_component	microvillus
D	0006811	biological_process	monoatomic ion transport
D	0007035	biological_process	vacuolar acidification
D	0016324	cellular_component	apical plasma membrane
D	0019725	biological_process	cellular homeostasis
D	0030641	biological_process	regulation of cellular pH
D	0030665	cellular_component	clathrin-coated vesicle membrane
D	0030672	cellular_component	synaptic vesicle membrane
D	0031410	cellular_component	cytoplasmic vesicle
D	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
D	0042470	cellular_component	melanosome
D	0046034	biological_process	ATP metabolic process
D	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
D	0097401	biological_process	synaptic vesicle lumen acidification
D	0098850	cellular_component	extrinsic component of synaptic vesicle membrane
D	1902600	biological_process	proton transmembrane transport
E	0000166	molecular_function	nucleotide binding
E	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
E	0001726	cellular_component	ruffle
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005886	cellular_component	plasma membrane
E	0005902	cellular_component	microvillus
E	0006811	biological_process	monoatomic ion transport
E	0007035	biological_process	vacuolar acidification
E	0016324	cellular_component	apical plasma membrane
E	0019725	biological_process	cellular homeostasis
E	0030641	biological_process	regulation of cellular pH
E	0030665	cellular_component	clathrin-coated vesicle membrane
E	0030672	cellular_component	synaptic vesicle membrane
E	0031410	cellular_component	cytoplasmic vesicle
E	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
E	0042470	cellular_component	melanosome
E	0046034	biological_process	ATP metabolic process
E	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
E	0097401	biological_process	synaptic vesicle lumen acidification
E	0098850	cellular_component	extrinsic component of synaptic vesicle membrane
E	1902600	biological_process	proton transmembrane transport
F	0000166	molecular_function	nucleotide binding
F	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
F	0001726	cellular_component	ruffle
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005886	cellular_component	plasma membrane
F	0005902	cellular_component	microvillus
F	0006811	biological_process	monoatomic ion transport
F	0007035	biological_process	vacuolar acidification
F	0016324	cellular_component	apical plasma membrane
F	0019725	biological_process	cellular homeostasis
F	0030641	biological_process	regulation of cellular pH
F	0030665	cellular_component	clathrin-coated vesicle membrane
F	0030672	cellular_component	synaptic vesicle membrane
F	0031410	cellular_component	cytoplasmic vesicle
F	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
F	0042470	cellular_component	melanosome
F	0046034	biological_process	ATP metabolic process
F	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
F	0097401	biological_process	synaptic vesicle lumen acidification
F	0098850	cellular_component	extrinsic component of synaptic vesicle membrane
F	1902600	biological_process	proton transmembrane transport
H	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
I	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
I	0005737	cellular_component	cytoplasm
I	0005768	cellular_component	endosome
I	0005829	cellular_component	cytosol
I	0005902	cellular_component	microvillus
I	0006811	biological_process	monoatomic ion transport
I	0016324	cellular_component	apical plasma membrane
I	0030665	cellular_component	clathrin-coated vesicle membrane
I	0030672	cellular_component	synaptic vesicle membrane
I	0031410	cellular_component	cytoplasmic vesicle
I	0033178	cellular_component	proton-transporting two-sector ATPase complex, catalytic domain
I	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
I	0051117	molecular_function	ATPase binding
I	0097401	biological_process	synaptic vesicle lumen acidification
I	0098850	cellular_component	extrinsic component of synaptic vesicle membrane
I	1902600	biological_process	proton transmembrane transport
J	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
J	0005737	cellular_component	cytoplasm
J	0005768	cellular_component	endosome
J	0005829	cellular_component	cytosol
J	0005902	cellular_component	microvillus
J	0006811	biological_process	monoatomic ion transport
J	0016324	cellular_component	apical plasma membrane
J	0030665	cellular_component	clathrin-coated vesicle membrane
J	0030672	cellular_component	synaptic vesicle membrane
J	0031410	cellular_component	cytoplasmic vesicle
J	0033178	cellular_component	proton-transporting two-sector ATPase complex, catalytic domain
J	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
J	0051117	molecular_function	ATPase binding
J	0097401	biological_process	synaptic vesicle lumen acidification
J	0098850	cellular_component	extrinsic component of synaptic vesicle membrane
J	1902600	biological_process	proton transmembrane transport
K	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
K	0005737	cellular_component	cytoplasm
K	0005768	cellular_component	endosome
K	0005829	cellular_component	cytosol
K	0005902	cellular_component	microvillus
K	0006811	biological_process	monoatomic ion transport
K	0016324	cellular_component	apical plasma membrane
K	0030665	cellular_component	clathrin-coated vesicle membrane
K	0030672	cellular_component	synaptic vesicle membrane
K	0031410	cellular_component	cytoplasmic vesicle
K	0033178	cellular_component	proton-transporting two-sector ATPase complex, catalytic domain
K	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
K	0051117	molecular_function	ATPase binding
K	0097401	biological_process	synaptic vesicle lumen acidification
K	0098850	cellular_component	extrinsic component of synaptic vesicle membrane
K	1902600	biological_process	proton transmembrane transport
M	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
M	0006811	biological_process	monoatomic ion transport
M	0008553	molecular_function	P-type proton-exporting transporter activity
M	0012505	cellular_component	endomembrane system
M	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
M	0016887	molecular_function	ATP hydrolysis activity
M	0030672	cellular_component	synaptic vesicle membrane
M	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
M	0097401	biological_process	synaptic vesicle lumen acidification
M	0098850	cellular_component	extrinsic component of synaptic vesicle membrane
M	1902600	biological_process	proton transmembrane transport
N	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
N	0006811	biological_process	monoatomic ion transport
N	0008553	molecular_function	P-type proton-exporting transporter activity
N	0012505	cellular_component	endomembrane system
N	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
N	0016887	molecular_function	ATP hydrolysis activity
N	0030672	cellular_component	synaptic vesicle membrane
N	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
N	0097401	biological_process	synaptic vesicle lumen acidification
N	0098850	cellular_component	extrinsic component of synaptic vesicle membrane
N	1902600	biological_process	proton transmembrane transport
O	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
O	0006811	biological_process	monoatomic ion transport
O	0008553	molecular_function	P-type proton-exporting transporter activity
O	0012505	cellular_component	endomembrane system
O	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
O	0016887	molecular_function	ATP hydrolysis activity
O	0030672	cellular_component	synaptic vesicle membrane
O	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
O	0097401	biological_process	synaptic vesicle lumen acidification
O	0098850	cellular_component	extrinsic component of synaptic vesicle membrane
O	1902600	biological_process	proton transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue ADP A 701

Chain	Residue
A	ALA251
A	GLN522
A	GLY524
A	TYR525
D	ARG400
D	LYS403
A	PHE252
A	GLY253
A	CYS254
A	GLY255
A	LYS256
A	THR257
A	VAL258
A	PHE445

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Functional Information from PROSITE/UniProt

site_id	PS00152
Number of Residues	10
Details	ATPASE_ALPHA_BETA ATP synthase alpha and beta subunits signature. PPINVLPSLS

Chain	Residue	Details
D	PRO390-SER399
A	PRO446-SER455

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI5
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32165585","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6VQ6","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"6VQ9","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"6VQ7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VQ8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VQA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VQB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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