6VPU

1.90 Angstrom Resolution Crystal Structure Phosphoadenosine Phosphosulfate Reductase (CysH) from Vibrio vulnificus

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004604	molecular_function	phosphoadenylyl-sulfate reductase (thioredoxin) activity
A	0005737	cellular_component	cytoplasm
A	0016491	molecular_function	oxidoreductase activity
A	0019379	biological_process	sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)
A	0070814	biological_process	hydrogen sulfide biosynthetic process
B	0003824	molecular_function	catalytic activity
B	0004604	molecular_function	phosphoadenylyl-sulfate reductase (thioredoxin) activity
B	0005737	cellular_component	cytoplasm
B	0016491	molecular_function	oxidoreductase activity
B	0019379	biological_process	sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)
B	0070814	biological_process	hydrogen sulfide biosynthetic process
C	0003824	molecular_function	catalytic activity
C	0004604	molecular_function	phosphoadenylyl-sulfate reductase (thioredoxin) activity
C	0005737	cellular_component	cytoplasm
C	0016491	molecular_function	oxidoreductase activity
C	0019379	biological_process	sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)
C	0070814	biological_process	hydrogen sulfide biosynthetic process
D	0003824	molecular_function	catalytic activity
D	0004604	molecular_function	phosphoadenylyl-sulfate reductase (thioredoxin) activity
D	0005737	cellular_component	cytoplasm
D	0016491	molecular_function	oxidoreductase activity
D	0019379	biological_process	sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)
D	0070814	biological_process	hydrogen sulfide biosynthetic process
E	0003824	molecular_function	catalytic activity
E	0004604	molecular_function	phosphoadenylyl-sulfate reductase (thioredoxin) activity
E	0005737	cellular_component	cytoplasm
E	0016491	molecular_function	oxidoreductase activity
E	0019379	biological_process	sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)
E	0070814	biological_process	hydrogen sulfide biosynthetic process
F	0003824	molecular_function	catalytic activity
F	0004604	molecular_function	phosphoadenylyl-sulfate reductase (thioredoxin) activity
F	0005737	cellular_component	cytoplasm
F	0016491	molecular_function	oxidoreductase activity
F	0019379	biological_process	sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)
F	0070814	biological_process	hydrogen sulfide biosynthetic process
G	0003824	molecular_function	catalytic activity
G	0004604	molecular_function	phosphoadenylyl-sulfate reductase (thioredoxin) activity
G	0005737	cellular_component	cytoplasm
G	0016491	molecular_function	oxidoreductase activity
G	0019379	biological_process	sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)
G	0070814	biological_process	hydrogen sulfide biosynthetic process
H	0003824	molecular_function	catalytic activity
H	0004604	molecular_function	phosphoadenylyl-sulfate reductase (thioredoxin) activity
H	0005737	cellular_component	cytoplasm
H	0016491	molecular_function	oxidoreductase activity
H	0019379	biological_process	sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)
H	0070814	biological_process	hydrogen sulfide biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue PG4 A 301

Chain	Residue
A	ALA75
A	ASP76
A	ASN103
A	ASN105
A	HOH410
B	PEG301

---

site_id	AC2
Number of Residues	5
Details	binding site for residue PEG B 301

Chain	Residue
B	ASN103
B	ASN105
A	PG4301
B	ALA75
B	ASP76

---

site_id	AC3
Number of Residues	1
Details	binding site for residue P6G D 301

Chain	Residue
D	TRP210

---

Functional Information from PROSITE/UniProt

site_id	PS00867
Number of Residues	8
Details	CPSASE_2 Carbamoyl-phosphate synthase subdomain signature 2. LNELNVKT

Chain	Residue	Details
A	LEU149-THR156

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	ACT_SITE: Nucleophile; cysteine thiosulfonate intermediate => ECO:0000255|HAMAP-Rule:MF_00063

Chain	Residue	Details
A	CYS244
B	CYS244
C	CYS244
D	CYS244
E	CYS244
F	CYS244
G	CYS244
H	CYS244

---