6VPL

TPX2 residues 7-20 fused to Aurora A residues 116-389 with C290 disulfide bonded to compound 7-80, and in complex with AMP-PNP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000212	biological_process	meiotic spindle organization
A	0000226	biological_process	microtubule cytoskeleton organization
A	0000278	biological_process	mitotic cell cycle
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
A	0007052	biological_process	mitotic spindle organization
A	0007098	biological_process	centrosome cycle
A	0007100	biological_process	mitotic centrosome separation
A	0051321	biological_process	meiotic cell cycle
B	0000212	biological_process	meiotic spindle organization
B	0000226	biological_process	microtubule cytoskeleton organization
B	0000278	biological_process	mitotic cell cycle
B	0004672	molecular_function	protein kinase activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation
B	0007052	biological_process	mitotic spindle organization
B	0007098	biological_process	centrosome cycle
B	0007100	biological_process	mitotic centrosome separation
B	0051321	biological_process	meiotic cell cycle

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue MG A 601

Chain	Residue
A	ASP11
B	SER7
B	GLU175
B	HIS176
B	ARG179

---

site_id	AC2
Number of Residues	16
Details	binding site for residue ANP A 602

Chain	Residue
A	ALA160
A	LYS162
A	LEU194
A	GLU211
A	TYR212
A	ALA213
A	THR217
A	ASP274
A	MG604
A	HOH734
A	HOH842
B	TPO288
A	LEU139
A	GLY140
A	GLY142
A	LYS143

---

site_id	AC3
Number of Residues	4
Details	binding site for residue MLA A 603

Chain	Residue
A	ARG304
A	HIS366
A	ASN367
A	HOH805

---

site_id	AC4
Number of Residues	3
Details	binding site for residue MG A 604

Chain	Residue
A	LYS162
A	GLU181
A	ANP602

---

site_id	AC5
Number of Residues	5
Details	binding site for residue MG A 605

Chain	Residue
A	SER7
A	GLU175
A	HIS176
A	ARG179
B	ASP11

---

site_id	AC6
Number of Residues	12
Details	binding site for residue R7D A 606

Chain	Residue
A	SER116
A	LEU289
A	CYS290
A	MET300
A	ILE301
A	HIS306
A	HOH720
A	HOH793
B	ARG255
B	TRP277
B	MET305
B	TYR338

---

site_id	AC7
Number of Residues	14
Details	binding site for residue ANP B 601

Chain	Residue
B	GLY142
B	LYS143
B	PHE144
B	VAL147
B	ALA160
B	LYS162
B	LEU194
B	GLU211
B	ALA213
B	MG604
B	HOH703
B	HOH704
B	HOH867
B	HOH881

---

site_id	AC8
Number of Residues	6
Details	binding site for residue GOL B 602

Chain	Residue
A	TYR334
B	GLY291
B	THR292
B	LEU293
B	ASP294
B	HOH707

---

site_id	AC9
Number of Residues	5
Details	binding site for residue MLA B 603

Chain	Residue
A	LYS224
B	ARG304
B	HIS366
B	ASN367
B	HOH789

---

site_id	AD1
Number of Residues	3
Details	binding site for residue MG B 604

Chain	Residue
B	LYS162
B	GLU181
B	ANP601

---

site_id	AD2
Number of Residues	12
Details	binding site for residue R7D B 605

Chain	Residue
A	TRP277
A	MET305
A	TYR338
B	LEU289
B	CYS290
B	LEU293
B	MET300
B	ILE301
B	HIS306
B	HOH713
B	HOH802
B	HOH837

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGKGKFGNVYlArekqskfi..........LALK

Chain	Residue	Details
A	LEU139-LYS162

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ViHrDIKpeNLLL

Chain	Residue	Details
A	VAL252-LEU264

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"14580337","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27837025","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5G1X","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"14580337","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19668197","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"11039908","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"13678582","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14580337","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16246726","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18662907","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19668197","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26246606","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by PKA and PAK","evidences":[{"source":"PubMed","id":"16246726","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---