Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| B | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue NA A 501 |
| Chain | Residue |
| A | ASP60 |
| A | HOH622 |
| A | HOH646 |
| A | HOH651 |
| A | HOH662 |
| A | HOH684 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue CL A 502 |
| Chain | Residue |
| B | ARG41 |
| A | THR74 |
| A | ASN88 |
| A | HOH692 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | binding site for residue GOL A 503 |
| Chain | Residue |
| A | GLN18 |
| A | MET36 |
| A | SER37 |
| A | HOH609 |
| A | HOH711 |
| B | THR12 |
| B | GLU65 |
| B | ALA67 |
| B | GLY68 |
| B | HOH380 |
| site_id | AC4 |
| Number of Residues | 30 |
| Details | binding site for residue T1R B 201 |
| Chain | Residue |
| A | LEU23 |
| A | ASP25 |
| A | GLY27 |
| A | ALA28 |
| A | ASP29 |
| A | ASP30 |
| A | ILE47 |
| A | GLY48 |
| A | GLY49 |
| A | ILE50 |
| A | PRO81 |
| A | VAL82 |
| A | ILE84 |
| A | HOH643 |
| A | HOH647 |
| B | ASP25 |
| B | GLY27 |
| B | ALA28 |
| B | ASP29 |
| B | ASP30 |
| B | ILE47 |
| B | GLY48 |
| B | GLY49 |
| B | ILE50 |
| B | VAL82 |
| B | ILE84 |
| B | HOH320 |
| B | HOH325 |
| B | HOH340 |
| B | HOH349 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | binding site for residue CL B 202 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue FMT B 203 |
| Chain | Residue |
| B | SER37 |
| B | TYR59 |
| B | HOH314 |
Functional Information from PROSITE/UniProt
| site_id | PS00141 |
| Number of Residues | 12 |
| Details | ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGADDTVI |
| Chain | Residue | Details |
| A | ALA22-ILE33 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | Region: {"description":"Dimerization of protease","evidences":[{"source":"UniProtKB","id":"P04585","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"description":"For protease activity; shared with dimeric partner","evidences":[{"source":"PROSITE-ProRule","id":"PRU10094","evidenceCode":"ECO:0000255"}]} |
