6VO6
Crystal Structure of Cj1427, an Essential NAD-dependent Dehydrogenase from Campylobacter jejuni, in the Presence of NADH and GDP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0019003 | molecular_function | GDP binding |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0045227 | biological_process | capsule polysaccharide biosynthetic process |
| A | 0051289 | biological_process | protein homotetramerization |
| A | 0070404 | molecular_function | NADH binding |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0019003 | molecular_function | GDP binding |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0045227 | biological_process | capsule polysaccharide biosynthetic process |
| B | 0051289 | biological_process | protein homotetramerization |
| B | 0070404 | molecular_function | NADH binding |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0019003 | molecular_function | GDP binding |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0045227 | biological_process | capsule polysaccharide biosynthetic process |
| C | 0051289 | biological_process | protein homotetramerization |
| C | 0070404 | molecular_function | NADH binding |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0019003 | molecular_function | GDP binding |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0045227 | biological_process | capsule polysaccharide biosynthetic process |
| D | 0051289 | biological_process | protein homotetramerization |
| D | 0070404 | molecular_function | NADH binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 32 |
| Details | binding site for residue NAI A 401 |
| Chain | Residue |
| A | GLY9 |
| A | GLY56 |
| A | ASP57 |
| A | ALA58 |
| A | LEU77 |
| A | ALA78 |
| A | ALA79 |
| A | VAL81 |
| A | ILE96 |
| A | PRO117 |
| A | ASN118 |
| A | ALA11 |
| A | TYR144 |
| A | LYS148 |
| A | LEU166 |
| A | VAL169 |
| A | ARG175 |
| A | ARG177 |
| A | LEU180 |
| A | EDO403 |
| A | HOH533 |
| A | HOH548 |
| A | GLY12 |
| A | HOH595 |
| A | HOH615 |
| C | ASN311 |
| A | TYR13 |
| A | ILE14 |
| A | ASP33 |
| A | ASN34 |
| A | MET36 |
| A | GLN39 |
| site_id | AC2 |
| Number of Residues | 25 |
| Details | binding site for residue GDP A 402 |
| Chain | Residue |
| A | GLY82 |
| A | PRO84 |
| A | THR168 |
| A | ASP179 |
| A | LEU180 |
| A | LEU181 |
| A | ASP184 |
| A | PHE185 |
| A | VAL196 |
| A | LEU197 |
| A | PHE198 |
| A | ARG204 |
| A | LYS242 |
| A | ARG270 |
| A | HOH533 |
| A | HOH535 |
| A | HOH543 |
| A | HOH560 |
| A | HOH561 |
| A | HOH600 |
| A | HOH673 |
| A | HOH678 |
| A | HOH687 |
| A | HOH708 |
| C | PHE194 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | binding site for residue EDO A 403 |
| Chain | Residue |
| A | THR119 |
| A | ASN120 |
| A | SER121 |
| A | LEU166 |
| A | ALA167 |
| A | THR168 |
| A | ARG270 |
| A | TYR272 |
| A | NAI401 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 404 |
| Chain | Residue |
| A | THR52 |
| A | GLU67 |
| A | LYS70 |
| A | EDO405 |
| A | HOH503 |
| A | HOH627 |
| A | HOH652 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | binding site for residue EDO A 405 |
| Chain | Residue |
| A | LYS4 |
| A | VAL5 |
| A | GLU28 |
| A | CYS30 |
| A | LYS70 |
| A | EDO404 |
| A | HOH532 |
| A | HOH544 |
| A | HOH627 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 406 |
| Chain | Residue |
| A | ASN62 |
| A | ARG65 |
| A | HOH504 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 407 |
| Chain | Residue |
| A | SER237 |
| A | THR289 |
| A | LEU290 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue TMA A 408 |
| Chain | Residue |
| A | ALA69 |
| A | LYS70 |
| A | ALA71 |
| A | ASP72 |
| A | HOH731 |
| site_id | AC9 |
| Number of Residues | 34 |
| Details | binding site for residue NAI B 401 |
| Chain | Residue |
| B | ASN34 |
| B | MET36 |
| B | PHE37 |
| B | GLN39 |
| B | GLY56 |
| B | ASP57 |
| B | ALA58 |
| B | LEU77 |
| B | ALA78 |
| B | ALA79 |
| B | VAL81 |
| B | ILE96 |
| B | PRO117 |
| B | ASN118 |
| B | TYR144 |
| B | LYS148 |
| B | LEU166 |
| B | VAL169 |
| B | ARG175 |
| B | ARG177 |
| B | LEU180 |
| B | EDO403 |
| B | HOH540 |
| B | HOH583 |
| B | HOH616 |
| B | HOH622 |
| B | HOH670 |
| D | ASN311 |
| B | GLY9 |
| B | ALA11 |
| B | GLY12 |
| B | TYR13 |
| B | ILE14 |
| B | ASP33 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 402 |
| Chain | Residue |
| B | LEU23 |
| B | ASN48 |
| B | HOH518 |
| B | HOH610 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 403 |
| Chain | Residue |
| B | VAL81 |
| B | TYR144 |
| B | ARG177 |
| B | NAI401 |
| B | HOH540 |
| B | HOH558 |
| site_id | AD3 |
| Number of Residues | 8 |
| Details | binding site for residue EDO B 404 |
| Chain | Residue |
| A | GLU247 |
| A | LYS251 |
| A | HOH520 |
| B | PRO110 |
| B | SER111 |
| B | HOH506 |
| B | HOH576 |
| B | HOH587 |
| site_id | AD4 |
| Number of Residues | 1 |
| Details | binding site for residue EDO B 405 |
| Chain | Residue |
| B | LYS242 |
| site_id | AD5 |
| Number of Residues | 3 |
| Details | binding site for residue TMA B 406 |
| Chain | Residue |
| B | ASP287 |
| B | ASN288 |
| B | ASP292 |
| site_id | AD6 |
| Number of Residues | 5 |
| Details | binding site for residue TMA B 407 |
| Chain | Residue |
| B | PHE198 |
| D | GLU135 |
| D | LYS193 |
| D | ASP255 |
| D | HOH804 |
| site_id | AD7 |
| Number of Residues | 34 |
| Details | binding site for residue NAI C 401 |
| Chain | Residue |
| A | ASN311 |
| C | GLY9 |
| C | ALA11 |
| C | GLY12 |
| C | TYR13 |
| C | ILE14 |
| C | ASP33 |
| C | ASN34 |
| C | MET36 |
| C | PHE37 |
| C | GLN39 |
| C | GLY56 |
| C | ASP57 |
| C | ALA58 |
| C | LEU77 |
| C | ALA78 |
| C | ALA79 |
| C | VAL81 |
| C | ILE96 |
| C | PRO117 |
| C | ASN118 |
| C | TYR144 |
| C | LYS148 |
| C | LEU166 |
| C | VAL169 |
| C | ARG175 |
| C | ARG177 |
| C | LEU180 |
| C | EDO403 |
| C | HOH530 |
| C | HOH570 |
| C | HOH581 |
| C | HOH609 |
| C | HOH678 |
| site_id | AD8 |
| Number of Residues | 6 |
| Details | binding site for residue EDO C 402 |
| Chain | Residue |
| C | THR52 |
| C | GLU67 |
| C | LYS70 |
| C | HOH520 |
| C | HOH555 |
| C | HOH569 |
| site_id | AD9 |
| Number of Residues | 6 |
| Details | binding site for residue EDO C 403 |
| Chain | Residue |
| C | VAL81 |
| C | TYR144 |
| C | ARG177 |
| C | NAI401 |
| C | HOH526 |
| C | HOH560 |
| site_id | AE1 |
| Number of Residues | 9 |
| Details | binding site for residue EDO C 404 |
| Chain | Residue |
| C | LYS4 |
| C | VAL5 |
| C | GLU28 |
| C | CYS30 |
| C | LYS70 |
| C | HOH502 |
| C | HOH555 |
| C | HOH557 |
| C | HOH613 |
| site_id | AE2 |
| Number of Residues | 4 |
| Details | binding site for residue TMA C 405 |
| Chain | Residue |
| C | ALA69 |
| C | LYS70 |
| C | ALA71 |
| C | ASP72 |
| site_id | AE3 |
| Number of Residues | 32 |
| Details | binding site for residue NAI D 401 |
| Chain | Residue |
| B | ASN311 |
| B | HOH551 |
| D | GLY9 |
| D | ALA11 |
| D | GLY12 |
| D | TYR13 |
| D | ILE14 |
| D | ASP33 |
| D | ASN34 |
| D | MET36 |
| D | GLN39 |
| D | GLY56 |
| D | ASP57 |
| D | ALA58 |
| D | LEU77 |
| D | ALA78 |
| D | ALA79 |
| D | VAL81 |
| D | ILE96 |
| D | PRO117 |
| D | ASN118 |
| D | TYR144 |
| D | LYS148 |
| D | LEU166 |
| D | VAL169 |
| D | ARG175 |
| D | ARG177 |
| D | LEU180 |
| D | EDO404 |
| D | HOH548 |
| D | HOH600 |
| D | HOH606 |
| site_id | AE4 |
| Number of Residues | 22 |
| Details | binding site for residue GDP D 402 |
| Chain | Residue |
| D | GLY82 |
| D | THR168 |
| D | ASP179 |
| D | LEU180 |
| D | LEU181 |
| D | ASP184 |
| D | PHE185 |
| D | VAL196 |
| D | LEU197 |
| D | PHE198 |
| D | ARG204 |
| D | LYS242 |
| D | ARG270 |
| D | HOH501 |
| D | HOH530 |
| D | HOH548 |
| D | HOH582 |
| D | HOH647 |
| D | HOH660 |
| D | HOH664 |
| D | HOH686 |
| D | HOH699 |
| site_id | AE5 |
| Number of Residues | 5 |
| Details | binding site for residue NA D 403 |
| Chain | Residue |
| D | GLY124 |
| D | GLU127 |
| D | ASP271 |
| D | HOH605 |
| D | HOH662 |
| site_id | AE6 |
| Number of Residues | 9 |
| Details | binding site for residue EDO D 404 |
| Chain | Residue |
| D | THR119 |
| D | ASN120 |
| D | SER121 |
| D | LEU166 |
| D | ALA167 |
| D | THR168 |
| D | ARG270 |
| D | TYR272 |
| D | NAI401 |
| site_id | AE7 |
| Number of Residues | 6 |
| Details | binding site for residue EDO D 405 |
| Chain | Residue |
| D | THR52 |
| D | GLU67 |
| D | LYS70 |
| D | HOH517 |
| D | HOH519 |
| D | HOH651 |
| site_id | AE8 |
| Number of Residues | 3 |
| Details | binding site for residue TMA D 406 |
| Chain | Residue |
| D | ASP287 |
| D | ASN288 |
| D | ASP292 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 115 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"32168450","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VO6","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
